Compile Data Set for Download or QSAR
Report error Found 94 Enz. Inhib. hit(s) with Target = 'Urease subunit alpha'
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50449754(CHEMBL4167553)
Affinity DataIC50: 43nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production preincubated for 1.5 hrs under cell free condition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease subunit alpha/beta/gamma(Bacillus pasteurii)
Wroclaw University of Technology

LigandPNGBDBM24969([(2-{[(benzyloxy)carbonyl]amino}acetamido)methyl](...)
Affinity DataKi:  170nM ΔG°:  -39.3kJ/mole IC50: 1.80E+3nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha [F36L]/beta/gamma(Proteus vulgaris)
Wroclaw University of Technology

LigandPNGBDBM24969([(2-{[(benzyloxy)carbonyl]amino}acetamido)methyl](...)
Affinity DataKi:  450nM ΔG°:  -36.8kJ/mole IC50: 3.10E+3nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221061(7-(4-Acetylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-...)
Affinity DataIC50: 1.22E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221056(7-(4-Acetylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-...)
Affinity DataIC50: 1.29E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173607((Z)-2-((Z)-(Napthalen-1-ylmethylene)hydrazono)thia...)
Affinity DataIC50: 1.73E+3nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221063(7-(4-(3,4,5-Trimethoxy piperazin-1-yl))-1-cyclopro...)
Affinity DataIC50: 2.08E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221066((S)-9-Fluoro-3,7-dihydro-N-hydroxy-3-methyl-10-(4-...)
Affinity DataIC50: 2.20E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221051(7-(4-Acetylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-...)
Affinity DataIC50: 2.22E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221050(N-acetyl ciprofloxacin)
Affinity DataIC50: 2.26E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173602((Z)-2-((Z)-(1-(2-Bromo-4-nitrophenyl)ethylidene)hy...)
Affinity DataIC50: 2.31E+3nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221067((S)-9-Fluoro-3,7-dihydro-N,3-dimethyl-10-(4-methyl...)
Affinity DataIC50: 2.89E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221058(7-(4-(3,4,5-Trimetoxybenzoylpiperazin-1-yl))-1-cyc...)
Affinity DataIC50: 2.92E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532158(CHEMBL4437765)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532155(CHEMBL4473387)
Affinity DataIC50: 4.97E+3nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532153(CHEMBL4441391)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173604((Z)-2-((Z)-(4-Ethoxy-3-methoxybenzoylidine)hydrazo...)
Affinity DataIC50: 5.75E+3nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221053(7-(4-(3,4,5-Trimethoxybenzoylpiperazin-1-yl)-1-cyc...)
Affinity DataIC50: 7.17E+3nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173597((E)-2-((E)-(4-(Benzyloxy)-2-methoxybenzylidene)hyd...)
Affinity DataIC50: 7.30E+3nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173595((E)-2((E)-(3-nitrobenzylidene)hydrazono)thiazolidi...)
Affinity DataIC50: 8.43E+3nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM60584((Z)-2-((Z)-(Napthalen-1-ylmethylene)hydrazono)thia...)
Affinity DataIC50: 8.81E+3nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173590((E)-2-((E)-(3-Chloro-4-hydroxybenzylideno)thiazoli...)
Affinity DataIC50: 9.34E+3nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM181105(3-(3,4,5-Trimethoxybenzoyl)-(4-hydroxycoumarin) (9...)
Affinity DataIC50: 1.13E+4nMT: 2°CAssay Description:Reaction mixtures comprising one unit of urease enzyme (B. pasteurii) solution and 55 uL of buffers containing 100 mMol urea were incubated with 5 uL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM181103(3-Decanoyl-(4-hydroxycoumarin) (5))
Affinity DataIC50: 1.30E+4nMT: 2°CAssay Description:Reaction mixtures comprising one unit of urease enzyme (B. pasteurii) solution and 55 uL of buffers containing 100 mMol urea were incubated with 5 uL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532164(CHEMBL4436232)
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha [F36L]/beta/gamma(Proteus vulgaris)
Wroclaw University of Technology

LigandPNGBDBM24971(({[(benzyloxy)carbonyl]amino}methyl)(methyl)sulfan...)
Affinity DataKi:  1.40E+4nM ΔG°:  -28.2kJ/mole IC50: 1.58E+5nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532156(CHEMBL4587997)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173593((E)-2((E)-(4-Hydroxybenzylidin)hydrazono)thiazolid...)
Affinity DataIC50: 1.46E+4nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532150(CHEMBL4521852)
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532162(CHEMBL4446149)
Affinity DataIC50: 1.69E+4nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM181104(3-Lauroyl-(4-hydroxycoumarin) (6))
Affinity DataIC50: 1.71E+4nMT: 2°CAssay Description:Reaction mixtures comprising one unit of urease enzyme (B. pasteurii) solution and 55 uL of buffers containing 100 mMol urea were incubated with 5 uL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetUrease subunit alpha/beta/gamma(Bacillus pasteurii)
Wroclaw University of Technology

