Compile Data Set for Download or QSAR
Report error Found 104 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]'
LigandPNGBDBM285634(US10077269, Example 104 | 3-(4-chloro-3,5-difluoro...)
Affinity DataIC50: 1.59nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285538(US10077269, Example 11 | N-cyclopropyl-3-(3,4-di-c...)
Affinity DataIC50: 1.60nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285534(US10077269, Example 7 | 3-(4-Chloro-3-fluorophenyl...)
Affinity DataIC50: 1.89nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285572(US10077269, Example 45 | 3-(4-chloro-3-fluoropheny...)
Affinity DataIC50: 1.97nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285598(US10077269, Example 71 | 3-(3-chloro-4-methylpheny...)
Affinity DataIC50: 2.82nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285537(US10077269, Example 10 | 3-(4-chloro-3-fluoro-phen...)
Affinity DataIC50: 3.80nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285574(US10077269, Example 47 | azetidin-1-yl[3-(4-chloro...)
Affinity DataIC50: 3.90nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285571(US10077269, Example 44 | 3-(4-chloro-3-fluoropheny...)
Affinity DataIC50: 3.92nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285540(US10077269, Example 13 | azetidin-1-yl[3-(4-chloro...)
Affinity DataIC50: 4.63nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285556(US10077269, Example 29 | 3-(4-chloro-3-fluoropheny...)
Affinity DataIC50: 5.05nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285612(US10077269, Example 82 | 3-(4-chloro-3-fluoropheny...)
Affinity DataIC50: 5.14nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285613(US10077269, Example 83 | azetidin-1-yl[3-(3,4-dich...)
Affinity DataIC50: 5.39nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285603(US10077269, Example 76 | azetidin-1-yl{3-[2-(diflu...)
Affinity DataIC50: 5.43nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285547(US10077269, Example 20 | 4-[2-(azetidin-1-ylcarbon...)
Affinity DataIC50: 5.74nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285602(US10077269, Example 75 | N-cyclopropyl-3-[2-(diflu...)
Affinity DataIC50: 5.99nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285563(US10077269, Example 36 | 3-(3-chlorophenyl)-N-cycl...)
Affinity DataIC50: 6.99nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285616(US10077269, Example 86 | azetidin-1-yl[3-(2,2-difl...)
Affinity DataIC50: 7.72nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285614(US10077269, Example 84 | azetidin-1-yl[3-(3-chloro...)
Affinity DataIC50: 7.84nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285568(US10077269, Example 41 | N-cyclopropyl-3-(3-fluoro...)
Affinity DataIC50: 8.05nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285611(US10077269, Example 81 | 3-(4-chloro-3-fluoropheny...)
Affinity DataIC50: 9.34nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM285536(US10077269, Example 9 | 3-(4-Chloro-2,5-difluoroph...)
Affinity DataIC50: 10.5nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285573(US10077269, Example 46 | 3-(4-chlorophenyl)-N-[(1R...)
Affinity DataIC50: 12.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285576(US10077269, Example 49 | azetidin-1-yl[3-(3-chloro...)
Affinity DataIC50: 13.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285546(US10077269, Example 19 | 3-(4-cyano-5-fluoro-2-met...)
Affinity DataIC50: 13.6nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285529(US10077269, Example 2 | 3-(4-Chlorophenyl)-N-cyclo...)
Affinity DataIC50: 17.7nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285590(US10077269, Example 63 | 1-{3-[2-(azetidin-1-ylcar...)
Affinity DataIC50: 17.7nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285551(US10077269, Example 24 | 4-[2-(azetidin-1-ylcarbon...)
Affinity DataIC50: 19.1nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285622(US10077269, Example 92 | 3-(4-cyano-2,5-difluoroph...)
Affinity DataIC50: 21nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285627(US10077269, Example 97 | 3-(4-chloro-5-fluoro-2-me...)
Affinity DataIC50: 23.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285591(US10077269, Example 64 | azetidin-1-yl[3-(5-chloro...)
Affinity DataIC50: 24.2nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285566(US10077269, Example 39 | 3-(1,3-benzoxazol-5-yl)-N...)
Affinity DataIC50: 26.5nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285530(US10077269, Example 3 | Azetidin-1-yl[3-(3,5-diflu...)
Affinity DataIC50: 29.1nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285550(US10077269, Example 23 | 4-[2-(azetidin-1-ylcarbon...)
Affinity DataIC50: 30.5nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285597(US10077269, Example 70 | 3-(4-chloro-2-methylpheny...)
Affinity DataIC50: 31nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285555(US10077269, Example 28 | 3-(3,5-dichlorophenyl)-N-...)
Affinity DataIC50: 31.7nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285626(US10077269, Example 96 | 3-(4-chloro-2,5-difluoro-...)
Affinity DataIC50: 33.2nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285595(US10077269, Example 68 | 3-(4-chloro-2-fluoropheny...)
Affinity DataIC50: 35.4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285528(US10077269, Example 1 | Azetidin-1-yl[3-(4-chlorop...)
Affinity DataIC50: 35.5nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285539(US10077269, Example 12 | 3-(4-chloro-2-methyl-phen...)
Affinity DataIC50: 35.8nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285629(US10077269, Example 99 | 3-(4-cyano-5-fluoro-2-met...)
Affinity DataIC50: 36.2nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285621(US10077269, Example 91 | azetidin-1-yl[3-(4-chloro...)
Affinity DataIC50: 36.9nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285579(US10077269, Example 52 | azetidin-1-yl[3-(4-chloro...)
Affinity DataIC50: 37.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285618(US10077269, Example 88 | 3-(1,3-benzoxazol-6-yl)-N...)
Affinity DataIC50: 39.2nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285593(US10077269, Example 66 | azetidin-1-yl[3-(3-chloro...)
Affinity DataIC50: 41nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285535(US10077269, Example 8 | Azetidin-1-yl[3-(pyrazolo[...)
Affinity DataIC50: 41.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285578(US10077269, Example 51 | azetidin-1-yl[3-(4-chloro...)
Affinity DataIC50: 42.9nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285583(US10077269, Example 56 | azetidin-1-yl[3-(4-chloro...)
Affinity DataIC50: 43.1nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285585(US10077269, Example 58 | 3-(4-chlorophenyl)-N-(5-m...)
Affinity DataIC50: 43.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285620(US10077269, Example 90 | 3-(4-cyano-3-fluorophenyl...)
Affinity DataIC50: 43.7nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM285562(US10077269, Example 35 | 3-(3-chloro-5-fluoropheny...)
Affinity DataIC50: 48nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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