Compile Data Set for Download or QSAR
Report error Found 962 of ic50 data for polymerid = 50000110,50002570,50003332
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50563999(CHEMBL4595698)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of [3H]NO711 binding to mouse GAT1 expressed in human HEK293 cell line by MS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526262(CHEMBL4439989)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50563999(CHEMBL4595698)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50563999(CHEMBL4595698)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of mouse GAT1 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080337((R)-1-{2-[2,2-Bis-(3-methyl-thiophen-2-yl)-vinylox...)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080337((R)-1-{2-[2,2-Bis-(3-methyl-thiophen-2-yl)-vinylox...)
Affinity DataIC50: 14nMAssay Description:Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526257(CHEMBL4555282)
Affinity DataIC50: 28nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526264(CHEMBL4452694)
Affinity DataIC50: 32nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 37nMAssay Description:Inhibition of [3H]NO711 binding to mouse GAT1 expressed in human HEK293 cell line by MS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50591808(CHEMBL5207397)
Affinity DataIC50: 37nMAssay Description:Inhibition of mouse GAT-1 assessed as inhibition of GABA uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50620847(CHEMBL5413261)
Affinity DataIC50: 37nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]-GABA uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526258(CHEMBL4455995)
Affinity DataIC50: 39nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)
Affinity DataIC50: 40nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)
Affinity DataIC50: 40nMAssay Description:Inhibition of GAT-1 in rat brain homogenate assessed as decrease in [3H]GABA uptake preincubated for 8 mins followed by [3H]GABA addition and measure...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50081889(1-[2-(3,3-Diphenyl-propoxy)-ethyl]-1,2,5,6-tetrahy...)
Affinity DataIC50: 48nMAssay Description:In vitro inhibition of [3H]GABA uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50368628(ABT-569 | Abbott-70569 | Abbott-70569.1 | Gabitril...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50591807(CHEMBL5178760)
Affinity DataIC50: 52nMAssay Description:Inhibition of mouse GAT-1 assessed as inhibition of GABA uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50081891(1-[2-(3,3-Diphenyl-propoxy)-ethyl]-piperidine-3-ca...)
Affinity DataIC50: 55nMAssay Description:In vitro inhibition of [3H]GABA uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426072(CHEMBL1190520)
Affinity DataIC50: 55nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526265(CHEMBL4520656)
Affinity DataIC50: 56nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50426072(CHEMBL1190520)
Affinity DataIC50: 60nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526261(CHEMBL4565664)
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50620846(CHEMBL5422397)
Affinity DataIC50: 62nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]-GABA uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 63.1nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526259(CHEMBL4565745)
Affinity DataIC50: 66nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50368628(ABT-569 | Abbott-70569 | Abbott-70569.1 | Gabitril...)
Affinity DataIC50: 67nMAssay Description:In vitro inhibition of [3H]GABA uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 70nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 70nMAssay Description:Inhibition of GAT-1 in rat brain homogenate assessed as decrease in [3H]GABA uptake preincubated for 8 mins followed by [3H]GABA addition and measure...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50081895((R)-1-[3-(3,3-Di-o-tolyl-allyloxy)-propyl]-piperid...)
Affinity DataIC50: 75nMAssay Description:In vitro inhibition of [3H]GABA uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080346((R)-1-(2-Benzhydrylideneaminooxy-ethyl)-piperidine...)
Affinity DataIC50: 80nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50368628(ABT-569 | Abbott-70569 | Abbott-70569.1 | Gabitril...)
Affinity DataIC50: 80nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426074(CHEMBL2315957)
Affinity DataIC50: 80nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50426074(CHEMBL2315957)
Affinity DataIC50: 80nMAssay Description:Inhibition of GAT-1 in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526263(CHEMBL4475547)
Affinity DataIC50: 85nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50081892((R)-1-[2-(3-Phenyl-3-o-tolyl-propoxy)-ethyl]-piper...)
Affinity DataIC50: 86nMAssay Description:In vitro inhibition of [3H]GABA uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50081888((R)-1-[2-(2-Diphenylamino-ethoxy)-ethyl]-piperidin...)
Affinity DataIC50: 90nMAssay Description:In vitro inhibition of [3H]GABA uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50281157(CHEMBL4167871)
Affinity DataIC50: 98nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426073(CHEMBL2315958)
Affinity DataIC50: 100nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50280945(CHEMBL4170661)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50491721(CHEMBL2387654)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50526260(CHEMBL4554639)
Affinity DataIC50: 102nMAssay Description:Inhibition of mouse GAT-1 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080379((R)-1-[2-(2,2-Diphenyl-vinyloxy)-ethyl]-piperidine...)
Affinity DataIC50: 104nMAssay Description:In vitro inhibition of [3H]GABA uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50081901((R)-1-[2-(3,3-Di-o-tolyl-allyloxy)-ethyl]-piperidi...)
Affinity DataIC50: 114nMAssay Description:In vitro inhibition of [3H]GABA uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50280956(CHEMBL4173921)
Affinity DataIC50: 126nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50020891((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
Affinity DataIC50: 130nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50: 130nMAssay Description:Compound was tested for its ability to inhibit uptake of [3H]- GABA by cloned human GAT-1 transporterMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50: 130nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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