Compile Data Set for Download or QSAR
Report error Found 30 of ic50 data for polymerid = 5272,50000796
TargetAcyl-protein thioesterase 2(Mouse)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50547464(CHEMBL4776695)
Affinity DataIC50: 12nMAssay Description:Inhibition of FP-Rh binding to APT-1/2 in mouse brain cytosolic fraction preincubated for 1 hr followed by FP-Rh addition and measured after 1 hr by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50496629(CHEMBL3133031)
Affinity DataIC50: 20nMAssay Description:Inhibition of APT2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Mouse)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50547465(CHEMBL4792406)
Affinity DataIC50: 28nMAssay Description:Inhibition of FP-Rh binding to APT-1/2 in mouse brain cytosolic fraction preincubated for 1 hr followed by FP-Rh addition and measured after 1 hr by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50496626(CHEMBL1903566)
Affinity DataIC50: 30nMAssay Description:Inhibition of human APT2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50336546(Palmostatin B | CHEMBL1673415)
Affinity DataIC50: 38nMAssay Description:Inhibition of APT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50282567(3,4-Dichlorophenyl boronic acid | Phenylboronic ac...)
Affinity DataIC50: 138nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50496625(CHEMBL3133033)
Affinity DataIC50: 200nMAssay Description:Inhibition of human APT2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92722(Phenylboronic acid, 15)
Affinity DataIC50: 238nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92718(Phenylboronic acid, 10)
Affinity DataIC50: 418nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM26139(Phenylboronic acid, 11 | 1-benzothiophen-2-ylboran...)
Affinity DataIC50: 529nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM207992(ML349)
Affinity DataIC50: 1.10E+3nM Kd:  240nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM207992(ML349)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of fluorescein-labeled ML349 binding to HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) after 30 mins by flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92719(Phenylboronic acid, 12)
Affinity DataIC50: 1.60E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92721(Phenylboronic acid, 14)
Affinity DataIC50: 1.80E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92717(Phenylboronic acid, 8)
Affinity DataIC50: 1.97E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92727(Phenylboronic acid, 20)
Affinity DataIC50: 1.98E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92726(Phenylboronic acid, 19)
Affinity DataIC50: 2.16E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92724(Phenylboronic acid, 17)
Affinity DataIC50: 2.87E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92723(Phenylboronic acid, 16)
Affinity DataIC50: 2.95E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataIC50: 3.55E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92720(Phenylboronic acid, 13)
Affinity DataIC50: 4.10E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92725(Phenylboronic acid, 18)
Affinity DataIC50: 4.18E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50212216(CHEMBL3944678)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of fluorescein-labeled ML349 binding to HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) after 30 mins by flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50211276(CHEMBL1891894)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human APT2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM26140(Phenylboronic acid, 21 | CHEMBL143399 | 1-benzofur...)
Affinity DataIC50: 1.13E+4nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM207994(ML349-sulfoxide)
Affinity DataIC50: 1.20E+4nM Kd:  5.20E+3nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM26996(Phenylboronic acid, 22 | benzeneboronic acid | CHE...)
Affinity DataIC50: 2.51E+4nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM92728(Phenylboronic acid, 7)
Affinity DataIC50: 4.15E+4nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM26137((2-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataIC50: 5.00E+4nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM207995(ML349-thioether)
Affinity DataIC50: 1.00E+5nM Kd: >1.00E+4nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed