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TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468173(CHEMBL4284995)
Affinity DataIC50: 0.0750nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468167(CHEMBL4280968)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468163(CHEMBL4286872)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468164(CHEMBL4288368)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAA...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468174(CHEMBL4277729)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GCP-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant NAALADaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50358646(CHEMBL1921899)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of PSMA using N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid as substrate after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468175(CHEMBL4291782)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50358645(CHEMBL1921898)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of PSMA using N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid as substrate after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468177(CHEMBL4291245)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085699(2-[(2,4-Dicarboxy-butyl)-hydroxy-phosphinoylmethyl...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50331102(2-{[2-(4-Amino-4-carboxy-butyrylamino)-2-carboxyet...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of PSMA in human LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM578389(US11478558, Compound 1)
Affinity DataIC50: 0.570nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468178(CHEMBL4283406)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM578390(US11478558, Compound 2)
Affinity DataIC50: 0.640nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50503760(CHEMBL4442450)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222546(tetralithium (2S)-2-(phosphonatoamino)pentanedioat...)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of PSMAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468180(CHEMBL4294773)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468170(CHEMBL4292853)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468168(CHEMBL4291603)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468169(CHEMBL4281573)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM702999(US20240366809, Example 9)
Affinity DataIC50: 1.23nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468172(CHEMBL4289458)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM456920(US10736974, Entry 23)
Affinity DataIC50: 1.30nMAssay Description:The PSMA inhibitory activity was determined using a modification of the fluorescence-based Amplex Red Glutamic Acid Assay. Briefly, lysates of LNCaP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50544832(CHEMBL4636677)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]MIP-1095 from PSMA in human PC3-PIP cells after 1 hr by gamma counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106576(2-[(2-Carboxy-propyl)-hydroxy-phosphinoylmethyl]-p...)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50592344(CHEMBL5205430)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PSMA in human LNCaP cell extracts using NAAG as substrate by amplex red reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM702996(US20240366809, Compound v)
Affinity DataIC50: 1.52nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50514660(Dcfpyl | US10894807, ID P002)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAA...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM456914(US10736974, Entry 17 | US10736974, Compound XY-43)
Affinity DataIC50: 1.60nMAssay Description:The PSMA inhibitory activity was determined using a modification of the fluorescence-based Amplex Red Glutamic Acid Assay. Briefly, lysates of LNCaP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM702998(US20240366809, Compound PSMA-617)
Affinity DataIC50: 1.65nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50358647(CHEMBL1921900)
Affinity DataIC50: 1.93nMAssay Description:Inhibition of PSMA using N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid as substrate after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106577(2-[(2-Carboxy-3-phenyl-propyl)-hydroxy-phosphinoyl...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50265381((S)-2-(3-((S)-1-Carboxy-5-(4-chlorobenzylamino)pen...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50265453((S)-2-(3-((S)-1-Carboxy-5-(3-(4-bromophenyl)ureido...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50392040(CHEMBL2152556)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50392045(CHEMBL2152561)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM456921(US10736974, Entry 24)
Affinity DataIC50: 2nMAssay Description:The PSMA inhibitory activity was determined using a modification of the fluorescence-based Amplex Red Glutamic Acid Assay. Briefly, lysates of LNCaP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50544834(CHEMBL4636963)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1095 from PSMA in human PC3-PIP cells after 1 hr by gamma counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468171(CHEMBL4294649)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50592343(CHEMBL5202039)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PSMA in human LNCaP cell extracts using NAAG as substrate by amplex red reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM578391(US11478558, Compound 3)
Affinity DataIC50: 2.16nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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