Compile Data Set for Download or QSAR
Report error Found 764 of ic50 data for polymerid = 50001130,50007454
TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700823(US20240342186, Example 2.04)
Affinity DataIC50: 1nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685849(US12043625, Example 1.03)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685857(US12043625, Example 1.11)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685874(US12043625, Example 2.03)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685878(US12043625, Example 2.07)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685882(US12043625, Example 2.11)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685892(US12043625, Example 3.01)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685893(US12043625, Example 3.02)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700793(US20240342186, Example 1.09)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700795(US20240342186, Example 1.11)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700804(US20240342186, Example 1.20)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700824(US20240342186, Example 2.05)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688363(US20240189315, Example 11)
Affinity DataIC50: 2.80nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685848(US12043625, Example 1.02)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685863(US12043625, Example 1.17)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685866(US12043625, Example 1.20)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685872(US12043625, Example 2.01)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685881(US12043625, Example 2.10)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688391(US20240189315, Example 37)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688392(US20240189315, Example 38)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688404(US20240189315, Ex. 1.12 of PCT/EP2022/062480))
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688404(US20240189315, Ex. 1.12 of PCT/EP2022/062480))
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700798(US20240342186, Example 1.14)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700800(US20240342186, Example 1.16)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700812(US20240342186, Example 1.28)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700814(US20240342186, Example 1.30)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700815(US20240342186, Example 1.31)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700817(US20240342186, Example 1.33)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700818(US20240342186, Example 1.34)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700822(US20240342186, Example 2.03)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700826(US20240342186, Example 2.07)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700827(US20240342186, Example 2.08)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700829(US20240342186, Example 2.10)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700847(US20240342186, Example 3.18)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM700849(US20240342186, Example 3.20)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688404(US20240189315, Ex. 1.12 of PCT/EP2022/062480))
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM639724(US20230391786, Example 193 | 3-[[6,7-Dichloro-3-(1...)
Affinity DataIC50: 3.22nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM639875((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...)
Affinity DataIC50: 3.38nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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