Compile Data Set for Download or QSAR
Report error Found 5915 of ic50 data for polymerid = 1234,1262,1264,50001013,50002948
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50221967((2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-((S)-...)
Affinity DataIC50: 0.0120nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50612314(CHEMBL5279548)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM205995(US9255098, Ex. 1 | US9255098, Ex. 4)
Affinity DataIC50: 0.0500nMT: 2°CAssay Description:Gly-Pro-7-amido-4-methylcoumarin can be hydrolyzed by dipeptidyl peptidase IV (DPP-IV) at room temperature, to generate 7-amido-4-methyl coumarin, wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Pig)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50437403(CHEMBL2408771)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of porcine DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50221977((2S,3S)-2-amino-3-(4'-fluorobiphenyl-4-yl)-1-((S)-...)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM205995(US9255098, Ex. 1 | US9255098, Ex. 4)
Affinity DataIC50: 0.0800nMT: 2°CAssay Description:Gly-Pro-7-amido-4-methylcoumarin can be hydrolyzed by dipeptidyl peptidase IV (DPP-IV) at room temperature, to generate 7-amido-4-methyl coumarin, wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM408611(US10358449, Compound I-3)
Affinity DataIC50: 0.0800nMAssay Description:DPP-IV could hydrolyze Gly-Pro-Aminoluciferin at room temperature to generate Aminoluciferin, which could produce glow type luminescent signals in a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50611802(CHEMBL5269668)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-7-amido-4-methylcoumarin as substrate incubated for 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50: 0.100nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM205996(US9255098, Ex. 2 | US9255098, Ex. 5)
Affinity DataIC50: 0.100nMT: 2°CAssay Description:Gly-Pro-7-amido-4-methylcoumarin can be hydrolyzed by dipeptidyl peptidase IV (DPP-IV) at room temperature, to generate 7-amido-4-methyl coumarin, wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50151798([6-(2,4-Dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory concentration against Dipeptidyl peptidase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50050513(Ketopyrrolidine derivative | (R)-1-((S)-2-amino-3-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human C-terminal step-tagged DPP4 expressed using baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of dipeptidyl peptidase 4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article

TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50516930(CHEMBL4448186 | US20240115577, Compound 20)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Mouse)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of mouse DPP-4 using Gly-Pro-AMC as substrate measured after 5 mins by CF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50170939(CHEMBL3806052)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166319(4-[(3S,5S)-5-((S)-2-Cyano-pyrrolidine-1-carbonyl)-...)
Affinity DataIC50: 0.130nMAssay Description:Inhibitory concentration against human dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166318((S)-1-[(2S,4S)-4-(3-Chloro-4-cyano-phenylamino)-py...)
Affinity DataIC50: 0.130nMAssay Description:Inhibitory concentration against human dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166319(4-[(3S,5S)-5-((S)-2-Cyano-pyrrolidine-1-carbonyl)-...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Rat)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166318((S)-1-[(2S,4S)-4-(3-Chloro-4-cyano-phenylamino)-py...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of DPP4 in rat plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50607268(CHEMBL5220657)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate incubated for 30 mins by fluorescence based enzyme immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50607267(CHEMBL5220613)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate incubated for 30 mins by fluorescence based enzyme immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50170919(CHEMBL3805966)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM205996(US9255098, Ex. 2 | US9255098, Ex. 5)
Affinity DataIC50: 0.150nMT: 2°CAssay Description:Gly-Pro-7-amido-4-methylcoumarin can be hydrolyzed by dipeptidyl peptidase IV (DPP-IV) at room temperature, to generate 7-amido-4-methyl coumarin, wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Rat)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166318((S)-1-[(2S,4S)-4-(3-Chloro-4-cyano-phenylamino)-py...)
Affinity DataIC50: 0.150nMAssay Description:Inhibitory concentration against rat dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166318((S)-1-[(2S,4S)-4-(3-Chloro-4-cyano-phenylamino)-py...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50607263(CHEMBL5220594)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate incubated for 30 mins by fluorescence based enzyme immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM136294(US8853212, DDP-4 Inhibitor 10)
Affinity DataIC50: 0.170nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Rat)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166308((S)-1-[(2S,4S)-4-(4-Nitro-phenylamino)-pyrrolidine...)
Affinity DataIC50: 0.170nMAssay Description:Inhibitory concentration against rat dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Rat)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166319(4-[(3S,5S)-5-((S)-2-Cyano-pyrrolidine-1-carbonyl)-...)
Affinity DataIC50: 0.170nMAssay Description:Inhibitory concentration against rat dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Rat)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166319(4-[(3S,5S)-5-((S)-2-Cyano-pyrrolidine-1-carbonyl)-...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of DPP4 in rat plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166308((S)-1-[(2S,4S)-4-(4-Nitro-phenylamino)-pyrrolidine...)
Affinity DataIC50: 0.180nMAssay Description:Inhibitory concentration against human dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50371255(CHEMBL1203953)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50516916(CHEMBL4465482)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM479311(US10894794, Comp. Code No. GLP-142)
Affinity DataIC50: 0.180nMAssay Description:itagliptin phosphate monohydrate and the different tested compounds were dissolved in dimethyl sulphoxide (DMSO) and diluted with tris buffer (pH 8.0...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Rat)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50391561(CHEMBL2147704)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of DPP4 in rat plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50166320((S)-1-[(2S,4S)-4-(4-Cyano-phenylamino)-pyrrolidine...)
Affinity DataIC50: 0.190nMAssay Description:Inhibitory concentration against human dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Rat)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50391559(CHEMBL2147703)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of DPP4 in rat plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM11588(1c-meta-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Affinity DataIC50: 0.200nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM11589(1c-para-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Affinity DataIC50: 0.200nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM205997(US9255098, Ex. 3)
Affinity DataIC50: 0.200nMT: 2°CAssay Description:Gly-Pro-7-amido-4-methylcoumarin can be hydrolyzed by dipeptidyl peptidase IV (DPP-IV) at room temperature, to generate 7-amido-4-methyl coumarin, wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM142088(US8933056, Ala-boroPro Thioxamide | US11096924, DA...)
Affinity DataIC50: 0.200nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.200nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50391561(CHEMBL2147704)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of DPP4 in human plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50374938(CHEMBL402163)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant DPP4 expressed in insect cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM408607(US10358449, Compound I-1)
Affinity DataIC50: 0.210nMAssay Description:DPP-IV could hydrolyze Gly-Pro-Aminoluciferin at room temperature to generate Aminoluciferin, which could produce glow type luminescent signals in a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Displayed 1 to 50 (of 5915 total ) | Next | Last >>
Jump to: