Compile Data Set for Download or QSAR
Report error Found 436 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [850-1154]'
TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 5 | trans-2-[4-[2-[1-Hydroxyet...)
Affinity DataEC50:  10.8nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  44.4nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  3.48nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449878(trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(trideuterio...)
Affinity DataEC50:  3.46nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 5 | trans-2-[4-[2-[1-Hydroxyet...)
Affinity DataEC50:  8.41nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449880(cis-2-[4-[2-[1-Hydroxyethyl]-6-(methylamino)imidaz...)
Affinity DataEC50:  508nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449881(cis-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(methylamino)i...)
Affinity DataEC50:  129nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM50434787(CHEMBL2386635 | US10703751, Example 644 of WO20110...)
Affinity DataEC50:  0.340nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449883(US10703751, Example 641 of WO2011086053)
Affinity DataEC50:  6.81nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458956(US10759793, Example 100)
Affinity DataIC50: 0.5nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458861(US10759793, Example 14)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458865(US10759793, Example 18)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458867(US10759793, Example 20)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458879(US10759793, Example 31)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458940(US10759793, Example 85)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458942(US10759793, Example 86)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458958(US10759793, Example 102)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458959(US10759793, Example 103)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458962(US10759793, Example 106)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458864(US10759793, Example 17)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458866(US10759793, Example 19)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458880(US10759793, Example 32)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458882(US10759793, Example 34)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458884(US10759793, Example 36)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458885(US10759793, Example 37)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458906(US10759793, Example 53)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458933(US10759793, Example 78)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458934(US10759793, Example 79)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458935(US10759793, Example 80)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458939(US10759793, Example 84)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458953(US10759793, Example 97)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458955(US10759793, Example 99)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458957(US10759793, Example 101)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458961(US10759793, Example 105)
Affinity DataIC50: 2nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458929(US10759793, Example 74)
Affinity DataIC50: 3nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458932(US10759793, Example 77)
Affinity DataIC50: 3nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458936(US10759793, Example 81)
Affinity DataIC50: 3nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458951(US10759793, Example 95)
Affinity DataIC50: 3nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458954(US10759793, Example 98)
Affinity DataIC50: 3nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458859(US10759793, Example 12)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458860(US10759793, Example 13)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458863(US10759793, Example 16)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458878(US10759793, Example 30)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458886(US10759793, Example 38)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458888(US10759793, Example 40)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458891(US10759793, Example 43)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458893(US10759793, Example 45)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458916(US10759793, Example 62)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458960(US10759793, Example 104)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458876(US10759793, Example 28)
Affinity DataIC50: 5nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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