Compile Data Set for Download or QSAR
Report error Found 483 of ic50 data for polymerid = 50001795,50006440
LigandPNGBDBM354724(US9814704, Example 1 | BDBM356235)
Affinity DataIC50: 3nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human MLK3 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human N-terminal HA-tagged wild type MLK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal HA-tagged recombinant wild-type human MLK3 overexpressed in HEK293A cells preincubated for 10 mins followed by [gamma-32P]AT...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human MLK3 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM24942(methyl (15S,16R,18R)-10,23-bis[(ethylsulfanyl)meth...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50620990(CHEMBL5403058)
Affinity DataIC50: 6nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50620994(CHEMBL5397520)
Affinity DataIC50: 6nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50441571(CHEMBL2436982 | US9814704, Example 18 | US10485800...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50458548(CHEMBL4218417)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant GST-tagged full length human MLK3 KD expressed in baculovirus using myelin basic protein as substrate preincubated for 15 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50620999(CHEMBL5417152)
Affinity DataIC50: 8nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
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PubMed
LigandPNGBDBM50441570(CHEMBL2436976 | US9814704, Example 17 | US10485800...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50108293(Indolocarbazole analogue | CHEMBL277817)
Affinity DataIC50: 11nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50108296(Indolocarbazole analogue | CHEMBL289772)
Affinity DataIC50: 11nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50108295(Indolocarbazole analogue | CHEMBL288817)
Affinity DataIC50: 11nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50621000(CHEMBL5436267)
Affinity DataIC50: 11nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
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PubMed
LigandPNGBDBM14186(3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,...)
Affinity DataIC50: 12nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 13nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50: 14nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50621002(CHEMBL5409050)
Affinity DataIC50: 14nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
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PubMed
LigandPNGBDBM50621004(CHEMBL5416972)
Affinity DataIC50: 14nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
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PubMed
LigandPNGBDBM50621003(CHEMBL5435826)
Affinity DataIC50: 17nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
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PubMed
LigandPNGBDBM50441569(CHEMBL2436981 | US9814704, Example 4 | US10485800,...)
Affinity DataIC50: 19nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50058332(methyl 10,23-di(ethylsulfanylmethyl)-16-hydroxy-15...)
Affinity DataIC50: 20nMAssay Description:Inhibition of flag-tagged MLK3 (unknown origin) expressed in human HeLa cells assessed as reduction in enzyme autophosphorylation incubated for 20 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50620995(CHEMBL5397819)
Affinity DataIC50: 20nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
LigandPNGBDBM50108299(Indolocarbazole analogue | CHEMBL288229)
Affinity DataIC50: 21nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50441566(CHEMBL2436977 | US10485800, Example 179)
Affinity DataIC50: 21nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14174(3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,...)
Affinity DataIC50: 22nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24942(methyl (15S,16R,18R)-10,23-bis[(ethylsulfanyl)meth...)
Affinity DataIC50: 23nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM24942(methyl (15S,16R,18R)-10,23-bis[(ethylsulfanyl)meth...)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant GST-tagged full length human MLK3 KD expressed in baculovirus using myelin basic protein as substrate preincubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM24942(methyl (15S,16R,18R)-10,23-bis[(ethylsulfanyl)meth...)
Affinity DataIC50: 23nMAssay Description:Inhibition of N-terminal GST-tagged recombinant MLK3 (unknown origin) expressed in insect cells incubated for 15 mins in presence of [gamma-32P]ATP b...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50620705(CHEMBL5413518)
Affinity DataIC50: 24nMAssay Description:Inhibition of MLK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50620705(CHEMBL5413518)
Affinity DataIC50: 24nMAssay Description:Inhibition of MLK3 (unknown origin) by cell-free radiolabeled ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50620996(CHEMBL5421283)
Affinity DataIC50: 25nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
LigandPNGBDBM14179(3-thia-13,23-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9...)
Affinity DataIC50: 26nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50620997(CHEMBL5436833)
Affinity DataIC50: 26nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
LigandPNGBDBM50621001(CHEMBL5440213)
Affinity DataIC50: 27nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
LigandPNGBDBM50108297(Indolocarbazole analogue | CHEMBL288816)
Affinity DataIC50: 31nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 39nMAssay Description:Inhibition of MLK3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14177(CHEMBL357490 | 3,13-diazahexacyclo[14.7.0.0^{2,10}...)
Affinity DataIC50: 40nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50441573(CHEMBL2436979 | US9814704, Example 40 | US10485800...)
Affinity DataIC50: 40nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50108291(Indolocarbazole analogue | CHEMBL36891)
Affinity DataIC50: 44nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM2581(CHEMBL16958 | 3,13,23-triazahexacyclo[14.7.0.0^{2,...)
Affinity DataIC50: 49nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50: 52nMAssay Description:Inhibition of human MLK3 using myelin basic protein as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM24947(3-(2-hydroxyethyl)-20-methoxy-3,13-diazahexacyclo[...)
Affinity DataIC50: 55nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50108292(Indolocarbazole analogue | CHEMBL37529)
Affinity DataIC50: 56nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50620993(CHEMBL5410283)
Affinity DataIC50: 57nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
LigandPNGBDBM14188(3-thia-13,23-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9...)
Affinity DataIC50: 58nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50620998(CHEMBL5407648)
Affinity DataIC50: 63nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
LigandPNGBDBM24942(methyl (15S,16R,18R)-10,23-bis[(ethylsulfanyl)meth...)
Affinity DataIC50: 64nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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