Compile Data Set for Download or QSAR
Report error Found 53 of ic50 data for polymerid = 50000682
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50214542((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331787((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331776((S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-(...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331786((S)-N-((S)-1-cyano-2-(pyridin-4-yl)ethyl)-4-fluoro...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331767(1-(4'-((S)-1-((S)-1-((S)-1-cyano-2-(4-cyano-2-fluo...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331771((S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methy...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331769((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331774((S)-2-((S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2,2,2-tri...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331770(1-(4'-((S)-1-((S)-1-((S)-1-cyano-2-phenylethylamin...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331773((S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methy...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331768((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 56nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331772((S)-N-((S)-1-cyano-2-phenylethyl)-2-((S)-1-(4'-((R...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331781((S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methy...)
Affinity DataIC50: 67nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM419133(GC376 | BDBM429386)
Affinity DataIC50: 74nMAssay Description:Inhibition of human Cathepsin F using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331788((S)-N-((R)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 76nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331779((S)-N-((S)-1-cyano-2-phenylethyl)-2-cyclopropyl-2-...)
Affinity DataIC50: 80nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331775((S)-N-((S)-1-cyano-2-phenylethyl)-3-cyclopropyl-2-...)
Affinity DataIC50: 147nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331778((S)-N-((S)-1-cyano-2-phenylethyl)-3-methyl-2-((S)-...)
Affinity DataIC50: 174nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50201701(cis-4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3....)
Affinity DataIC50: 331nMAssay Description:Inhibition of human recombinant cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50201700((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-...)
Affinity DataIC50: 487nMAssay Description:Inhibition of human recombinant cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM397464(US9988375, Compound 43 | US10676470, Compound 43 |...)
Affinity DataIC50: 500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM397464(US9988375, Compound 43 | US10676470, Compound 43 |...)
Affinity DataIC50: 500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331782((S)-N-(cyanomethyl)-4-fluoro-4-methyl-2-((S)-2,2,2...)
Affinity DataIC50: 547nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331783((S)-N-((S)-1-cyano-3,3,3-trifluoropropyl)-4-fluoro...)
Affinity DataIC50: 654nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331777((S)-N-((S)-1-cyano-2-phenylethyl)-3-phenyl-2-((S)-...)
Affinity DataIC50: 769nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 795nMAssay Description:Inhibition of cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM12311(SCH 503034 | (1R,5S)-N-[3-Amino-1-(cyclobutylmethy...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human Cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50201699((1R,2S)-2-isobutoxy-7-oxa-5-aza-bicyclo[3.2.1]octa...)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human recombinant cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331784((S)-N-((S)-1-cyano-3-phenylpropyl)-4-fluoro-4-meth...)
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50201705((1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 3.76E+3nMAssay Description:Inhibition of human recombinant cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50201698(rac-trans4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyc...)
Affinity DataIC50: 5.91E+3nMAssay Description:Inhibition of human recombinant cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 6.10E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 6.10E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453329(BDBM553832 | US10730826, Compound 47a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331780((S)-N-((S)-1-cyano-2-phenylethyl)-3,3-dimethyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453330(US10730826, Compound 50a | BDBM553833)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453332(BDBM553835 | US10730826, Compound 69a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453318(US10730826, Compound 18a | BDBM553824)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453329(BDBM553832 | US10730826, Compound 47a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453330(US10730826, Compound 50a | BDBM553833)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453318(US10730826, Compound 18a | BDBM553824)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331785((S)-N-((S)-cyano(1-phenylcyclopropyl)methyl)-4-flu...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326056((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM453332(BDBM553835 | US10730826, Compound 69a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50201702((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50201703((1S,2S)-2-bromo-7-oxa-5-aza-bicyclo[3.2.1]octan-6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50602407(CHEMBL5206532)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human cathepsin F using Z-Phe-Arg-AMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin F using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCathepsin F(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50589770(CHEMBL5188502)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin F using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
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