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TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668206(US20240124450, Example 45)
Affinity DataIC50: 0.400nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621264(CHEMBL5417444)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human SIK3 isoform 1 (59 to 1321 residues) expressed in Sf9 insect cells using AMARA peptide as substrate incubated for 120 mins in pre...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621264(CHEMBL5417444)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621284(CHEMBL5440720)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668167(US20240124450, Example 18 | US20240124450, Example...)
Affinity DataIC50: 0.700nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668195(US20240124450, Example 34 | US20240124450, Example...)
Affinity DataIC50: 0.700nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668202(US20240124450, Example 41)
Affinity DataIC50: 0.700nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668147(US20240124450, Example 6A | US20240124450, Example...)
Affinity DataIC50: 0.800nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668211(US20240124450, Example 50)
Affinity DataIC50: 0.800nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668197(US20240124450, Example 36 | US20240124450, Example...)
Affinity DataIC50: 0.900nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668208(US20240124450, Example 47)
Affinity DataIC50: 0.900nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.972nMAssay Description:Inhibition of human SIK3 using AMARAASAAALARRR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50622900(CHEMBL5438171)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SIK3 isoform 1 (59 to 1321 residues) expressed in Sf9 insect cells using AMARA peptide as substrate incubated for 120 mins in pre...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SIK3 isoform 1 (59 to 1321 residues) expressed in Sf9 insect cells using AMARA peptide as substrate incubated for 120 mins in pre...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668151(US20240124450, Example 9 | US20240124450, Example ...)
Affinity DataIC50: 1nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668167(US20240124450, Example 18 | US20240124450, Example...)
Affinity DataIC50: 1nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668167(US20240124450, Example 18 | US20240124450, Example...)
Affinity DataIC50: 1nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50622915(CHEMBL5415380)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human SIK3 isoform 1 (59 to 1321 residues) expressed in Sf9 insect cells using AMARA peptide as substrate incubated for 120 mins in pre...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 1.10nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668200(US20240124450, Example 39)
Affinity DataIC50: 1.10nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668204(US20240124450, Example 43)
Affinity DataIC50: 1.10nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM647308(US20240025892, Example 15)
Affinity DataIC50: 1.12nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 1.18nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human SIK3 using AMARAASAAALARRR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Nano-Luc fused full length recombinant SIK3 (unknown origin) transfected in HEK293 cells using AMARAASAAALARRR as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of SIK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 1.20nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668164(US20240124450, Example 16 | US20240124450, Example...)
Affinity DataIC50: 1.20nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50622906(CHEMBL5412961)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human SIK3 isoform 1 (59 to 1321 residues) expressed in Sf9 insect cells using AMARA peptide as substrate incubated for 120 mins in pre...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668154(US20240124450, Example 11A | US20240124450, Exampl...)
Affinity DataIC50: 1.30nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621266(CHEMBL5404502)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human SIK3 isoform 1 (59 to 1321 residues) expressed in Sf9 insect cells using AMARA peptide as substrate incubated for 120 mins in pre...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621266(CHEMBL5404502)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621274(CHEMBL5402124)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM647342(4-(7-(1- cyclopropyl- 1H-pyrazol-4- yl)imidazo[1,2...)
Affinity DataIC50: 1.43nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668189(US20240124450, Example 32A | US20240124450, Exampl...)
Affinity DataIC50: 1.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668214(US20240124450, Example 53)
Affinity DataIC50: 1.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668154(US20240124450, Example 11A | US20240124450, Exampl...)
Affinity DataIC50: 1.60nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668201(US20240124450, Example 40)
Affinity DataIC50: 1.60nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668212(US20240124450, Example 51)
Affinity DataIC50: 1.60nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM647345(US20240025892, Example 52)
Affinity DataIC50: 1.64nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM647353(2-cyclopropyl-5- (2,6-dimethoxy- 4-(7-(1-methyl- 1...)
Affinity DataIC50: 1.64nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621271(CHEMBL5439455)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621276(CHEMBL5405883)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621283(CHEMBL5437300)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668164(US20240124450, Example 16 | US20240124450, Example...)
Affinity DataIC50: 1.70nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668209(US20240124450, Example 48)
Affinity DataIC50: 1.70nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668147(US20240124450, Example 6A | US20240124450, Example...)
Affinity DataIC50: 1.80nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668195(US20240124450, Example 34 | US20240124450, Example...)
Affinity DataIC50: 1.80nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668199(US20240124450, Example 38)
Affinity DataIC50: 1.80nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM50621275(CHEMBL5410472)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
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