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TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.133nMAssay Description:Inhibition of human MARK2 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.148nMAssay Description:Inhibition of human MARK2 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247036((1R,3aR, 6S,7R,7aS)- 5,5-difluoro- 7-((E)-2-(5- (3...)
Affinity DataIC50: 1.37nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 2nMAssay Description:Inhibition of MARK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247038(2-((1R,3aR, 6S,7R,7aS)-5,5- difluoro-7- ((E)-2-(5-...)
Affinity DataIC50: 2.62nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247035((1R,3aR,6S,7R, 7aS)-5,5-difluoro- 7-((E)-2-(5- (2-...)
Affinity DataIC50: 3.80nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 4nMAssay Description:Inhibition of PAR1B-a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 4.07nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247047((S and R)-2- ((1R,3aR,6S, 7R,7aS)-7- ((E)-2-(5-(2-...)
Affinity DataIC50: 4.41nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 4.43nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247044(3-((1R,3aR,6S, 7R,7aS)-7 -((E)- 2- (2'-cyano-[...)
Affinity DataIC50: 6.34nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247037((1R,3aR,6S,7R, 7aS)-7-((E)-2-(5- (2-cyanophenyl)- ...)
Affinity DataIC50: 6.92nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247042(1R,3aR,6S, 7R,7aS)-7-((E)-2- (2'-cyano-[3,3...)
Affinity DataIC50: 9.68nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 11.3nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247043(1-((1R,3aS,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(5-...)
Affinity DataIC50: 13.9nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247046(2-((1R,3aR,6S, 7R,7aS)-7-((E)- 2- (2'-cyano-[3...)
Affinity DataIC50: 21.2nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataIC50: 52nMAssay Description:Inhibition of MARK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM247045(2-((1R,3aR,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(2&...)
Affinity DataIC50: 104nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAR-1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50204693(3-(4'-hydroxy-biphenyl-4-yl)-1,4-dihydro-indeno[1,...)
Affinity DataIC50: 4.59E+3nMAssay Description:Inhibition of EMK by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50218709(2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant EMK by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MARK2 using [KKKVSRSGLYRSPSMPENLNRPR] as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MARK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant full-length human PAR1Balpha using KKKVSRSGLYRSP as substrate measured after 40 mins in presence of [gamma33P]ATP by radiom...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50218700(2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydr...)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of recombinant EMK by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MARK2/PAR-1BalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of MARK2/PAR-1BalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EMK by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MARK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full length human GST-tagged MARK2 expressed in baculovirus expression system using serine/threonine-21 peptide as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed