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TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117772(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.00600nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of Lp-PLA2 in whole human plasma pre-incubated for 15 mins before 2-thio-PAF substrate additionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.0490nMAssay Description:Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.0490nMAssay Description:Inhibition of recombinant human Lp-PLA2 incubated for 20 mins by Thio-PAF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.0490nMAssay Description:Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117772(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.0631nMAssay Description:Inhibition of human recombinant LpPLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50093917(N-Decyl-4-[2-(4-fluoro-benzylsulfanyl)-4-oxo-5-pyr...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of lipoprotein associated phospholipase A2 in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117785(2-[2-(4-Fluoro-benzylsulfanyl)-5-(1-methyl-1H-pyra...)
Affinity DataIC50: 0.100nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125266(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Lp-PLA2 in human plasma LDL fractions using 2-thio platelet-activating factor as substrate by TMB dye based spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117788(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-{2-[ethyl-(2-h...)
Affinity DataIC50: 0.120nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117802(N-(2-Ethylamino-ethyl)-2-[2-(4-fluoro-benzylsulfan...)
Affinity DataIC50: 0.120nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50433667(CHEMBL2380965)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117778(2-[2-(4-Fluoro-benzylsulfanyl)-5-(1-methyl-1H-pyra...)
Affinity DataIC50: 0.170nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107480(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-b...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107505(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-b...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107512(2-[2-(4-Fluoro-benzylsulfanyl)-5-(2-methoxy-pyrimi...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117775(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-dimethylcarbam...)
Affinity DataIC50: 0.200nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117790(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-(2-diisopropyl...)
Affinity DataIC50: 0.200nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117791(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-(2-ethylamino-...)
Affinity DataIC50: 0.200nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117780(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-dimethylcarbam...)
Affinity DataIC50: 0.200nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117794(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-(2-dimethylami...)
Affinity DataIC50: 0.200nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107505(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-b...)
Affinity DataIC50: 0.200nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117801(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-b...)
Affinity DataIC50: 0.200nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50433665(CHEMBL2380967)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50433661(CHEMBL2380954)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125267(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-(2-diethylamin...)
Affinity DataIC50: 0.25nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of Lp-PLA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.25nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human Lp-PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50205805(Rilapladib | SB-659032)
Affinity DataIC50: 0.251nMAssay Description:Inhibition of LpPLA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50093916(N-Dodecyl-2-[2-(4-fluoro-benzylsulfanyl)-4-oxo-5-p...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of lipoprotein associated phospholipase A2 in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117773(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-b...)
Affinity DataIC50: 0.300nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117800(N-Dimethylcarbamoylmethyl-2-[2-(4-fluoro-benzylsul...)
Affinity DataIC50: 0.300nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117782(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-(3-diethylamin...)
Affinity DataIC50: 0.350nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50205804(CHEMBL3967156)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human recombinant LpPLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50093951(4-[2-(4-Fluoro-benzylsulfanyl)-4-oxo-5-pyrimidin-5...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of lipoprotein associated phospholipase A2 in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50093913(4-[2-(4-Fluoro-benzylsulfanyl)-4-oxo-5-pyrimidin-5...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against human lipoprotein associated phospholipase A2 (Lp-PLA2)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125268(N-(2-Diethylamino-ethyl)-2-[5-ethyl-2-(4-fluoro-be...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125272(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-(2-diethylamin...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50403796(CHEMBL2111560)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of lipoprotein associated phospholipase A2 in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50433658(CHEMBL2380957)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107481(N-(4'-Bromo-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-be...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107501(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[5-(1-ethyl-2-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107507(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-b...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117776(N-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethyl}-N-(4'-ch...)
Affinity DataIC50: 0.5nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117784(N-(4'-Chloro-biphenyl-4-ylmethyl)-N-(3-dimethylami...)
Affinity DataIC50: 0.5nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125270(N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulf...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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