Compile Data Set for Download or QSAR
Report error Found 93 of ic50 data for complexid = 347,50000068
LigandPNGBDBM50290077(N-[2-(4-Chloro-phenyl)-imidazo[1,2-a]pyridin-3-ylm...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of [3H]flumazenil binding to recombinant GABA-A receptor alpha-1-beta-2-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50290077(N-[2-(4-Chloro-phenyl)-imidazo[1,2-a]pyridin-3-ylm...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of [3H]flumazenil binding to recombinant GABA-A receptor alpha-1-beta-2-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50483961(CHEMBL1795561)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50483959(CHEMBL1795560)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482687(CHEMBL426916)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50483958(CHEMBL1795348)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50537125(CHEMBL1851667)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA(A) receptor expressed in human tsA201 cells assessed as inhibition of GABA-induced membrane pote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482692(CHEMBL390326)
Affinity DataIC50: 20nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50378769(CHEMBL1204074)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA(A) receptor expressed in human tsA201 cells assessed as inhibition of GABA-induced membrane pote...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378769(CHEMBL1204074)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238234(US9388210, 14a | US9388210, 6a)
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238243(US9388210, 16a)
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482694(CHEMBL229535)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482688(CHEMBL387958)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50215531(2-chloro-alpha-[[(4-chlorophenyl)amino]methylene]-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50483960(CHEMBL1795562)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482691(CHEMBL556727)
Affinity DataIC50: 45nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | ZPM | N,N-dimethyl-2-[6-methy...)
Affinity DataIC50: 46nMAssay Description:Inhibition of [3H]flumazenil binding to recombinant GABA-A receptor alpha-1-beta-2-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482690(CHEMBL229374)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238245(US9388210, 17a)
Affinity DataIC50: 53nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238238(US9388210, 15a | US9388210, 13a)
Affinity DataIC50: 56nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50520683(CHEMBL4476621)
Affinity DataIC50: 75nMAssay Description:Displacement of [3H]muscimol from recombinant human GABAalpha1beta2gamma2 measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50208721(CHEMBL1204123 | CHEMBL223324 | 4-(biphenyl-3-yl)-5...)
Affinity DataIC50: 78nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482696(CHEMBL229201)
Affinity DataIC50: 79nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238234(US9388210, 14a | US9388210, 6a)
Affinity DataIC50: 128nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50378770(CHEMBL1202335)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482686(CHEMBL227018)
Affinity DataIC50: 158nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50378760(CHEMBL1202340)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50493007(CHEMBL2420450)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50378763(CHEMBL1204077)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378763(CHEMBL1204077)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378763(CHEMBL1204077)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA(A) receptor expressed in human tsA201 cells assessed as inhibition of GABA-induced membrane pote...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50493007(CHEMBL2420450)
Affinity DataIC50: 214nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50001572(4-(6-imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)b...)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA(A) receptor expressed in human tsA201 cells assessed as inhibition of GABA-induced membrane pote...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001572(4-(6-imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)b...)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001572(4-(6-imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)b...)
Affinity DataIC50: 349nMAssay Description:Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50482689(CHEMBL388639)
Affinity DataIC50: 398nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238238(US9388210, 15a | US9388210, 13a)
Affinity DataIC50: 474nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50378771(CHEMBL1204073)
Affinity DataIC50: 480nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238235(US9388210, 14b | US9388210, 6b)
Affinity DataIC50: 501nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238244(US9388210, 16b)
Affinity DataIC50: 544nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238246(US9388210, 17b)
Affinity DataIC50: 605nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238236(US9388210, 6c)
Affinity DataIC50: 629nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50493006(CHEMBL2420454)
Affinity DataIC50: 690nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50493006(CHEMBL2420454)
Affinity DataIC50: 692nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM238248(US9388210, 5b)
Affinity DataIC50: 770nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50493003(CHEMBL2420455)
Affinity DataIC50: 780nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50378772(CHEMBL1204072)
Affinity DataIC50: 790nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50588336(CHEMBL5186739)
Affinity DataIC50: 794nMAssay Description:Antagonist activity at human alpha1beta2gamma2 GABAA receptor expressed in HEK by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50493003(CHEMBL2420455)
Affinity DataIC50: 794nMAssay Description:Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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