Compile Data Set for Download or QSAR
Report error Found 163 of ic50 data for polymerid = 3629,7888,11048,49000190,49000199,49000200,49000203
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM29568([3H]-Minipress | [3H]-Furazosin | PRAZOSIN HYDROCH...)
Affinity DataIC50: 0.190nMAssay Description:Displacement of [3H]prazosin from adrenergic Alpha-1B receptor in Wistar rat liver membrane after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM29568([3H]-Minipress | [3H]-Furazosin | PRAZOSIN HYDROCH...)
Affinity DataIC50: 0.851nMAssay Description:Displacement of [3H]prazosin from rat liver adrenergic alpha1B receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50091350(CHEMBL3582270)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50057463(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50063906((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-1-(f...)
Affinity DataIC50: 3.20nMAssay Description:Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtypeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50063906((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-1-(f...)
Affinity DataIC50: 3.20nMAssay Description:Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtypeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50060964(5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]...)
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity at human alpha1B receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50060964(5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]...)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at human full-length N-terminal SNAP-tagged alpha1B adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-indu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50091351(CHEMBL3582269)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50091352(CHEMBL3582268)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50393116(CHEMBL2153423)
Affinity DataIC50: 6.03nMAssay Description:Displacement of [3H]prazosin from rat liver adrenergic alpha1B receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 8.80nMAssay Description:Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 9.30nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtype.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 9.30nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50565737(CHEMBL4785526)
Affinity DataIC50: 9.80nMAssay Description:Antagonist activity at human alpha1B receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50500011(CHEMBL3739533)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50063906((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-1-(f...)
Affinity DataIC50: 14nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtypeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50063906((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-1-(f...)
Affinity DataIC50: 15nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50091349(CHEMBL3582271)
Affinity DataIC50: 16nMAssay Description:Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50500006(CHEMBL3742253)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50057462(8-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyryl...)
Affinity DataIC50: 24nMAssay Description:Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50: 24nMAssay Description:Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50057449(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50: 29nMAssay Description:Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50499996(CHEMBL3740019)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataIC50: 31nMAssay Description:Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50500003(CHEMBL3742103)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50172997(CHEMBL3808726)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50500016(CHEMBL3740874)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50172992(CHEMBL3809248)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50057453(8-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butoxy}...)
Affinity DataIC50: 39nMAssay Description:Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50091348(CHEMBL3582272)
Affinity DataIC50: 52nMAssay Description:Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50173112(CHEMBL3810110)
Affinity DataIC50: 71nMAssay Description:Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50057496(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50: 79nMAssay Description:Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50160154(CHEMBL24778 | 1-(3-Hydroxy-propyl)-5-((R)-2-{2-[2-...)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at alpha1B adrenoceptor in Sprague-Dawley rat aorta assessed as inhibition of norepinephrine-induced smooth muscle contraction af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50500015(CHEMBL3741318)
Affinity DataIC50: 101nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50299208(4-amino-6-methyl-2-(3-(4-p-tolylpiperazin-1-yl)pro...)
Affinity DataIC50: 102nMAssay Description:Displacement of [3H]prazosin from adrenergic Alpha-1B receptor in Wistar rat liver membrane after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50057456(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50: 108nMAssay Description:Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50160154(CHEMBL24778 | 1-(3-Hydroxy-propyl)-5-((R)-2-{2-[2-...)
Affinity DataIC50: 116nMAssay Description:Antagonist activity at human full-length N-terminal SNAP-tagged alpha1B adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-indu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50500013(CHEMBL3740558)
Affinity DataIC50: 122nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50173109(CHEMBL3809093)
Affinity DataIC50: 131nMAssay Description:Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50421597(CHEMBL155327)
Affinity DataIC50: 132nMAssay Description:In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50421641(CHEMBL277375)
Affinity DataIC50: 158nMAssay Description:Inhibitory concentration against radioligand binding to human Alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50173113(CHEMBL3809630)
Affinity DataIC50: 159nMAssay Description:Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50421602(CHEMBL351542)
Affinity DataIC50: 162nMAssay Description:In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50173004(CHEMBL3808896)
Affinity DataIC50: 169nMAssay Description:Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50173100(CHEMBL3809794)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50173101(CHEMBL3808572)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50499998(CHEMBL3739762)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50500007(CHEMBL3742276)
Affinity DataIC50: 199nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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