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Report error Found 532 of ic50 data for complexid = 50000800,50008918,50012345
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 0.280nMAssay Description:Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50020220(CHEMBL38428 | 3-Dipropylamino-chroman-8-ol)
Affinity DataIC50: 0.320nMAssay Description:In vitro affinity to dopamine receptor using [3H]NPAD as radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidolMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225369(CHEMBL295712)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataIC50: 0.920nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataIC50: 1.10nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpirideMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225774(CHEMBL161122)
Affinity DataIC50: 1.5nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017543(9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of [3H]apomorphine binding to dopamine receptor of rat corpus striatumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM81195(cid_3153 | 6-Amino-5,6,7,8-tetrahydro-naphthalene-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpirideMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026051(A 38120 | CHEMBL62429 | 3,5-Dichloro-N-(1-ethyl-py...)
Affinity DataIC50: 1.80nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225247(CHEMBL44558)
Affinity DataIC50: 2nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224790(CHEMBL333794)
Affinity DataIC50: 2nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366495(CHEMBL1255588 | (+)butaclamol)
Affinity DataIC50: 2nMAssay Description:Concentration inhibiting the specific binding of [3H]spiroperidol by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataIC50: 2.10nMAssay Description:Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpirideMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50224791(RU-29717 | CHEMBL333795)
Affinity DataIC50: 2.20nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026044(CHEMBL161668 | A 37850 | 3-Bromo-5-ethyl-N-(1-ethy...)
Affinity DataIC50: 2.30nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021224((+) (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]...)
Affinity DataIC50: 2.30nMAssay Description:Effect on synaptosomal uptake inhibition of Dopamine receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225894(CHEMBL63789)
Affinity DataIC50: 2.30nMAssay Description:Affinity for Dopamine receptors in the rat striatum using [3H]spiroperidol displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026553((-)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against [3H]NPA binding (0.45) to dopamine receptor in striata of female wistar ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026553((-)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against [3H]NPA binding (0.45) to dopamine receptor in striata of female wistar ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50007422((R)-10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225762(CHEMBL161973)
Affinity DataIC50: 2.60nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataIC50: 2.60nMAssay Description:In vitro affinity to dopamine receptor using [3H]NPAD as radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50327157((R)-methyl 2-(3,4-dichlorophenyl)-2-((R)-piperidin...)
Affinity DataIC50: 2.70nMAssay Description:Potency of inhibiting 10 pM [125I]-RTI-55 binding to dopamine receptor in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026958((cis) 2-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...)
Affinity DataIC50: 2.80nMAssay Description:Effect on synaptosomal uptake inhibition of Dopamine receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225771(CHEMBL350287)
Affinity DataIC50: 3nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM81195(cid_3153 | 6-Amino-5,6,7,8-tetrahydro-naphthalene-...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22872(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataIC50: 3nMAssay Description:Ability to displace [3H]haloperidol from rat striatal membranes, in order to measure its intrinsic affinity for the dopamine (DA) receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM79172(Fluphenthixol | SMR000875208 | cid_10140115 | 2-[4...)
Affinity DataIC50: 3nMAssay Description:Ability to displace [3H]haloperidol from rat striatal membranes, in order to measure its intrinsic affinity for the dopamine (DA) receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017543(9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10...)
Affinity DataIC50: 3.10nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM81195(cid_3153 | 6-Amino-5,6,7,8-tetrahydro-naphthalene-...)
Affinity DataIC50: 3.10nMAssay Description:Evaluated for the inhibition of binding of [3H]DA (dopamine) to dopamine receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017543(9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10...)
Affinity DataIC50: 3.10nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225267(CHEMBL48264)
Affinity DataIC50: 3.20nMAssay Description:Concentration inhibiting the specific binding of [3H]naloxone by 50% in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225241(CHEMBL42242)
Affinity DataIC50: 3.30nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026553((-)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against [3H]NPA binding (0.45) to dopamine receptors in striata of female wistar ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017543(9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of [3H]dopamine binding to dopamine receptor of rat corpus striatumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021224((+) (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]...)
Affinity DataIC50: 4.40nMAssay Description:Effect on synaptosomal uptake inhibition of Dopamine receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026059(CHEMBL23403 | A 37843 | 3,5-Dichloro-N-(1-ethyl-py...)
Affinity DataIC50: 4.70nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225266(CHEMBL555325)
Affinity DataIC50: 4.80nMAssay Description:Concentration inhibiting the specific binding of [3H]naloxone by 50% in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225770(CHEMBL345223)
Affinity DataIC50: 5nMAssay Description:Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 5nMAssay Description:The IC50 value was reported as apparent, since [3H]NCA was purported to be irreversible. Result indicates the mean of two separate experiments, each ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50007422((R)-10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50327157((R)-methyl 2-(3,4-dichlorophenyl)-2-((R)-piperidin...)
Affinity DataIC50: 5.30nMAssay Description:Potency of inhibiting [3H]WIN-35428 binding to dopamine receptor in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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