Compile Data Set for Download or QSAR
Report error Found 243 of ic50 data for polymerid = 49001143,50002281
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50070103((E)-1-(2',5'-Dimethoxyphenyl)-3-(4''-N,N-Dimethyla...)
Affinity DataIC50: 12nMAssay Description:Tested for inhibition of polymerization of tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50112256(3,4,5-Trimethoxy-benzaldehyde O-(8-hydroxy-5-methy...)
Affinity DataIC50: 170nMAssay Description:Ability to inhibit the GTP/glutamate-induced polymerization of tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50139772(leurocristine | 22-oxovincaleukoblastine | vincris...)
Affinity DataIC50: 220nMAssay Description:The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay.More data for this Ligand-Target Pair
In DepthDetails Article

TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50280140([6-(3,4,5-Trimethoxy-benzyloxy)-imidazo[1,2-b]pyri...)
Affinity DataIC50: 310nMAssay Description:In vitro mammalian brain tubulin polymerization using standard assay.More data for this Ligand-Target Pair
In DepthDetails Article

TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037463(2-(3-Methoxy-phenyl)-6-morpholin-4-yl-1H-quinolin-...)
Affinity DataIC50: 363nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037454(6-(3-Chloro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin...)
Affinity DataIC50: 372nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037448(6-Dimethylamino-2-(3-methoxy-phenyl)-1H-quinolin-4...)
Affinity DataIC50: 380nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037450(2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin...)
Affinity DataIC50: 437nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50409014(CHEMBL50139)
Affinity DataIC50: 447nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50106309(2-(2-fluorophenyl)-6-(pyrrolidin-1-yl)quinolin-4(1...)
Affinity DataIC50: 457nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50035218(podophyllotoxin | CHEMBL61 | Podophyllinic acid la...)
Affinity DataIC50: 460nMAssay Description:Inhibition of tubulin polymerization. (ITP)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037462(6-(3-Hydroxy-phenyl)-5H-[1,3]dioxolo[4,5-g]quinoli...)
Affinity DataIC50: 468nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50070107((E)-3-(3''-Hydroxy-4''-methoxyphenyl)-2-methyl-1-(...)
Affinity DataIC50: 500nMAssay Description:Concentration that cause a 50% inhibition in tubulin assembly as measured by an increase in turbidity using microtubule assembly assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059968(2-(3-fluorophenyl)-7-methyl-1,8-naphthyridin-4(1H)...)
Affinity DataIC50: 525nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037457(6-(3-Fluoro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin...)
Affinity DataIC50: 525nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50005480(combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...)
Affinity DataIC50: 530nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059964(6-methyl-2-(naphthalen-1-yl)-1,8-naphthyridin-4(1H...)
Affinity DataIC50: 550nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50056948(Isonicotinic acid 1,2,3-trimethoxy-10-methylsulfan...)
Affinity DataIC50: 562nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037444(6-(3-Methoxy-phenyl)-5H-[1,3]dioxolo[4,5-g]quinoli...)
Affinity DataIC50: 575nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50409024(CHEMBL48525)
Affinity DataIC50: 617nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059971(2-(3-Fluoro-phenyl)-6-methyl-1H-[1,8]naphthyridin-...)
Affinity DataIC50: 631nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding siteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037459(6-(3-Methylamino-phenyl)-5H-[1,3]dioxolo[4,5-g]qui...)
Affinity DataIC50: 646nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50: 646nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059966(7-Methyl-2-naphthalen-1-yl-1H-[1,8]naphthyridin-4-...)
Affinity DataIC50: 661nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50041119(2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-on...)
Affinity DataIC50: 680nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50063845((S)-6-(3-Methoxy-phenyl)-6,7-dihydro-5H-[1,3]dioxo...)
Affinity DataIC50: 692nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059961(2-(3-Chloro-phenyl)-6-methyl-1H-[1,8]naphthyridin-...)
Affinity DataIC50: 724nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50409011(CHEMBL45711)
Affinity DataIC50: 724nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037453(6-(3-Amino-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-...)
Affinity DataIC50: 724nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059975(2-(3-Fluoro-phenyl)-5,7-dimethyl-1H-[1,8]naphthyri...)
Affinity DataIC50: 741nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50056949(Nicotinic acid 1,2,3-trimethoxy-10-methylsulfanyl-...)
Affinity DataIC50: 759nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059117(2-(3-Methoxy-phenyl)-7-methyl-1H-[1,8]naphthyridin...)
Affinity DataIC50: 759nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059978(5,7-Dimethyl-2-naphthalen-1-yl-1H-[1,8]naphthyridi...)
Affinity DataIC50: 776nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059976(2-(3-Chloro-phenyl)-5,7-dimethyl-1H-[1,8]naphthyri...)
Affinity DataIC50: 776nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059111(2-(3-Methoxy-phenyl)-6-methyl-1H-[1,8]naphthyridin...)
Affinity DataIC50: 794nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50014846(7alphaH-colchicine | (S)-N-(5,6,7,9-tetrahydro-1,2...)
Affinity DataIC50: 800nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50037447(6-(3-Trifluoromethyl-phenyl)-5H-[1,3]dioxolo[4,5-g...)
Affinity DataIC50: 813nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50090045((2,3-Dihydroxy-4-methoxy-phenyl)-(3,4,5-trimethoxy...)
Affinity DataIC50: 820nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50020475(CHEMBL341192 | [7-Methyl-5-(thiophene-2-carbonyl)-...)
Affinity DataIC50: 860nMAssay Description:Displacement of 5.8 uM [3H]-oncodazole from homogeneous tubulin.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059103(2-(3-Methoxy-phenyl)-5,7-dimethyl-1H-[1,8]naphthyr...)
Affinity DataIC50: 871nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50020464(CHEMBL135161 | [5-(2-Methoxycarbonylamino-1H-benzo...)
Affinity DataIC50: 880nMAssay Description:Displacement of 5.8 uM [3H]-oncodazole from homogeneous tubulin.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059960(2-(3-Chloro-phenyl)-7-methyl-1H-[1,8]naphthyridin-...)
Affinity DataIC50: 891nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059972(5-Methyl-2-naphthalen-1-yl-1H-[1,8]naphthyridin-4-...)
Affinity DataIC50: 933nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059122(2-(3-Methoxy-phenyl)-1H-[1,8]naphthyridin-4-one | ...)
Affinity DataIC50: 955nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50005480(combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50103820([2-(3-Hydroxy-4-methoxy-phenyl)-thiophen-3-yl]-(3,...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was evaluated for inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50409007(CHEMBL49419)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50059969(2-Naphthalen-1-yl-1H-[1,8]naphthyridin-4-one | CHE...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50090044(combretastatins A-1 | 3-Methoxy-6-[(Z)-2-(3,4,5-tr...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of Manchester Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50005480(combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antitubulin activity against tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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