Compile Data Set for Download or QSAR
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TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human UGT1A1 using bilirubin as substrate preincubated for 5 mins followed by substrate addition and measured after 40 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant UGT1A1 using bilirubin as substrate incubated for 40 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 600nMAssay Description:Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 600nMAssay Description:Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate incubated for 40 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 792nMAssay Description:KCI838 was incubated at seven increasing concentrations with human UGT1A1-expressed Supersomes (0.25 mg/mL), alamethicin (25 μg/mL) and UDPGA (5...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 970nMAssay Description:Induction of UGT1A1 (unknown origin) assessed as increase in intracellular acidic autophagy vesicles formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50599144(CHEMBL5179012)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 using bilirubin as substrate incubated for 40 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50460863(CHEMBL4227228)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human UGT1A1 expressed in baculovirus infected insect cells using bilirubin as substrate measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50576021(CHEMBL4573938)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628109(CHEMBL5437552)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50553286(CHEMBL4794465)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50600733(CHEMBL5182534)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50088504(CHEBI:45409 | A-84538 | ABBOTT-84538 | Norvir | Ri...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50599144(CHEMBL5179012)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate incubated for 40 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant human UGT1A1 using bilirubin as substrate preincubated for 5 mins followed by substrate addition and measured after 40 mins...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50088504(CHEBI:45409 | A-84538 | ABBOTT-84538 | Norvir | Ri...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of UGT1A1 in rat liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50101979(2,6-dihydroxyanthracene-9,10-dione | anthraflavin ...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM372346(US10245275, Example 2b | Method A: (R)-4-((1R,3aS,...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of UGT1A1(unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50101979(2,6-dihydroxyanthracene-9,10-dione | anthraflavin ...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataIC50: 4.10E+3nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of recombinant rat UGT1A1 using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured after 40 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009001(CHEMBL8260 | Baicalein | 5,6,7-Trihydroxyflavone |...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50301375(L-thyroxine | 3,3',5,5'-tetraiodo-L-thyronine | 3,...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50301375(L-thyroxine | 3,3',5,5'-tetraiodo-L-thyronine | 3,...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50550263(CHEMBL4748750)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009001(CHEMBL8260 | Baicalein | 5,6,7-Trihydroxyflavone |...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23420(CHEMBL8145 | US8552057, 7 | 7-hydroxy-3-(4-hydroxy...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM25759([3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-met...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of recombinant rat UGT1A1 using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured after 40 m...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM85507(NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of UGT1A1 in rat liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50001839(CHEMBL428647 | taxol | PACLITAXEL)
Affinity DataIC50: 2.00E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50460861(CHEMBL4229237)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of UGT1A1 in human liver microsomes assessed as decrease in estradiol-3 glucuronidationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50187243(ethinyloestradiol | 17alpha-ethynylestra-1,3,5(10)...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM21363(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)
Affinity DataIC50: 2.60E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM25759([3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-met...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM660588(US11938127, Compound KCI838)
Affinity DataIC50: 3.59E+4nMAssay Description:KCI838 was incubated at seven increasing concentrations with human UGT1A1-expressed Supersomes (0.25 mg/mL), alamethicin (25 μg/mL) and UDPGA (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 3.80E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM11021((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol |...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM8885(Testosterone, 1 | (1S,2R,10R,11S,14S,15S)-14-hydro...)
Affinity DataIC50: 4.30E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50187243(ethinyloestradiol | 17alpha-ethynylestra-1,3,5(10)...)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM234401(Oleandomycin)
Affinity DataIC50: 4.40E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM11021((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol |...)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50: 4.80E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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