Compile Data Set for Download or QSAR
Report error Found 237 of ic50 data for polymerid = 387
LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 0.800nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322528(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 1nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322529(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 1.10nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 1.40nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 1.5nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322518(5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-di...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322525(5-[3[4-(4-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]o...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322528(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322529(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322530(5-[3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322531(5-[3-[5-(3-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322532(5-[3-[4-(benzofuran-3-yl)-1H-imidazol-2-yl]chroman...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322533(5-[3-[5-(3-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322535(5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]chroman-...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322536(5-[3-[5-(1,3-benzodioxol-5-yl)-1H-imidazol-2-yl]ch...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322540(5-[3-(5-phenyl-1H-pyrazol-3-yl)chroman-6-yl]oxy-3,...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322541(5-[[(3S)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322542(5-[[(3R)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
Affinity DataIC50: 4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313753(US10167282, Compound TBAP-04)
Affinity DataIC50: 8nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313751(US10167282, Compound TBAP-02)
Affinity DataIC50: 12nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313750(US10167282, Compound TBAP-01)
Affinity DataIC50: 18nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313752(US10167282, Compound TBAP-03)
Affinity DataIC50: 19nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313753(US10167282, Compound TBAP-04)
Affinity DataIC50: 47nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322519(5-[3-(7-chloro-1H-benzimidazol-2-yl]chroman-6-yl]o...)
Affinity DataIC50: 52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322527(5-[3-(4-tert-butyl-1H-imidazol-2-yl)chroman-6-yl]o...)
Affinity DataIC50: 52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322537(5-[3-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imid...)
Affinity DataIC50: 52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322538(5-[[3-(4-phenyl-1H-imidazol-2-yl)-2H-chromen-6-yl]...)
Affinity DataIC50: 52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322539(5-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)chroman-6-yl]o...)
Affinity DataIC50: 52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322547(2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6...)
Affinity DataIC50: 52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313464(N-(5'-(3-fluorooxetan-3- yl)-6'-methoxy-2- methyl-...)
Affinity DataIC50: 59.3nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313750(US10167282, Compound TBAP-01)
Affinity DataIC50: 62nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313751(US10167282, Compound TBAP-02)
Affinity DataIC50: 99nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM322534(5-[3-[5-(4-methylsulfonylphenyl)-1H-imidazol-2-yl]...)
Affinity DataIC50: 100nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313752(US10167282, Compound TBAP-03)
Affinity DataIC50: 130nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313484(2-(1,1-difluoroethyl)-N- (3-(5-(3- (fluoromethyl)o...)
Affinity DataIC50: 293nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313400(N-(3-(6-ethoxy-5-(3- methyloxetan-3- yl)pyridin-3-...)
Affinity DataIC50: 304nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313486(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Affinity DataIC50: 323nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313754(US10167282, Compound TBAP-05)
Affinity DataIC50: 390nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313485(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Affinity DataIC50: 417nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313307(2-(2-cyanopropan-2-yl)- N-(3-(6-ethoxy-5-(3- (fluo...)
Affinity DataIC50: 446nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313754(US10167282, Compound TBAP-05)
Affinity DataIC50: 450nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313333(N-(5'-(3- (fluoromethyl)oxetan-3- yl)-6'-methoxy-2...)
Affinity DataIC50: 469nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313487(2-(2-cyanopropan-2-yl)- N-(3-(5-(3- (fluoromethyl)...)
Affinity DataIC50: 580nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM188175(US9670203, Compound 1.35)
Affinity DataIC50: 590nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM189798(US9670203, Compound 1.51)
Affinity DataIC50: 590nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM313396(N-(6'-ethoxy-2-methyl- 5'-(3-methyloxetan-3- yl)-[...)
Affinity DataIC50: 613nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM186830(US9670203, Compound 1.57 | US9670203, Compound 1.2...)
Affinity DataIC50: 710nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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