Compile Data Set for Download or QSAR
Report error Found 490 of ic50 data for polymerid = 3907
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189412(CHEMBL3827983)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189417(CHEMBL3828116)
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189435(CHEMBL3828003)
Affinity DataIC50: 0.600nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50191472(CHEMBL3956719)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189436(CHEMBL3827327)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataIC50: 1.40nMAssay Description:Displacement of tracer 236 from recombinant human CDK8 incubated for 60 mins by TR-FRET based Lanthascreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163767(CHEMBL3798944)
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163774(CHEMBL3797855)
Affinity DataIC50: 1.70nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50: 1.70nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163857(CHEMBL3798853)
Affinity DataIC50: 1.90nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189420(CHEMBL3827799)
Affinity DataIC50: 2nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50191373(CHEMBL3966985)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50573483(CHEMBL4877883)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163854(CHEMBL3799581)
Affinity DataIC50: 2.10nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163777(CHEMBL3799307)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163795(CHEMBL3798382)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163855(CHEMBL3799212)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163795(CHEMBL3798382)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163771(CHEMBL3800311)
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163772(CHEMBL3797571)
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163781(CHEMBL3798987)
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189421(CHEMBL3827118)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM692580(US20240270735, Compound A156)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163755(CHEMBL3799396)
Affinity DataIC50: 2.70nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163784(CHEMBL3798804)
Affinity DataIC50: 2.80nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163789(CHEMBL3799824)
Affinity DataIC50: 2.80nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50191414(CHEMBL3947140)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM154576(K03861 (1))
Affinity DataIC50: 3nMAssay Description:Inhibition of NanoLuc-fused CDK8 (unknown origin) expressed in human HEK293 cells using NanoGlo substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163790(CHEMBL3799592)
Affinity DataIC50: 3.20nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163785(CHEMBL3797440)
Affinity DataIC50: 3.30nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163850(CHEMBL3798726)
Affinity DataIC50: 3.30nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189413(CHEMBL3827774)
Affinity DataIC50: 3.40nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163773(CHEMBL3797317)
Affinity DataIC50: 3.70nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163765(CHEMBL3799116)
Affinity DataIC50: 3.80nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163779(CHEMBL3798632)
Affinity DataIC50: 3.90nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM692509(US20240270735, Compound A69)
Affinity DataIC50: 4nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM692569(US20240270735, Compound A144)
Affinity DataIC50: 4nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163783(CHEMBL3799679)
Affinity DataIC50: 4.20nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189428(CHEMBL3828458)
Affinity DataIC50: 4.20nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163848(CHEMBL3800037)
Affinity DataIC50: 4.30nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163782(CHEMBL3797495)
Affinity DataIC50: 4.5nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50579915(CHEMBL4442570)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of CDK8 in human HEK293 cells measured by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189414(CHEMBL3828209)
Affinity DataIC50: 4.60nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189434(CHEMBL3828221)
Affinity DataIC50: 4.70nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189442(CHEMBL3828503)
Affinity DataIC50: 4.70nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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