Compile Data Set for Download or QSAR
Report error Found 142 of ic50 data for polymerid = 2298,2980,49000659,49000660,49000663,49000664
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50: 0.870nMAssay Description:Inhibitory concentration against histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM22568([3H]tiotidine | 1-cyano-3-{2-[({2-[(diaminomethyli...)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]Aminopotentidine from human recombinant histamine H2 receptor expressed in CHOK1 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156855(3-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50: 123nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50403559(Brumetadina | CIMETIDINE)
Affinity DataIC50: 140nMAssay Description:Binding affinity to human histamine H2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 142nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156856(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50: 225nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156857(2-(2-(4-(1-(2-ethoxyethyl)-6-fluoro-1H-indol-3-yl)...)
Affinity DataIC50: 260nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50403559(Brumetadina | CIMETIDINE)
Affinity DataIC50: 270nMAssay Description:Binding affinity to human histamine H2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50036754(CHEMBL902 | N-sulfomoyl-3-(2-Guanidino-2H-1lambda*...)
Affinity DataIC50: 300nMAssay Description:Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atriumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105105({1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-y...)
Affinity DataIC50: 368nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213876(CHEMBL50524)
Affinity DataIC50: 442nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails

TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156878(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156892(2-(2-(4-(1-(thiophen-2-ylmethyl)-1H-indol-3-yl)pip...)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156900(2-(2-(4-(1-(2-ethoxyethyl)-5-fluoro-1H-indol-3-yl)...)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM181119(US9138393, Cimetidine | US9144538, Cimetidine)
Affinity DataIC50: 500nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156887(3-[4-(1-furan-2-ylmethyl-1H-indol-3-yl)piperidin-1...)
Affinity DataIC50: 630nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020712(CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...)
Affinity DataIC50: 660nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213878(CHEMBL301294)
Affinity DataIC50: 684nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails

TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156894(4-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50: 691nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 720nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213879(CHEMBL298354)
Affinity DataIC50: 747nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails

TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50: 757nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156893(2-(2-{4-[1-(2-ethoxyethyl)-1H-indol-3-yl]piperidin...)
Affinity DataIC50: 779nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213959(CHEMBL50294)
Affinity DataIC50: 809nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails

TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156875(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50: 850nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172421((E)-N-{2-[(2-Dimethylamino-ethyl)-methyl-amino]-4-...)
Affinity DataIC50: 860nMAssay Description:Inhibitory concentration against Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156886(2-{2-[4-(6-fluoro-1-furan-2-ylmethyl-1H-indol-3-yl...)
Affinity DataIC50: 870nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156876(2-{2-[4-(6-fluoro-1-furan-3-ylmethyl-1H-indol-3-yl...)
Affinity DataIC50: 880nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31005(MIANSERIN HYDROCHLORIDE | SMR000058472 | MLS000069...)
Affinity DataIC50: 880nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156890(5-acetyl-2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)...)
Affinity DataIC50: 950nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50103595(CHEBI:3699 | Brumetadina | Cimetidine | Tagamet | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50330441(3-amino-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)buty...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50103595(CHEBI:3699 | Brumetadina | Cimetidine | Tagamet | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]APT from human recombinant H2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50260582(CHEMBL4086541)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-aminopotentidine receptor from histamine H2 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM22889(N-methyl-N-[2-(5-methyl-1H-4-imidazolylmethylsulfa...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of guinea pig histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156861(2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-6-fluor...)
Affinity DataIC50: 1.03E+3nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105109(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213877(CHEMBL50523)
Affinity DataIC50: 1.05E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails

TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213880(CHEMBL50503)
Affinity DataIC50: 1.14E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails

TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156863(2-(2-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl...)
Affinity DataIC50: 1.19E+3nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105101(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213960(CHEMBL49928)
Affinity DataIC50: 1.27E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails

TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50036755(N-[6-(2-Guanidino-thiazol-4-yl)-pyridin-2-ylmethyl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atriumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156884(3-[4-(1-thiophen-2-ylmethyl-1H-indol-3-yl)piperidi...)
Affinity DataIC50: 1.33E+3nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156860(2-(2-(4-(7-bromo-1-(2-ethoxyethyl)-1H-indol-3-yl)p...)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156859(2-(2-(4-(5-bromo-1-(2-ethoxyethyl)-1H-indol-3-yl)p...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156877(5-[4-(6-fluoro-1-furan-3-ylmethyl-1H-indol-3-yl)pi...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156871(4-{4-[1-(2-ethoxyethyl)-1H-indol-3-yl]piperidin-1-...)
Affinity DataIC50: 1.77E+3nMAssay Description:Displacement of [3H]ketanserin from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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