Compile Data Set for Download or QSAR
Report error Found 214 of ic50 data for polymerid = 397,50007820
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50315416((R)-3-((R)-2-Amino-3-((S)-3-hydroxy-1-methoxy-1-ox...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human TLR2 expressed in HEK-Blue-4 cells assessed as induction of NF-kappaB by SEAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50570373(CHEMBL4852939)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human TLR2 expressed in HEK-Blue cells assessed as inhibition of Pam3CSK4-induced TLR2/TLR1 activation by measuring decrease i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50570375(CHEMBL4856507)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human TLR2 expressed in HEK-Blue cells assessed as inhibition of Pam3CSK4-induced TLR2/TLR1 activation by measuring decrease i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50274716(Dodecanoic acid 3-{(S)-2-hexadecanoylamino-3-[hydr...)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50274718(Phosphoric acid 2-{(2S,3S)-2-[2-(5-benzyloxy-1H-in...)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50570372(CHEMBL4865889)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human TLR2 expressed in HEK-Blue cells assessed as inhibition of Pam3CSK4-induced TLR2/TLR1 activation by measuring decrease i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Mouse)
Keio University

Curated by ChEMBL
LigandPNGBDBM50399457(CHEMBL2179400)
Affinity DataIC50: 349nMAssay Description:Inhibition of biotin labelled Pam2CSK4 binding to mouse TLR2 Fc chimera protein after 45 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50590252(CHEMBL5186900)
Affinity DataIC50: 350nMAssay Description:Antagonist activity at human TLR2 in HEK-Blue hTLR2 cells assessed as inhibition of Pam3CSK4-induced receptor activation preincubated with Pam3CSK4 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50406601(CHEMBL5276854)
Affinity DataIC50: 361nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649710(3-fluoro-5-formyl-4-hydroxy- N-(6-(pyrrolidin-1-yl...)
Affinity DataIC50: 400nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50399457(CHEMBL2179400)
Affinity DataIC50: 426nMAssay Description:Inhibition of biotin labelled Pam2CSK4 binding to His tagged human TLR2 after 45 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50274717(Phosphoric acid (S)-2-(3-hydroxy-hexadecylcarbamoy...)
Affinity DataIC50: 460nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649721(3-fluoro-2-hydroxy-5-(1-(4- (trifluoromethyl)pheny...)
Affinity DataIC50: 500nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50590248(CHEMBL5202822)
Affinity DataIC50: 520nMAssay Description:Antagonist activity at human TLR2 in HEK-Blue hTLR2 cells assessed as inhibition of Pam3CSK4-induced receptor activation preincubated with Pam3CSK4 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetToll-like receptor 2(Mouse)
Keio University

Curated by ChEMBL
LigandPNGBDBM50552138(CHEMBL3935646)
Affinity DataIC50: 580nMAssay Description:Inhibition of Pam3CSK4-induced TLR1/TLR2 activation in mouse RAW 264.7 cells assessed as reduction in NO production incubated for 24 hrs by 2,3-diami...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649705(3-fluoro-5-formyl-4-hydroxy- N-(5-(3-(pyrrolidin-1...)
Affinity DataIC50: 600nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649747((3-fluoro-4-hydroxy-5-(((4- methylpiperazin-1- yl)...)
Affinity DataIC50: 600nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649722(2-hydroxy-3-methoxy-5-(1-(4- (trifluoromethyl)phen...)
Affinity DataIC50: 700nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649723(5-hydroxy-2-(2-(6-(pyrrolidin- 1-yl)pyridin-3-yl)t...)
Affinity DataIC50: 700nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649763(8-fluoro-4-hydroxy-3-(2- methoxyethyl)-6-(3-(4- (p...)
Affinity DataIC50: 800nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50175650(Dodecanoic acid (R)-1-{2-[(S)-3-({2-[2-carboxy-3-(...)
Affinity DataIC50: 900nMAssay Description:Antagonistic potency at TLR2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50274719(Dodecanoic acid 1-(2-{(S)-3-[(2-{(2S,3R)-3-carboxy...)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649697(3-fluoro-5-formyl-4-hydroxy- N-(5-phenylthiazol-2-...)
Affinity DataIC50: 900nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649711(3-fluoro-2-hydroxy-5-(4-(4- (pyrrolidin-1- yl)phen...)
Affinity DataIC50: 900nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649757(2-fluoro-6-formyl-4-(3-(4- (pyrrolidin-1-yl)phenyl...)
Affinity DataIC50: 900nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50175655(Dodecanoic acid (R)-1-{2-[(S)-3-({2-[2-carboxy-3-(...)
Affinity DataIC50: 950nMAssay Description:Antagonistic potency at TLR2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649704(3-fluoro-N-(5-(4- fluorophenyl)thiazol-2-yl)-5- fo...)
Affinity DataIC50: 1.00E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649719(3-fluoro-5-formyl-4-hydroxy- N-(5-(4- (trifluorome...)
Affinity DataIC50: 1.00E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649756(2-fluoro-6-formyl-4-(3-(4- (pyrrolidin-1-yl)phenyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Mouse)
Keio University

Curated by ChEMBL
LigandPNGBDBM50461184(CHEMBL4225423)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of biotin labelled Pam2CSK4 binding to mouse TLR2 Fc chimera protein after 45 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50590240(CHEMBL5188622)
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at human TLR2 in HEK-Blue hTLR2 cells assessed as inhibition of Pam3CSK4-induced receptor activation preincubated with Pam3CSK4 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50590244(CHEMBL5179649)
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at human TLR2 in HEK-Blue hTLR2 cells assessed as inhibition of Pam3CSK4-induced receptor activation preincubated with Pam3CSK4 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649748((3-fluoro-4-hydroxy-5- ((morpholinoimino)methyl) p...)
Affinity DataIC50: 1.10E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649749((E)-2-fluoro-6-(((4- methylpiperazin-1- yl)imino)m...)
Affinity DataIC50: 1.10E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50315417(((R)-3-(2-((R)-2-Amino-3-hydroxypropanamido)ethylt...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human TLR2 expressed in HEK-Blue-4 cells assessed as induction of NF-kappaB by SEAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649759(2-fluoro-6-formyl-4-(3-(4- (pyrrolidin-1-yl)phenyl...)
Affinity DataIC50: 1.20E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649762(8-fluoro-4-hydroxy-3-methyl- 6-(3-(4-(pyrrolidin-1...)
Affinity DataIC50: 1.20E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50175654(Tetradecanoic acid (R)-2-({2-[2-carboxy-3-(4-hydro...)
Affinity DataIC50: 1.25E+3nMAssay Description:Antagonistic potency at TLR2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649724(3-fluoro-2-hydroxy-5-(3-(6- (pyrrolidin-1-yl)pyrid...)
Affinity DataIC50: 1.30E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Mouse)
Keio University

Curated by ChEMBL
LigandPNGBDBM50461188(CHEMBL4226256)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of biotin labelled Pam2CSK4 binding to mouse TLR2 Fc chimera protein after 45 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649706(3-fluoro-5-formyl-4-hydroxy- N-(5-(4-(pyrrolidin-1...)
Affinity DataIC50: 1.50E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649751(3-fluoro-5-formyl-4-hydroxy- N-(3-(4-(pyrrolidin-1...)
Affinity DataIC50: 1.50E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649758(2-fluoro-6-formyl-4-(3-(4- (pyrrolidin-1-yl)phenyl...)
Affinity DataIC50: 1.50E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50175651(Dodecanoic acid (R)-1-{2-[(R)-3-({2-[2-carboxy-3-(...)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonistic activity at TLR in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50570360(CHEMBL4846103)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human TLR2 expressed in HEK-Blue cells assessed as inhibition of Pam3CSK4-induced TLR2/TLR1 activation by measuring decrease i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649703(N-(3-fluoro-5-formyl-4- hydroxyphenyl)-5- phenylth...)
Affinity DataIC50: 1.60E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM649761(2-(2-fluoro-6-formyl-4-(3-(4- (pyrrolidin-1-yl)phe...)
Affinity DataIC50: 1.60E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50461184(CHEMBL4225423)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of biotin labelled Pam2CSK4 binding to His tagged human TLR2 after 45 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50570361(CHEMBL4876723)
Affinity DataIC50: 1.80E+3nMAssay Description:Antagonist activity at human TLR2 expressed in HEK-Blue cells assessed as inhibition of Pam3CSK4-induced TLR2/TLR1 activation by measuring decrease i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetToll-like receptor 2(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50461188(CHEMBL4226256)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of biotin labelled Pam2CSK4 binding to His tagged human TLR2 after 45 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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