Compile Data Set for Download or QSAR
Report error Found 37 of ic50 data for polymerid = 50006449
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469320(CHEMBL4293567 | US11958846, Example 5)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469331(CHEMBL4282980 | US11958846, Example 6)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469324(CHEMBL4286345 | US11958846, Example 4)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469330(CHEMBL4295096 | US11958846, Example 7)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469329(CHEMBL4278436 | US11958846, Example 1)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469325(CHEMBL4294655 | US11958846, Example 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469321(CHEMBL4286757 | US11958846, Example 2)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM394583(US10308614, Example 186 | 2-(6-amino-5-phenylpyrid...)
Affinity DataIC50: 30nMAssay Description:Inhibition of His-tagged SMARCA4 (unknown origin) (1448 to 1575 residues) using biotinylated ARTKQTARKSTGG-K(Ac)-APR-K(Ac)-QLAT-K(Ac)-AAR-K(Ac)-SAPGG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469333(CHEMBL4290175)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM394530(US10308614, Example 131 | (R)-1-(4-(3-amino-6-(2-)
Affinity DataIC50: 35nMAssay Description:Inhibition of His-tagged SMARCA4 (unknown origin) (1448 to 1575 residues) using biotinylated ARTKQTARKSTGG-K(Ac)-APR-K(Ac)-QLAT-K(Ac)-AAR-K(Ac)-SAPGG...More data for this Ligand-Target Pair
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM646012(US20240018158, Example 2b | (2S,4R)-4-hydroxy-N-[[...)
Affinity DataIC50: 100nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
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US Patent

TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM646010((2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxypheny...)
Affinity DataIC50: 100nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469322(CHEMBL4281368)
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50266286(CHEMBL4650213)
Affinity DataIC50: 263nMAssay Description:Alphascreen assay. Binding to SMARCA4A (domain start/stop: L1451-E1580) by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50266286(CHEMBL4650213)
Affinity DataIC50: 411nMAssay Description:Alphascreen assay. Binding to SMARCA4A (domain start/stop: L1451-E1580) by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM646012(US20240018158, Example 2b | (2S,4R)-4-hydroxy-N-[[...)
Affinity DataIC50: 550nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM394406(US10308614, Example 7 | 2-(6-amino-5-(piperazin-)
Affinity DataIC50: 550nMAssay Description:Inhibition of SMARCA4 BD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50481805(CHEMBL5278697)
Affinity DataIC50: 560nMAssay Description:Inhibition of SMARCA4 BD (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469327(CHEMBL4282784)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50266286(CHEMBL4650213)
Affinity DataIC50: 648nMAssay Description:Alphascreen assay. Binding to SMARCA4A (domain start/stop: L1451-E1580) by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469323(CHEMBL4290675)
Affinity DataIC50: 770nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM342597(N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50256397(CHEMBL4088466)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469328(CHEMBL4292870)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant His6-tagged BRG1 ATPase-SnAC (658 to 1361 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598934(CHEMBL5183240)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of His-tagged SMARCA4 (unknown origin) (1448 to 1575 residues) using biotinylated ARTKQTARKSTGG-K(Ac)-APR-K(Ac)-QLAT-K(Ac)-AAR-K(Ac)-SAPGG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50184973(CHEMBL3822828)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50184975(CHEMBL3823214)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50184974(CHEMBL3823057)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 9.00E+3nMAssay Description:Binding affinity to human partial length SMARCA4 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 9.00E+3nMAssay Description:Binding affinity to human partial length SMARCA4 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50184972(CHEMBL3823525)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50184971(CHEMBL3823210)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of His-tagged BRG1 (unknown origin) using biotinylated acetylated peptide as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 from BRG1 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to BRG1 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50184976(CHEMBL3823365)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598935(CHEMBL5194650)
Affinity DataIC50: 5.71E+4nMAssay Description:Inhibition of His-tagged SMARCA4 (unknown origin) (1448 to 1575 residues) using biotinylated ARTKQTARKSTGG-K(Ac)-APR-K(Ac)-QLAT-K(Ac)-AAR-K(Ac)-SAPGG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed