Compile Data Set for Download or QSAR
Report error Found 428 of ic50 data for complexid = 50000896,50009013
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50: 0.00300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 0.00400nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataIC50: 0.00400nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 0.00900nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50001707(Tylox | Oxycet | Combunox | Codoxy | Percocet | 10...)
Affinity DataIC50: 0.0130nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225845(CHEMBL293967)
Affinity DataIC50: 0.0150nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225204(CHEMBL606711)
Affinity DataIC50: 0.0200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.0270nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.0500nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50: 0.0800nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225211(CHEMBL606767)
Affinity DataIC50: 0.0850nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001707(Tylox | Oxycet | Combunox | Codoxy | Percocet | 10...)
Affinity DataIC50: 0.150nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50326670(17-methoxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyc...)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225206(CHEMBL606643)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225213(CHEMBL606820)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50027473(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [3H]nalotrexone from rat-brain Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50013184(CHEMBL343066 | 1H-Indole-2-carboxylic acid [5-(2-f...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [3H]dihydromorphine (DHM) from rat brain Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataIC50: 0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225214(CHEMBL606769)
Affinity DataIC50: 0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225848(CHEMBL53563)
Affinity DataIC50: 0.300nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 0.360nMAssay Description:Compound was tested for antagonistic activity against opioid receptor in mouse vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50354578(BUPRENORPHINE | US9315514, Buprenorphine | US10752...)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50224336(CHEMBL1744168)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224339(CHEMBL1744167)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50354578(BUPRENORPHINE | US9315514, Buprenorphine | US10752...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50013209(CHEMBL140365 | 4-Chloro-N-[5-(2-fluoro-phenyl)-1-m...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]dihydromorphine (DHM) from rat brain Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225212(CHEMBL606707)
Affinity DataIC50: 0.5nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225232(CHEMBL606768)
Affinity DataIC50: 0.5nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [3H]naloxone binding to opioid receptor in presence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224323(CHEMBL1794881)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224340(CHEMBL147150)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224315(CHEMBL2304164)
Affinity DataIC50: 0.600nMAssay Description:Displacement [3H]naloxone from rat-brain Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021347(N-(3-Methyl-1-phenethyl-piperidin-4-yl)-N-phenyl-p...)
Affinity DataIC50: 0.600nMAssay Description:Displacement [3H]naloxone from rat-brain Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of [3H]naloxone binding to opioid receptor in presence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225849(CHEMBL301654)
Affinity DataIC50: 0.640nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224323(CHEMBL1794881)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225204(CHEMBL606711)
Affinity DataIC50: 0.700nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.75nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225208(CHEMBL606819)
Affinity DataIC50: 0.75nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225207(CHEMBL553032)
Affinity DataIC50: 0.800nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224341(CHEMBL1744169)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50223629(CHEMBL351642)
Affinity DataIC50: 0.840nMAssay Description:Binding affinity to opioid receptors by the displacement of [3H]fentanyl in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225211(CHEMBL606767)
Affinity DataIC50: 0.850nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224322(CHEMBL1744170)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224341(CHEMBL1744169)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224320(CHEMBL1744186)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50247803(Beta-Funeltrexamine | beta-funaltrexamine | methyl...)
Affinity DataIC50: 1nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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