Compile Data Set for Download or QSAR
Report error Found 106 Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 1/2'
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168397(2,4-difluoro-5-(5-isopropyl-6-(5-methyloxazol-2-yl...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168410(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50026679(CHEMBL3335371)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168390(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168398(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168391(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168388(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26028(4-({2-[(3-tert-butylphenyl)(methyl)amino]-1H-1,3-b...)
Affinity DataIC50: 5nMAssay Description:Inhibition of VEGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168393(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168400(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50026673(CHEMBL3335387)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168403(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Affinity DataIC50: 17nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168394(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)
Affinity DataIC50: 18nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168420([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 19nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31088(1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of VEGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168395(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)
Affinity DataIC50: 25nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM381830(US10272087, Compound 13 | US10272087, Compound 2)
Affinity DataIC50: 25.1nMAssay Description:In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168402(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Affinity DataIC50: 27nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127687(CHEMBL3632717)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168399([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 31nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168407(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)
Affinity DataIC50: 35nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168392([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 46nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168406(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-4H-[1,2,4]...)
Affinity DataIC50: 50nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168417([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 62nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50131822(CHEMBL3632719)
Affinity DataIC50: 70nMAssay Description:Inhibition of VEGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168404(2,4-Difluoro-5-(5-isopropyl-6-[1,3,4]oxadiazol-2-y...)
Affinity DataIC50: 91nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 100nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM381829(US10272087, Compound 11 | US10272087, Compound 1)
Affinity DataIC50: 100nMAssay Description:In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475107(CHEMBL179928)
Affinity DataIC50: 170nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475105(CHEMBL189605)
Affinity DataIC50: 200nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475147(CHEMBL185804)
Affinity DataIC50: 210nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475104(CHEMBL362085)
Affinity DataIC50: 240nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475152(CHEMBL188975)
Affinity DataIC50: 240nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 250nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR (789-end) expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by ATP...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475139(CHEMBL187192)
Affinity DataIC50: 250nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475145(CHEMBL187453)
Affinity DataIC50: 250nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM381830(US10272087, Compound 13 | US10272087, Compound 2)
Affinity DataIC50: 251nMAssay Description:In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50468983(CHEMBL4282506)
Affinity DataIC50: 276nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR (789-end) expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by ATP...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475159(CHEMBL189864)
Affinity DataIC50: 300nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475122(CHEMBL188715)
Affinity DataIC50: 350nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475146(CHEMBL189138)
Affinity DataIC50: 350nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475124(CHEMBL188687)
Affinity DataIC50: 360nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM381835(US10272087, Compound 9)
Affinity DataIC50: 398nMAssay Description:In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475109(CHEMBL185679)
Affinity DataIC50: 410nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475121(CHEMBL363735)
Affinity DataIC50: 410nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475154(CHEMBL187967)
Affinity DataIC50: 440nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475108(CHEMBL180882)
Affinity DataIC50: 460nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475131(CHEMBL364656)
Affinity DataIC50: 530nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50475134(CHEMBL181855)
Affinity DataIC50: 530nMAssay Description:Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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