Compile Data Set for Download or QSAR
Report error Found 202 of ic50 data for polymerid = 2444,49000963,49000964
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095207([6-(4-Benzhydryl-pyrazol-1-ylmethyl)-7,8-dihydro-n...)
Affinity DataIC50: 8nMAssay Description:Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost f...More data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 8.40nMAssay Description:Binding affinity to human PGI2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 9nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284372({5-[2-(N',N'-Diphenyl-hydrazinocarbonyl)-ethyl]-5,...)
Affinity DataIC50: 10nMAssay Description:Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235375(CHEMBL3975122)
Affinity DataIC50: 12nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50163291(CHEMBL3793903)
Affinity DataIC50: 13nMAssay Description:Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 13nMAssay Description:Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284377({5-[2-(4-Benzhydryl-pyrazol-1-yl)-ethyl]-5,6,7,8-t...)
Affinity DataIC50: 18nMAssay Description:Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost f...More data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataIC50: 18nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235378(CHEMBL3981509)
Affinity DataIC50: 19nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284370([6-(N',N'-Diphenyl-hydrazinocarbonylmethyl)-5,6,7,...)
Affinity DataIC50: 20nMAssay Description:Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235368(CHEMBL3893346)
Affinity DataIC50: 22nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235376(CHEMBL3926078)
Affinity DataIC50: 23nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235373(CHEMBL3928729)
Affinity DataIC50: 23nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50016954(CHEMBL1628262)
Affinity DataIC50: 25nMAssay Description:Agonist activity at prostanoid IP receptor (unknown origin) by functional assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235367(CHEMBL3952237)
Affinity DataIC50: 25nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 27nMAssay Description:Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 27nMAssay Description:Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235389(CHEMBL3983767)
Affinity DataIC50: 30nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM85602((R)-BUTAPROST | CAS_69648-38-0 | Butaprost (Free A...)
Affinity DataIC50: 37nMAssay Description:Agonist activity at prostanoid IP receptor (unknown origin) by functional assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 38nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50191135(sodium 2-(3-(((1S,2R)-2-(4,5-diphenyloxazol-2-yl)c...)
Affinity DataIC50: 39nMAssay Description:Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235374(CHEMBL3935924)
Affinity DataIC50: 39nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284378([6-(4-Benzhydryl-pyrazol-1-ylmethyl)-5,6,7,8-tetra...)
Affinity DataIC50: 40nMAssay Description:Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost f...More data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235379(CHEMBL3932106 | US10668033, Compound 55)
Affinity DataIC50: 43nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50191133(sodium (R)-2-(3-((2-(4,5-diphenyloxazol-2-yl)pyrro...)
Affinity DataIC50: 48nMAssay Description:Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23960(5-{[4-(3-acetamidophenyl)phenyl]methyl}-N-[(2R)-2-...)
Affinity DataIC50: 53nM EC50:  51nMpH: 7.4 T: 2°CAssay Description:IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50191134(sodium 2-(3-(((1S,2S)-2-(4,5-diphenyloxazol-2-yl)c...)
Affinity DataIC50: 53nMAssay Description:Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235384(CHEMBL3900038)
Affinity DataIC50: 54nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235372(CHEMBL3966307)
Affinity DataIC50: 54nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50191132(sodium (S)-2-(3-((2-(4,5-diphenyloxazol-2-yl)pyrro...)
Affinity DataIC50: 58nMAssay Description:Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50136234(Sodium; {3-[(R)-2-(4,5-diphenyl-oxazol-2-yl)-cyclo...)
Affinity DataIC50: 60nMAssay Description:Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50103395(CHEMBL3398235)
Affinity DataIC50: 62nMAssay Description:Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50103396(CHEMBL3398236)
Affinity DataIC50: 62nMAssay Description:Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235383(ACT-293987 | NS-304 | Selexipag | Uptravi)
Affinity DataIC50: 62nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50103394(CHEMBL3398229)
Affinity DataIC50: 64nMAssay Description:Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23953(5-{[4-(3-acetamidophenyl)phenyl]methyl}-N-(2-pheny...)
Affinity DataIC50: 77nMpH: 7.4 T: 2°CAssay Description:IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095203([(S)-6-(3-Benzhydryl-6-oxo-6H-pyridazin-1-ylmethyl...)
Affinity DataIC50: 81nMAssay Description:Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095203([(S)-6-(3-Benzhydryl-6-oxo-6H-pyridazin-1-ylmethyl...)
Affinity DataIC50: 81nMAssay Description:Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50103404(CHEMBL3398228)
Affinity DataIC50: 87nMAssay Description:Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235371(CHEMBL3922000)
Affinity DataIC50: 93nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50191137(sodium 2-(3-(((1S,2R)-2-(4,5-diphenyloxazol-2-yl)c...)
Affinity DataIC50: 114nMAssay Description:Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50191138(sodium 2-(3-(((1S,2S)-2-(4,5-diphenyloxazol-2-yl)c...)
Affinity DataIC50: 115nMAssay Description:Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50163296(CHEMBL3793911)
Affinity DataIC50: 130nMAssay Description:Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50235377(CHEMBL3890685)
Affinity DataIC50: 142nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284366((6-{2-[(E)-Benzhydryloxyimino]-butyl}-5,6,7,8-tetr...)
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095205([6-(2-Benzhydryloxyimino-pentyl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50002404(CHEMBL118567 | 9-(3,4,5-Triphenyl-pyrazol-1-yl)-no...)
Affinity DataIC50: 160nMAssay Description:IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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