Compile Data Set for Download or QSAR
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TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160957([3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethy...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against casp-2 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160974([3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethy...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against casp-2 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355101(CHEMBL1835324)
Affinity DataIC50: 22nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355110(CHEMBL1835208)
Affinity DataIC50: 41nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355111(CHEMBL1835210)
Affinity DataIC50: 41nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355109(CHEMBL1835209)
Affinity DataIC50: 46nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355103(CHEMBL1835399)
Affinity DataIC50: 50nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355094(CHEMBL1835317)
Affinity DataIC50: 50nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355102(CHEMBL1835325)
Affinity DataIC50: 60nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355099(CHEMBL1835322)
Affinity DataIC50: 86nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355112(CHEMBL1835211)
Affinity DataIC50: 108nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355097(CHEMBL1835320)
Affinity DataIC50: 136nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355098(CHEMBL1835321)
Affinity DataIC50: 150nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355107(CHEMBL1835403)
Affinity DataIC50: 163nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355093(CHEMBL1835316)
Affinity DataIC50: 219nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10284(4-oxo-4-(piperidin-1-yl)-N-(1,3,4-trioxo-1,2,3,4-t...)
Affinity DataIC50: 231nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10264(2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50: 233nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355089(CHEMBL1835212)
Affinity DataIC50: 246nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355090(CHEMBL1835313)
Affinity DataIC50: 413nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355095(CHEMBL1835318)
Affinity DataIC50: 441nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355091(CHEMBL1835314)
Affinity DataIC50: 453nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355106(CHEMBL1835402)
Affinity DataIC50: 459nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10278(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)
Affinity DataIC50: 530nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10287(N-(2-Methoxy-phenyl)-N-(1,3,4-trioxo-1,2,3,4-tetra...)
Affinity DataIC50: 537nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355108(CHEMBL1835404)
Affinity DataIC50: 573nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355111(CHEMBL1835210)
Affinity DataIC50: 635nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355092(CHEMBL1835315)
Affinity DataIC50: 772nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355098(CHEMBL1835321)
Affinity DataIC50: 781nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10280(N-(1,3,4-Trioxo-1,2,3,4-tetrahydro-isoquinolin-6-y...)
Affinity DataIC50: 859nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355099(CHEMBL1835322)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355109(CHEMBL1835209)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10247(1,2,3,4-tetrahydroisoquinoline-1,3,4-trione | Isoq...)
Affinity DataIC50: 1.53E+3nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355096(CHEMBL1835319)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355110(CHEMBL1835208)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355112(CHEMBL1835211)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355105(CHEMBL1835401)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355104(CHEMBL1835400)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355101(CHEMBL1835324)
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355094(CHEMBL1835317)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355108(CHEMBL1835404)
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM160849(US9045524, 123)
Affinity DataIC50: 3.33E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM160841(US9045524, 111)
Affinity DataIC50: 3.33E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM160786(US9045524, 53 | US10167313, Compound 53)
Affinity DataIC50: 3.33E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of caspase 2 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355102(CHEMBL1835325)
Affinity DataIC50: 5.53E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10295(N-(1,2,3,4-Tetrahydro-1,3,4-trioxoisoquinolin-7-yl...)
Affinity DataIC50: 5.67E+3nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355103(CHEMBL1835399)
Affinity DataIC50: 6.67E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355107(CHEMBL1835403)
Affinity DataIC50: 7.47E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Caspase 2More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of caspase-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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