Compile Data Set for Download or QSAR
Report error Found 63 of ic50 data for polymerid = 343,50001120
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.168nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.168nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50435962(CHEMBL2391655)
Affinity DataIC50: 31nMAssay Description:Inhibition of KCa2.3 (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 56nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 59nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50150389(17,23-diazonia-2,9-diazahexacyclo[21.6.2.24,7.210,...)
Affinity DataIC50: 60nMAssay Description:Inhibition of KCa2.3 (unknown origin)More data for this Ligand-Target Pair
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PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215069(1,2,3-tris-[3-(4-(N-ethyl)-quinoliniumylamino)-pro...)
Affinity DataIC50: 86nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215071(N-[3-(4-quinolinylamino)-propyl]-N-[5-(4-quinoliny...)
Affinity DataIC50: 93nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215076(N-[3-(4-quinolinylamino)-propyl]-N-[5-(4-quinoliny...)
Affinity DataIC50: 130nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
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PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215070(1,2,3-tri[3-(4-quinolinylamino)-propoxy]-benzene |...)
Affinity DataIC50: 130nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215075(N-[3-(4-quinolinylamino)-propyl]-3,5-di-[3-(4-quin...)
Affinity DataIC50: 220nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215072(N-(4-quinolinyl)-3,4-di-[3-(4-quinolinylamino)-pro...)
Affinity DataIC50: 270nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 290nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275960(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215068(N-[3-(4-quinolinylamino)-proyl]-3,5-di[3-(4-quinol...)
Affinity DataIC50: 360nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215073(N-[3-(4-quinolinyl)-aminopropyl]-N-(8-aminooctyl)-...)
Affinity DataIC50: 490nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 543nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275960(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 580nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275958((R)-5-chloro-N-(1-phenylethyl)pyrazolo[1,5-a]pyrim...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275792(N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine ...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50048403(dequalinium | 1-[10-(4-amino-2-methyl-1-quinoliniu...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275792(N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine ...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50048403(dequalinium | 1-[10-(4-amino-2-methyl-1-quinoliniu...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50356161(CHEMBL1909931)
Affinity DataIC50: 2.97E+3nMAssay Description:Inhibition of cloned human SK3 channel expressed in human HEK293 cells by patch clamp assay in the presence of 1 uM intracellular Ca2+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50377863(AG-525 | CHEMBL257156)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of SK3 expressed in CHO FlipIn cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50275798(5-chloro-N-(3-chlorobenzyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50377980(CHEMBL558625)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50275959(5-chloro-N-(1,2-diphenylethyl)pyrazolo[1,5-a]pyrim...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275853(5-chloro-N-(3-nitrobenzyl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275797(5-chloro-N-(2-(trifluoromethoxy)benzyl)pyrazolo[1,...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275850(5-chloro-N-(3-methylbenzyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275852(5-chloro-N-(3-(trifluoromethoxy)benzyl)pyrazolo[1,...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275851(5-chloro-N-(3-(trifluoromethyl)benzyl)pyrazolo[1,5...)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275794(5-chloro-N-(2-methylbenzyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275907(5-chloro-N-(4-(trifluoromethoxy)benzyl)pyrazolo[1,...)
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275796(5-chloro-N-(2-methoxybenzyl)pyrazolo[1,5-a]pyrimid...)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215074(N-(3-guanidinopropyl)-N-[4-(4'-aminomethylphenyl)]...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275793(5-chloro-N-(2-chlorobenzyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215079(4,4'bis(guanidinomethyl)-cis-stilbene | CHEMBL2291...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rat)
University College London

Curated by ChEMBL
LigandPNGBDBM50215078(N-(3-guanidinopropyl)-N(8-aminooctyl)-3-[(N'-(N''-...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275854(5-chloro-N-(4-chlorobenzyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50263326(3-chloro-N-(4-(pyridin-2-yl)thiazol-2-yl)-5-(trifl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275855(5-chloro-N-(4-methylbenzyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50275906(5-chloro-N-(4-(trifluoromethyl)benzyl)pyrazolo[1,5...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50264070(cid_704624 | CHEMBL492010 | N-(4-(pyridin-3-yl)thi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50264071(cid_704533 | CHEMBL452409 | N-(4-(pyridin-4-yl)thi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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