Compile Data Set for Download or QSAR
Report error Found 325 of ic50 data for polymerid = 2257
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22218(1-[(4-{5-[4-(3,3,3-trifluoropropyl)phenyl]-1,2,4-o...)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22220(1-{[4-(5-{4-[(1R)-3,3-difluorocyclopentyl]phenyl}-...)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22215(1-({4-[5-(4-cyclopentylphenyl)-1,2,4-oxadiazol-3-y...)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22219(1-{[4-(5-{4-[(1S)-3,3-difluorocyclopentyl]phenyl}-...)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 0.550nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50152322({2-[5-(4-Nonyl-phenyl)-pyrrolidin-2-yl]-ethyl}-pho...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50152322({2-[5-(4-Nonyl-phenyl)-pyrrolidin-2-yl]-ethyl}-pho...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataIC50: 0.770nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50152337(2-amino-2-({[dihydroxy(oxido)--phosphanyl]oxy}meth...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22216(1-({4-[5-(4-cyclohexylphenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50: 0.800nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22209(1-[(4-{5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazo...)
Affinity DataIC50: 1nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22209(1-[(4-{5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazo...)
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499644(CHEMBL3741414)
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499639(CHEMBL3739440)
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499678(CHEMBL1973936)
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499651(CHEMBL1990223)
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499650(CHEMBL1966501)
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499687(CHEMBL3741092)
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50152328([(1S,3S)-3-(4-Nonyl-benzylamino)-cyclohexyl]-phosp...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50: 1.30nMAssay Description:I. Master Stock SolutionUnless specified otherwise, the sample compounds were diluted in 100% anhydrous DMSO including all dilutions. The compounds w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22206(1-({4-[5-(4-propylphenyl)-1,2,4-oxadiazol-3-yl]phe...)
Affinity DataIC50: 1.60nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22205(1-[(4-{5-[4-(2-methylbutan-2-yl)phenyl]-1,2,4-oxad...)
Affinity DataIC50: 1.80nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499648(CHEMBL3741572)
Affinity DataIC50: 2nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499670(CHEMBL1998478)
Affinity DataIC50: 2nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499683(CHEMBL3740009)
Affinity DataIC50: 2nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding based MFB methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499682(CHEMBL1986265)
Affinity DataIC50: 2nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50152329([1-(4-Nonyl-benzyl)-pyrrolidin-3-yl]-phosphonic ac...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM329368(US9663511, Compound 27. | US9663511, Compound 1.)
Affinity DataIC50: 2.20nMAssay Description:I. Master Stock SolutionUnless specified otherwise, the sample compounds were diluted in 100% anhydrous DMSO including all dilutions. The compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22207(1-({4-[5-(4-butylphenyl)-1,2,4-oxadiazol-3-yl]phen...)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50249114((S)-2-amino-2-methyl-3-oxo-3-(4-(5-phenylpentyloxy...)
Affinity DataIC50: 2.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499645(CHEMBL3740090)
Affinity DataIC50: 3nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499663(CHEMBL3740359)
Affinity DataIC50: 3nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 3.10nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR5 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 3.10nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 3.10nMAssay Description:Displacement of [32P]S1P from human recombinant S1PR5 incubated for 60 mins by competitive binding assay based scintillation counterMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)
Affinity DataIC50: 3.20nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM329369(US9663511, Compound 2.)
Affinity DataIC50: 3.20nMAssay Description:I. Master Stock SolutionUnless specified otherwise, the sample compounds were diluted in 100% anhydrous DMSO including all dilutions. The compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50249294((R)-2-amino-2-(4-(4-(5-phenylpentyloxy)phenyl)-1H-...)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22214(1-({4-[5-(4-cyclobutylphenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50: 4nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499658(CHEMBL1971132)
Affinity DataIC50: 4nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499685(CHEMBL1968499)
Affinity DataIC50: 4nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM329381(US9663511, Compound 38.)
Affinity DataIC50: 4.60nMAssay Description:I. Master Stock SolutionUnless specified otherwise, the sample compounds were diluted in 100% anhydrous DMSO including all dilutions. The compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499636(CHEMBL3741022)
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499637(CHEMBL3740093)
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499652(CHEMBL3740964)
Affinity DataIC50: 5nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding based MFB methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499653(CHEMBL3741298)
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50499654(CHEMBL3739878)
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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