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Report error Found 371 of ic50 data for polymerid = 5143
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373712(US10246444, Example 92)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of HER4 (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.100nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.100nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 0.100nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373723(US10246444, Example 90)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of HER4 (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human HER4 using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human HER4 using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of HER4 (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50182693(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50455738(CHEMBL4211949)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human ErbB4 using Poly(Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50182684(N-[4-[(3-bromo-4-fluorophenyl)amino]pyrido[3,4-d]p...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50182682(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 1nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50182688(N-[4-[(3-bromo-4-fluorophenyl)amino]pyrido[3,4-d]p...)
Affinity DataIC50: 1nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191486(CHEMBL3959248)
Affinity DataIC50: 1nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HER4 (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50182697(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM333465(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methy...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM333465(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methy...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50544053(CHEMBL4647228)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HER4 (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM333446(N-[4-(3-chloro-4- fluorophenylamino)-7-((8-methyl-...)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM333446(N-[4-(3-chloro-4- fluorophenylamino)-7-((8-methyl-...)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human HER4 using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human HER4 using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50604104(CHEMBL5182567)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50182695(N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-prop...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM333447(N-[4-(3-chloro-4- fluorophenylamino)-7-(8-methyl-1...)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM333447(N-[4-(3-chloro-4- fluorophenylamino)-7-(8-methyl-1...)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50182678(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human ErbB4 using Poly(Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM333466(N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-...)
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM333466(N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-...)
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191661(CHEMBL3890186)
Affinity DataIC50: 2nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191495(CHEMBL3896779)
Affinity DataIC50: 2nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50604105(CHEMBL5208454)
Affinity DataIC50: 2nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataIC50: 2.20nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50182687(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50240782(CHEMBL4075917)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant ErbB4 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ErbB4 (unknown origin) by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191586(CHEMBL3977504)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191479(CHEMBL3958482)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191654(CHEMBL3932176)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191589(CHEMBL3986103)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191641(CHEMBL3949347)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191655(CHEMBL3970330)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50191502(CHEMBL3981551)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50520589(CHEMBL4473365)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ErbB4 cytoplasmic domain expressed in baculovirus expression system by Z-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 3.20nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 3.20nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ERBB4 cytoplasmic domain (708 to 993 residues) expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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