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TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 4.5nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142255(US8933099, 21)
Affinity DataIC50: 5.10nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142236(US8933099, 2)
Affinity DataIC50: 6.40nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50000130(CHEMBL320550)
Affinity DataIC50: 25.2nMAssay Description:24% inhibition of FGF-2 binding to heparin-albumin by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167952(1-(4-(3-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Affinity DataIC50: 103nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 114nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167953(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Affinity DataIC50: 122nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167954(1-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)-3-...)
Affinity DataIC50: 145nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50000128(CHEMBL113091)
Affinity DataIC50: 149nMAssay Description:23% inhibition of FGF-2 binding to heparin-albumin by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167956(1-(4-(3,4-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Affinity DataIC50: 178nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167951(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Affinity DataIC50: 209nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167957(1-(4-(2,4-Dimethylphenyl)piperazin-1-yl)-3-(quinaz...)
Affinity DataIC50: 222nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167950(1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...)
Affinity DataIC50: 248nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167945(1-(4-Phenylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Affinity DataIC50: 293nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167949(1-(4-(4-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Affinity DataIC50: 300nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50421574(CHEMBL2303729)
Affinity DataIC50: 313nMAssay Description:23% inhibition of FGF-2 binding to heparin-albumin by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50421574(CHEMBL2303729)
Affinity DataIC50: 340nMAssay Description:25% inhibition of FGF-2 binding to heparin-albumin by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167948(1-(4-(2-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Affinity DataIC50: 372nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167955(1-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Affinity DataIC50: 398nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167947(1-(4-(3-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Affinity DataIC50: 402nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167959(1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Affinity DataIC50: 419nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167958(1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Affinity DataIC50: 444nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167946(1-(4-(2-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Affinity DataIC50: 506nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167960(1-(4-Ethylpiperazin-1-yl)-3-(quinazolin-4-yloxy)pr...)
Affinity DataIC50: 519nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167961(1-(Dimethylamino)-3-(quinazolin-4-yloxy)propan-2-o...)
Affinity DataIC50: 582nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167965(1-(2-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Affinity DataIC50: 586nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167966(1-(4-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Affinity DataIC50: 592nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167963(1-(Piperidin-1-yl)-3-(quinazolin-4-yloxy)propan-2-...)
Affinity DataIC50: 593nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167962(1-Morpholino-3-(quinazolin-4-yloxy)propan-2-ol (3r...)
Affinity DataIC50: 602nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM167964(1-(1H-Imidazol-1-yl)-3-(quinazolin-4-yloxy)propan-...)
Affinity DataIC50: 609nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50454865(CHEMBL4209610)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of fluorescein labelled heparin-like hexasaccharide probe binding to recombinant human FGF-2 after 5 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50182286(CHEMBL3819333)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50182285(CHEMBL3819473)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50260260(Biotin-Ala-(Arg)9 | [amino({[(1R,2S,3R,4R,5S)-5-{[...)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to biotinylated FGF2 in CHO cells by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50000129(CHEMBL112763)
Affinity DataIC50: 3.30E+4nMAssay Description:23% inhibition of FGF-2 binding to heparin-albumin by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50454864(CHEMBL4202957)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of fluorescein labelled heparin-like hexasaccharide probe binding to recombinant human FGF-2 after 5 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50454866(CHEMBL4213376)
Affinity DataIC50: 2.71E+5nMAssay Description:Inhibition of fluorescein labelled heparin-like hexasaccharide probe binding to recombinant human FGF-2 after 5 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed