Compile Data Set for Download or QSAR
Report error Found 31 of ic50 data for complexid = 50000449
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 13nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585510(CHEMBL5076068)
Affinity DataIC50: 16nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585511(CHEMBL5077126)
Affinity DataIC50: 16nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585509(CHEMBL5085176)
Affinity DataIC50: 20nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50: 20nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50585512(CHEMBL5075223)
Affinity DataIC50: 20nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 21nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in human whole blood assessed as inhibition of IL-6-induced STAT-1 phosphorylation preincubated for 45 mins followed by ...More data for this Ligand-Target Pair
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LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50: 32nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585508(CHEMBL5079248)
Affinity DataIC50: 32nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585513(CHEMBL5087255)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585507(CHEMBL5078141)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585518(CHEMBL5094089)
Affinity DataIC50: 63nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585506(CHEMBL5074310)
Affinity DataIC50: 63nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 75nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in human whole blood assessed as inhibition of IL-6-induced STAT-1 phosphorylation preincubated for 45 mins followed by ...More data for this Ligand-Target Pair
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LigandPNGBDBM50585517(CHEMBL5076101)
Affinity DataIC50: 79nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585500(CHEMBL5077653)
Affinity DataIC50: 100nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585502(CHEMBL5082928)
Affinity DataIC50: 126nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50602437(CHEMBL5172397 | US11919896, Compound 1-13)
Affinity DataIC50: 126nMAssay Description:Inhibition of JAK1/JAK2/TYK2 signalling in human whole blood assessed as inhibition of IL-6 stimulated STAT1 phosphorylation in CD4+ lymphocytes prei...More data for this Ligand-Target Pair
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LigandPNGBDBM50585504(CHEMBL5084340)
Affinity DataIC50: 158nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50585503(CHEMBL5084913)
Affinity DataIC50: 158nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 163nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in CD14+ human whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincubated for 45 mins followed...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM305821(US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...)
Affinity DataIC50: 201nMAssay Description:Inhibition of TYK2/JAK1/JAK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation prein...More data for this Ligand-Target Pair
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LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 298nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in human whole blood assessed as inhibition of IL-6-induced STAT-1 phosphorylation preincubated for 45 mins followed by ...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 407nMAssay Description:Inhibition of JAK1/JAK2/TYK2 signalling in human whole blood assessed as inhibition of IL-6 stimulated STAT1 phosphorylation in CD4+ lymphocytes prei...More data for this Ligand-Target Pair
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LigandPNGBDBM305821(US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...)
Affinity DataIC50: 566nMAssay Description:Inhibition of TYK2/JAK1/JAK2 signaling pathway in human whole blood spiked with CD3 +ve cells assessed as reduction in IL-6 induced STAT1 phosphoryla...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50021657(CHEMBL3297839)
Affinity DataIC50: 918nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in human whole blood assessed as inhibition of IL-6-induced STAT-1 phosphorylation preincubated for 45 mins followed by ...More data for this Ligand-Target Pair
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LigandPNGBDBM50021655(VRT-831509 | VX-509 | DECERNOTINIB | US10112907, E...)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in human whole blood assessed as inhibition of IL-6-induced STAT-1 phosphorylation preincubated for 45 mins followed by ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM305821(US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...)
Affinity DataIC50: 4.37E+3nMAssay Description:Inhibition of TYK2/JAK1/JAK2 signaling pathway in human whole blood spiked with CD3 +ve cells assessed as reduction in IL-6 induced STAT3 phosphoryla...More data for this Ligand-Target Pair
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PubMed