Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with Target = 'cAMP-dependent protein kinase catalytic subunit gamma'
LigandPNGBDBM50587771(CHEMBL5183651)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to PKA (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  154nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKACG (unknown origin) expressed in baculovirus infected Sf9 insect cells...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  148nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKACG (unknown origin) expressed in baculovirus infected Sf9 insect cells...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PKA (unknown origin) after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PKAcg using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50587770(CHEMBL5188493)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50228843(CHEMBL436718)
Affinity DataIC50: 3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6.5nMAssay Description:In vitro inhibition of Protein Kinase AMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human PKAcg using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 10nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 15nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataIC50: 50nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50587769(CHEMBL5181354)
Affinity DataIC50: 159nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50614310(CHEMBL5269663)
Affinity DataIC50: 184nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 250nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 250nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50228839(CHEMBL415414)
Affinity DataIC50: 300nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50: 790nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50228847(CHEMBL407100)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228838(CHEMBL428973)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PKA-mediated phosphorylation of kemptide at 100 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228846(CHEMBL265876)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50358686(CHEMBL1922138)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50614312(CHEMBL5284365)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50614314(CHEMBL5269818)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50597471(CHEMBL5176687)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50228841(CHEMBL351282)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026615(CHEMBL1922045)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50614313(CHEMBL5283378)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50216682(cid_3542 | 1-(5-Isoquinolinesulfonyl)-2-methylpipe...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of human PKAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM15203(Isoquinoline-5-sulfonic acid piperazin-1 ylamide |...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50358469(CHEMBL1922026)
Affinity DataIC50: 6.74E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50206006(7,8-dihydroxy-2H-chromen-2-one | 7,8-dihydroxycoum...)
Affinity DataIC50: 9.33E+3nMAssay Description:Inhibition of PKA (unknown origin) using Kemptide as substrate incubated for [gamma-32P]-ATP incubated for 5 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50525707(CHEMBL4457566)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKAcgamma using [KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK] as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50593027(CHEMBL5186340)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50614307(CHEMBL5278333)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50431132(CHEMBL2332080)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50614311(CHEMBL5267373)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM2581(CHEMBL16958 | 3,13,23-triazahexacyclo[14.7.0.0^{2,...)
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50054426(7-hydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyr...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50587768(CHEMBL5172395)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM2672(6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyr...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50228842(CHEMBL437640)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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