Compile Data Set for Download or QSAR
Report error Found 587 of ic50 data for polymerid = 2436,2906,5909,50001191,50002980
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM535882(US11242312, Example 3)
Affinity DataIC50: 0.00800nMAssay Description:Activity of Calpain 1 was measured by using Calpain-Glo Protease kit from Promega. Assays were run in 384-well black plates with clear bottom. 5 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM535880(US11242312, Example 1)
Affinity DataIC50: 0.0300nMAssay Description:Activity of Calpain 1 was measured by using Calpain-Glo Protease kit from Promega. Assays were run in 384-well black plates with clear bottom. 5 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50142284(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibitory activity tested against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM535881(US11242312, Example 2)
Affinity DataIC50: 2.20nMAssay Description:Activity of Calpain 1 was measured by using Calpain-Glo Protease kit from Promega. Assays were run in 384-well black plates with clear bottom. 5 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50245477(CHEMBL4073900)
Affinity DataIC50: 3nMAssay Description:Inhibition of human calpain 1 protease using Ac-LLY-AFC as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291219([(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2,2-...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291234([(S)-1-((S)-1-Formyl-2-methyl-propylcarbamoyl)-3-m...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105236(6-Chloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro-1la...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291225({(S)-1-[(R)-1-((R)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50084655([(S)-1-((S)-1-Formyl-pentylcarbamoyl)-3-methyl-but...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50142302(6-Chloro-2-ethyl-1,1-dioxo-1,2,3,4-tetrahydro-1lam...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against human calpain I; Not determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105229(2-Methyl-1,1-dioxo-1,2,6,7-tetrahydro-5,8-dioxa-1l...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50101321([(S)-1-((S)-1-Benzyl-2-benzyloxycarbamoyl-2-oxo-et...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291188(((S)-1-{(R)-1-[(S)-1-((S)-1-Formyl-3-methyl-butylc...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50066991((R)-2-(2-Benzyloxycarbonylamino-4-methyl-pentanoyl...)
Affinity DataIC50: 7nMAssay Description:inhibitory activity measured against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105231(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105241(6,7-Dichloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291222({(S)-1-[(S)-1-(4-Benzyloxy-benzyl)-2-oxo-ethylcarb...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50142283(1,1-Dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[e][1...)
Affinity DataIC50: 7nMAssay Description:In vitro inhibitory activity against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105231(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-...)
Affinity DataIC50: 7nMAssay Description:In vitro inhibitory activity against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM535883(US11242312, Example 4)
Affinity DataIC50: 7.10nMAssay Description:Activity of Calpain 1 was measured by using Calpain-Glo Protease kit from Promega. Assays were run in 384-well black plates with clear bottom. 5 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50: 7.5nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Rat)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50114340(N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal | (S...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105244(2-Ethyl-1,1-dioxo-1,2,6,7-tetrahydro-5,8-dioxa-1la...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291228([(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-me...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291236([(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-me...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291192([(S)-1-[(R)-1-((R)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105244(2-Ethyl-1,1-dioxo-1,2,6,7-tetrahydro-5,8-dioxa-1la...)
Affinity DataIC50: 8nMAssay Description:In vitro inhibitory activity against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50104576([(S)-1-((S)-1-Benzyl-2-methoxycarbamoyl-2-oxo-ethy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50124017(N-(1-Formyl-3-methyl-butyl)-3-methyl-2-(naphthalen...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291218([(S)-1-(1-Formyl-propylcarbamoyl)-3-methyl-butyl]-...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50137397([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-3-methy...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291223(Naphthalene-2-carboxylic acid {(S)-1-[(R)-1-((R)-1...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291194((S)-2-Methanesulfonylamino-4-methyl-pentanoic acid...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Rat)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358131(CHEMBL1923954)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065407((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-met...)
Affinity DataIC50: 11nMAssay Description:Compound was tested for inhibitory activity against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105230(N-(1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-methanesulf...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against calpain-IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50142287((S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291226([(S)-1-((S)-1-Cyclohexylmethyl-2-oxo-ethylcarbamoy...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50073850([(S)-1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-pr...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity using recombinant human Calpain 1 with Suc-Leu-Tyr-MNA as substrate.More data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291187({(S)-1-[(R)-1-((R)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291197([(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-me...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50142287((S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50104586([(R)-1-((S)-1-Benzyl-2-benzyloxycarbamoyl-2-oxo-et...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291205([(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-me...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291177((S)-2-Acetylamino-4-methyl-pentanoic acid [(R)-1-(...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291181({(S)-2-tert-Butoxy-1-[(R)-1-((R)-1-formyl-3-methyl...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50071828(Benzenesulfonic acid (3R,5S)-1-benzenesulfonyl-5-(...)
Affinity DataIC50: 13nMAssay Description:Compound was tested for inhibitory activity against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50124024(2-(4-Chloro-benzenesulfonylamino)-N-[1-formyl-2-(1...)
Affinity DataIC50: 13nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Rat)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358138(CHEMBL1923961)
Affinity DataIC50: 13nMAssay Description:Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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