Compile Data Set for Download or QSAR
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TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50148911(3beta-hydroxyurs-12-en-28-oic acid | (3beta)-3-hyd...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM46568((2Z)-7-chloranyl-2-[(2E)-1-chloranyl-2-(3-chlorany...)
Affinity DataIC50: 428nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50599421(CHEMBL5185218)
Affinity DataIC50: 510nMAssay Description:Inhibition of recombinant human SENP1 catalytic domain using RanGAP1 as substrate preincubated for 10 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 520nMAssay Description:Inhibition of human SENP1 using AMC-tagged SUMO1 as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 520nMAssay Description:Inhibition of SENP1 (unknown origin) using AMC-tagged SUMO1 as fluorogenic substrate preincubated for 10 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM46568((2Z)-7-chloranyl-2-[(2E)-1-chloranyl-2-(3-chlorany...)
Affinity DataIC50: 654nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565393(CHEMBL4780770)
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565392(CHEMBL4791433)
Affinity DataIC50: 790nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94843(cid_42628166 | (R)-5-(benzo[d][1,3]dioxol-5-yl)-3-...)
Affinity DataIC50: 993nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565391(CHEMBL4792569)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50421700(CHEMBL5289965)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant His6 tagged SENP1 catalytic domain expressed in Escherichia coli BL21 (DE3) using SUMO1-AMC as substrate incubated fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94870(cid_53299662 | (2Z)-2-(1-cyclopentyl-2H-1,2,3,4-te...)
Affinity DataIC50: 1.05E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50394464(CHEMBL2159857)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94847((5R)-3-(3-chloro-2-hydroxyphenyl)-5-(4-fluoropheny...)
Affinity DataIC50: 1.14E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94846((5R)-3-(3-chloro-2-hydroxyphenyl)-5-(4-chloropheny...)
Affinity DataIC50: 1.15E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50394465(CHEMBL2159858)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM75839((5Z)-2-anilino-5-[(5-bromo-3-ethoxy-2-hydroxypheny...)
Affinity DataIC50: 1.18E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50421700(CHEMBL5289965)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant His6 tagged SENP1 catalytic domain expressed in Escherichia coli BL21 (DE3) using SUMO3-AMC as substrate incubated fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50346606(CHEMBL1797137)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of recombinant human SENP1 catalytic domain using RanGAP1 as substrate preincubated for 10 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94869((2Z)-2-(1-pentyl-2H-tetrazol-5-ylidene)benzo[g]qui...)
Affinity DataIC50: 1.29E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565378(CHEMBL4793952)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565398(CHEMBL4776158)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591767(CHEMBL5206456)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of SENP1 (unknown origin) assessed as reduction in deSUMOylation of RanGAP1-SUMO2 using RanGAP1-SUMO2 as substrate preincubated for 10 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50421691(CHEMBL5275516)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50421700(CHEMBL5289965)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant His6 tagged SENP1 catalytic domain expressed in Escherichia coli BL21 (DE3) using SUMO2-AMC as substrate incubated fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50421702(CHEMBL3236516)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human SENP1 catalytic domain assessed as reduction in deSUMOylation of RanGAP1-SUMO2 using RanGAP1-SUMO2 as substrate by fluorescence b...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50536673(CHEMBL4587307)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli preincubated for 15 mins followed by addition of SUM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human full-length recombinant SENP1More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of full-length recombinant human 6His-tagged SENP1 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50394468(CHEMBL2159859)
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94810(SMR000283017 | cid_780578 | 6-chloro-2-oxo-N-(2-th...)
Affinity DataIC50: 1.84E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50394466(CHEMBL2159862)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103828(SPI-03 | US11041859, Code SPI-03)
Affinity DataIC50: 1.86E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103826(SPI-01 | US9791447, Compound SPI-01 | US11041859, ...)
Affinity DataIC50: 1.88E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565346(CHEMBL4781794)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of human His-tagged SENP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using DUB-Glo as substrate preincubated for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli preincubated for 15 mins followed by addition of SUM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human SENP1 catalytic domain assessed as reduction in deSUMOylation of RanGAP1-SUMO2 using RanGAP1-SUMO2 as substrate by fluorescence b...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94872(SMR002134470 | (2E)-2-[1-(2,6-dimethylphenyl)-2H-1...)
Affinity DataIC50: 1.93E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94843(cid_42628166 | (R)-5-(benzo[d][1,3]dioxol-5-yl)-3-...)
Affinity DataIC50: 1.93E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.08E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565390(CHEMBL4780586)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of His-tagged human SENP1 (419 to 644 residues) expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM94870(cid_53299662 | (2Z)-2-(1-cyclopentyl-2H-1,2,3,4-te...)
Affinity DataIC50: 2.21E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM49568(MLS000583691 | cid_5739630 | acetic acid [4-chloro...)
Affinity DataIC50: 2.22E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103829(SPI-04 | US9791447, Compound SPI-04 | US11041859, ...)
Affinity DataIC50: 2.32E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50394467(CHEMBL2159861)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103829(SPI-04 | US9791447, Compound SPI-04 | US11041859, ...)
Affinity DataIC50: 2.40E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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