Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with Target = 'Tumor necrosis factor receptor superfamily member 16'
TargetTumor necrosis factor receptor superfamily member 16(Mouse)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50535058(CHEMBL4439582)
Affinity DataEC50:  20nMAssay Description:Activation of p75NTR in mouse hippocampal neurons assessed as increase in cell survival after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTumor necrosis factor receptor superfamily member 16(Mouse)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50535059(CHEMBL4446977)
Affinity DataEC50: <10nMAssay Description:Activation of p75NTR in C57BL/6 mouse brain assessed as suppression of carbachol-mediated persistant firing of entorhinal cortex after 15 mins by cur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50029495(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Affinity DataIC50: 200nMAssay Description:Inhibition of [125I]- NGF binding to extracellular domain of p75 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50029497(2-Methyl-7-oxo-5-(tetrazol-1-ylcarbamoyl)-4,7-dihy...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of [125I]- NGF binding to extracellular domain of p75 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50029494(2-Methyl-7-oxo-4,7-dihydro-thieno[3,2-b]pyridine-3...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of [125I]- NGF binding to extracellular domain of p75 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50029496(6-Amino-4-oxo-1,4-dihydro-quinoline-2-carboxylic a...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of [125I]- NGF binding to extracellular domain of p75 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: 3.72E+3nMAssay Description:Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50029495(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of mouse NGF binding to p75 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50396070(CHEMBL1397270)
Affinity DataIC50: 2.44E+5nMAssay Description:Inhibition of mouse NGF binding to p75 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of mouse NGF binding to p75 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50182020(2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-m...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to NT by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to neurotrophin receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed