Compile Data Set for Download or QSAR
Report error Found 1015 of ic50 data for polymerid = 2258,5790,50001608,50001908,50004806
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109578(CHEMBL3604156)
Affinity DataIC50: 1nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347329(CHEMBL1796851)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347323(CHEMBL1796845)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347327(CHEMBL1796849)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109729(CHEMBL3604185)
Affinity DataIC50: 2nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347324(CHEMBL1796846)
Affinity DataIC50: 2nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347327(CHEMBL1796849)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347328(CHEMBL1796850)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22266({ethyl[(3R)-1-[1-(4-fluorophenyl)ethyl]pyrrolidin-...)
Affinity DataIC50: 3nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347325(CHEMBL1796847)
Affinity DataIC50: 3nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347329(CHEMBL1796851)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347322(CHEMBL1796844)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109751(CHEMBL3604184)
Affinity DataIC50: 4nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347318(CHEMBL1796840)
Affinity DataIC50: 4nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347328(CHEMBL1796850)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347330(CHEMBL1795361)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347323(CHEMBL1796845)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347326(CHEMBL1796848)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22249(N-{2-[5-(4-methoxyphenyl)-2-(thiophen-2-yl)-1H-imi...)
Affinity DataIC50: 6nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22302(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50: 6nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347324(CHEMBL1796846)
Affinity DataIC50: 7nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347325(CHEMBL1796847)
Affinity DataIC50: 7nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347322(CHEMBL1796844)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22304(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Affinity DataIC50: 8nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347326(CHEMBL1796848)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347319(CHEMBL1796841)
Affinity DataIC50: 9nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22265({ethyl[(3R)-1-(2-phenylpropan-2-yl)pyrrolidin-3-yl...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22303(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22305(N-[2-(2-{8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22308(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50329324(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50329327(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50329325(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50329321(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50329328(4-(5-(naphthalen-2-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50329329(4-(5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-ylthio)but...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50329326(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109578(CHEMBL3604156)
Affinity DataIC50: 10nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347320(CHEMBL1796842)
Affinity DataIC50: 10nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM594030(US11584728, Compound E | Synthesis of 2-((R,6E,10E...)
Affinity DataIC50: 10nMAssay Description:Briefly, reactions were carried out in Corning 96 half-well black, flat bottom assay plates and contained final concentrations of 50 μM arachido...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22264({[(3R)-1-(3,4-dichlorophenyl)pyrrolidin-3-yl](meth...)
Affinity DataIC50: 11nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22299(4-pentyl-N-{2-[2-(4-propanoylphenyl)-1H-indol-3-yl...)
Affinity DataIC50: 11nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22300(4-pentyl-N-(2-{2-[4-(trifluoromethyl)phenyl]-1H-in...)
Affinity DataIC50: 11nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22312(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Affinity DataIC50: 11nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347317(CHEMBL1796839)
Affinity DataIC50: 11nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22314(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Affinity DataIC50: 12nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347321(CHEMBL1796843)
Affinity DataIC50: 12nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22306(4-pentyl-N-{2-[2-(quinolin-3-yl)-1H-indol-3-yl]eth...)
Affinity DataIC50: 13nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rat)
Institute For Bio-Medical Research

Curated by ChEMBL
LigandPNGBDBM50011938(CHEMBL37081 | 2-Cyano-3-(3,4-dihydroxy-phenyl)-acr...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against 12-lipoxygenase in rat platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of 15-LO-mediated 15-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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