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TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591075(CHEMBL5200118)
Affinity DataIC50: 2nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614973(US20230271939, Example 11)
Affinity DataIC50: 2.30nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614966(US20230271939, Example 4)
Affinity DataIC50: 2.90nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591046(CHEMBL5202342)
Affinity DataIC50: 3nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614965(US20230271939, Example 3 | US20230271939, Compound...)
Affinity DataIC50: 3.5nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614965(US20230271939, Example 3 | US20230271939, Compound...)
Affinity DataIC50: 3.5nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50623413(CHEMBL5427321)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant GCN2 using eIF2alpha as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614995(US20230271939, Example 33)
Affinity DataIC50: 4.20nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50072072(CHEMBL3407849)
Affinity DataIC50: 5nMAssay Description:Inhibition of human C-terminal His-tagged GCN2 expressed in Escherichia coli using AviTag C-terminal, N-terminal His-tagged eIF2alpha (3 to 315) as s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591045(CHEMBL5209076)
Affinity DataIC50: 5nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591054(CHEMBL5179922)
Affinity DataIC50: 5nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50: 5nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM615005(US20230271939, Comp Ex 4 | WO2018030466, Example 5)
Affinity DataIC50: 5.80nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM615001(US20230271939, Comp Ex 1)
Affinity DataIC50: 5.90nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614968(US20230271939, Example 6)
Affinity DataIC50: 6.70nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataIC50: 7.20nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataIC50: 7.20nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614971(US20230271939, Example 9)
Affinity DataIC50: 7.5nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614967(US20230271939, Example 5)
Affinity DataIC50: 7.80nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614969(US20230271939, Example 7)
Affinity DataIC50: 7.90nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591070(CHEMBL5208600)
Affinity DataIC50: 8nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591079(CHEMBL5196751)
Affinity DataIC50: 8nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614964(US20230271939, Example 2)
Affinity DataIC50: 8.10nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591075(CHEMBL5200118)
Affinity DataIC50: 9nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM614970(US20230271939, Example 8)
Affinity DataIC50: 9.90nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50072026(CHEMBL3407851)
Affinity DataIC50: 10nMAssay Description:Inhibition of human C-terminal His-tagged GCN2 expressed in Escherichia coli using AviTag C-terminal, N-terminal His-tagged eIF2alpha (3 to 315) as s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464791(US10793563, Compound I-122)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464794(US10793563, Compound I-124)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464784(US10793563, Compound I-120 | US10793563, Compound ...)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464797(US10793563, Compound I-126)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464781(US10793563, Compound I-117 | US10793563, Compound ...)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464806(US10793563, Compound I-135)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464807(US10793563, Compound I-136)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464778(US10793563, Compound I-114 | US10793563, Compound ...)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464818(US10793563, Compound I-148)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464787(US10793563, Compound I-149)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464822(US10793563, Compound I-153)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464786(US10793563, Compound I-154)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464828(US10793563, Compound I-160)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464844(US10793563, Compound I-175)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464845(US10793563, Compound I-176)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464848(US10793563, Compound I-179)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464849(US10793563, Compound I-180)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464855(US10793563, Compound I-186)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464862(US10793563, Compound I-193)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464864(US10793563, Compound I-196)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464866(US10793563, Compound I-198)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464867(US10793563, Compound I-199)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464868(US10793563, Compound I-200)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM464788(US10793563, Compound I-202)
Affinity DataIC50: 10nMAssay Description:An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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