LigandPNGBDBM24971(({[(benzyloxy)carbonyl]amino}methyl)(methyl)sulfan...)
Affinity DataKi:  1.75E+4nM ΔG°:  -27.6kJ/mole IC50: 1.12E+5nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532144(CHEMBL4474805)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha/beta/gamma(Bacillus pasteurii)
Wroclaw University of Technology

LigandPNGBDBM24967(methyl[(methylamino)methyl]phosphinic acid | organ...)
Affinity DataKi:  1.80E+4nM ΔG°:  -27.5kJ/mole IC50: 6.00E+4nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221052(7-(4-Benzoylpiperazin-1-yl)-1-cyclopropyl-6-fluoro...)
Affinity DataIC50: 1.89E+4nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Minia University

LigandPNGBDBM221054(7-(4-((4-((E)-3-(Phenylacryloyl)phenylcarbamoyl)me...)
Affinity DataIC50: 1.93E+4nMAssay Description:The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetUrease subunit alpha/beta/gamma(Bacillus pasteurii)
Wroclaw University of Technology

LigandPNGBDBM24962([(2-aminoacetamido)methyl](methyl)phosphinic acid ...)
Affinity DataKi:  2.10E+4nM ΔG°:  -27.1kJ/mole IC50: 6.00E+4nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMT: 2°CAssay Description:Reaction mixtures comprising one unit of urease enzyme (B. pasteurii) solution and 55 uL of buffers containing 100 mMol urea were incubated with 5 uL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.13E+4nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha/beta/gamma(Bacillus pasteurii)
Wroclaw University of Technology

LigandPNGBDBM24965({[(2S)-2-amino-3-(benzyloxy)propanamido]methyl}(me...)
Affinity DataKi:  2.50E+4nM ΔG°:  -26.7kJ/mole IC50: 8.00E+4nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173592((E)-2-((E)-(3,5-Dichloro-2-hydroxybenzylidene)hydr...)
Affinity DataIC50: 2.67E+4nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173589((E)-2((E)-(4-Nitrobenzylidene)hydrazono)thiazolidi...)
Affinity DataIC50: 2.69E+4nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit alpha [F36L]/beta/gamma(Proteus vulgaris)
Wroclaw University of Technology

LigandPNGBDBM24967(methyl[(methylamino)methyl]phosphinic acid | organ...)
Affinity DataKi:  2.70E+4nM ΔG°:  -26.5kJ/mole IC50: 1.53E+5nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50099857(acetohydroxamic acid | AHA | Acethydroxamsaeure | ...)
Affinity DataIC50: 2.92E+4nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM181106(3-(Methanesulfonoyl)-(4-hydroxycoumarin) (11))
Affinity DataIC50: 2.95E+4nMT: 2°CAssay Description:Reaction mixtures comprising one unit of urease enzyme (B. pasteurii) solution and 55 uL of buffers containing 100 mMol urea were incubated with 5 uL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetUrease subunit alpha [F36L]/beta/gamma(Proteus vulgaris)
Wroclaw University of Technology

LigandPNGBDBM24962([(2-aminoacetamido)methyl](methyl)phosphinic acid ...)
Affinity DataKi:  3.00E+4nM ΔG°:  -26.2kJ/mole IC50: 8.60E+4nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM181102(3-Nonanoyl-(4-hydroxycoumarin) (4))
Affinity DataIC50: 3.09E+4nMT: 2°CAssay Description:Reaction mixtures comprising one unit of urease enzyme (B. pasteurii) solution and 55 uL of buffers containing 100 mMol urea were incubated with 5 uL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetUrease subunit alpha(Escherichia coli)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532163(CHEMBL4557719)
Affinity DataIC50: 3.12E+4nMAssay Description:Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit alpha [F36L]/beta/gamma(Proteus vulgaris)
Wroclaw University of Technology

LigandPNGBDBM24965({[(2S)-2-amino-3-(benzyloxy)propanamido]methyl}(me...)
Affinity DataKi:  3.26E+4nM ΔG°:  -26.0kJ/mole IC50: 1.83E+5nMpH: 7.0 T: 2°CAssay Description:Progress curves were obtained by initiation of urease reaction with addition of purified enzyme into assay mixtures containing increasing concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetUrease subunit alpha(Bacillus pasteurii)
Hazara University

LigandPNGBDBM173594((E)-2((E)-(3-Bromo-4,5-dimethoxybenzylidene)hydraz...)
Affinity DataIC50: 3.66E+4nMpH: 7.0Assay Description:This assay was modified from Berthelot assay and was employed for the determination of urease activity. The assay is based on the hydrolysis of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
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