Compile Data Set for Download or QSAR
Report error Found 291 Enz. Inhib. hit(s) with BLAST sequence identity > 85%
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50038162(5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione | CH...)
Affinity DataEC50:  400nMAssay Description:Compound was evaluated for in vitro inhibition of [3H]-GABA release at NMDA receptor.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004938(CHEMBL300949 | 3-Carboxymethylsulfanyl-4,6-dichlor...)
Affinity DataEC50:  1.40E+5nMAssay Description:Compound was evaluated for in vitro inhibition of cortical slice at NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50038178((4R)-4-aminoisoxazolidin-3-one | cycloserine | (+)...)
Affinity DataEC50:  1.81E+4nMAssay Description:Compound was evaluated for in vitro inhibition of [3H]TCP at NMDA receptor.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50503147(CHEMBL4435232)
Affinity DataEC50:  6.60E+3nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50503144(CHEBI:35420 | CHEMBL1179605)
Affinity DataEC50:  8.30E+4nMAssay Description:Positive allosteric modulation of EGFP-fused human GluN2C receptor expressed in HEK293T cells assessed as increase in glycine-induced channel current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  2.70E+3nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50503152(CHEMBL4452216)
Affinity DataEC50:  3.70E+4nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50007007(CHEMBL3237281)
Affinity DataEC50:  1.30E+4nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50611444(CHEMBL5273123)
Affinity DataEC50:  1.90E+3nMAssay Description:Positive allosteric modulator activity at GluN2C NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091629(5-{3-[4-(4-Fluoro-benzyl)-4-hydroxy-piperidin-1-yl...)
Affinity DataIC50: 24nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50: 34nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50280813(5-[(1S,2S)-1-Hydroxy-2-(4-phenyl-piperidin-1-yl)-p...)
Affinity DataIC50: 40nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
In DepthDetails Article

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007677(4-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-p...)
Affinity DataIC50: 55nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
In DepthDetails Article

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091649(6-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1-meth...)
Affinity DataIC50: 98nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2B NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078498(4-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-phenol...)
Affinity DataIC50: 100nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50280812(5-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-p...)
Affinity DataIC50: 111nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
In DepthDetails Article

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50038162(5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione | CH...)
Affinity DataIC50: 170nMAssay Description:Compound was evaluated for in vitro inhibition of [3H]L-689,560 at NMDA receptor.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078480(4-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-phenol ...)
Affinity DataIC50: 170nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440067(CHEMBL2426073 | CHEMBL2426072)
Affinity DataIC50: 200nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440060(CHEMBL2426081)
Affinity DataIC50: 220nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50280811(5-[(1R,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-p...)
Affinity DataIC50: 231nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
In DepthDetails Article

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007674((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)
Affinity DataIC50: 263nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
In DepthDetails Article

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50038162(5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione | CH...)
Affinity DataIC50: 400nMAssay Description:Compound was evaluated for in vitro inhibition of cortical slice release at NMDA receptor.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440084(CHEMBL2426093)
Affinity DataIC50: 560nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50280810(5-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-1-hydrox...)
Affinity DataIC50: 600nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
In DepthDetails Article

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440065(CHEMBL2426075)
Affinity DataIC50: 600nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM83449(cid_9795678 | PHENCYCLIDINE | SMR001338811 | Phenc...)
Affinity DataIC50: 600nMAssay Description:Inhibition activity against binding of phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091625(5-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-1H-indo...)
Affinity DataIC50: 630nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440085(CHEMBL2426092)
Affinity DataIC50: 710nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440057(CHEMBL2426097)
Affinity DataIC50: 770nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440072(CHEMBL2426067)
Affinity DataIC50: 780nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440074(CHEMBL2426065)
Affinity DataIC50: 780nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440075(CHEMBL2425979)
Affinity DataIC50: 790nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50436102(CHEMBL2397256 | US10273214, Example 1180-26)
Affinity DataIC50: 800nMAssay Description:The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017028(CHEMBL442106 | 8-(2-Methoxy-phenyl)-1,2,3,4-tetrah...)
Affinity DataIC50: 900nMAssay Description:Inhibition of [3H]1-[1-(2-thienyl) piperidine ([3H]TCP) binding to PCP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440091(CHEMBL2426086)
Affinity DataIC50: 900nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440077(CHEMBL2425977)
Affinity DataIC50: 910nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440081(CHEMBL2426096)
Affinity DataIC50: 950nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50242449(conantokin-G | CHEMBL525025)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat NMDA NR2C receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079387(CHEMBL28564 | 1-(4-Chloro-phenyl)-2-[4-(4-fluoro-b...)
Affinity DataIC50: 1.00E+3nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
In DepthDetails Article

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440058(CHEMBL2426100)
Affinity DataIC50: 1.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440067(CHEMBL2426073 | CHEMBL2426072)
Affinity DataIC50: 1.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50436082(CHEMBL2397103 | US10273214, Example 1391)
Affinity DataIC50: 1.00E+3nMAssay Description:The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50436101(CHEMBL2397257 | US10273214, Example 1180-27)
Affinity DataIC50: 1.00E+3nMAssay Description:The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440052(CHEMBL2426105)
Affinity DataIC50: 1.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440073(CHEMBL2426066)
Affinity DataIC50: 1.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50436090(CHEMBL2397119 | US10273214, Example 1180-31)
Affinity DataIC50: 1.20E+3nMAssay Description:The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440076(CHEMBL2425978)
Affinity DataIC50: 1.40E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50009093(CHEMBL277411 | 6-Chloro-3-ethoxycarbonylmethyl-1H-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Compound was evaluated for in vitro inhibition of oocytes at NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440063(CHEMBL2426077)
Affinity DataIC50: 1.70E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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