Compile Data Set for Download or QSAR
Report error Found 1026 Enz. Inhib. hit(s) with Target = 'Similar to alpha-tubulin isoform 1'
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50069693(CHEMBL3400854)
Affinity DataKd:  2.10E+4nMAssay Description:Binding affinity to bovine brain tubulin assessed as reduction in tubulin intrinsic tryptophan fluorescence intensity incubated for 45 mins by spectr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50069694(CHEMBL3400853)
Affinity DataKd:  2.60E+4nMAssay Description:Binding affinity to bovine brain tubulin assessed as reduction in tubulin intrinsic tryptophan fluorescence intensity incubated for 45 mins by spectr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50069695(CHEMBL3400852)
Affinity DataKd:  4.40E+4nMAssay Description:Binding affinity to bovine brain tubulin assessed as reduction in tubulin intrinsic tryptophan fluorescence intensity incubated for 45 mins by spectr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50069696(CHEMBL3400851)
Affinity DataKd:  5.50E+4nMAssay Description:Binding affinity to bovine brain tubulin assessed as reduction in tubulin intrinsic tryptophan fluorescence intensity incubated for 45 mins by spectr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50369526(CHEMBL1627477)
Affinity DataEC50: >4.00E+5nMAssay Description:Effective concentration for enhancement of tubulin assembly rate was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50089338(Acetic acid 1-acetoxy-9-ethoxy-12a-methyl-5-oxo-1,...)
Affinity DataEC50: >4.00E+5nMAssay Description:Effective concentration for enhancement of tubulin assembly rate was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50089343(Acetic acid 9-ethoxy-1-hydroxy-12a-methyl-6-oxo-1,...)
Affinity DataEC50:  3.60E+5nMAssay Description:Effective concentration for enhancement of tubulin assembly rate was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50089344(Acetic acid 1-acetoxy-9-ethoxy-6-methoxyimino-12a-...)
Affinity DataEC50: >2.00E+5nMAssay Description:Effective concentration for enhancement of tubulin assembly rate was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50089352(N-(9-Ethoxy-1,8-dihydroxy-12a-methyl-1,2,3,3a,3b,4...)
Affinity DataEC50: >2.00E+5nMAssay Description:Effective concentration for enhancement of tubulin assembly rate was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50089350(Acetic acid 9-ethoxy-8-hydroxy-12a-methyl-6-oxo-1,...)
Affinity DataEC50:  8.20E+3nMAssay Description:Effective concentration for enhancement of tubulin assembly rate was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50504214(CHEMBL4530425)
Affinity DataKd:  320nMAssay Description:Inhibition of [3H] colchicine binding to bovine brain tubulin incubated for 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50504215(CHEMBL4463939)
Affinity DataKd:  540nMAssay Description:Inhibition of [3H] colchicine binding to bovine brain tubulin incubated for 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50005480(combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...)
Affinity DataKd:  310nMAssay Description:Inhibition of [3H] colchicine binding to bovine brain tubulin incubated for 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50633530(CHEMBL5437532)
Affinity DataKd:  20nMAssay Description:Displacement of fluorescent probe (R)-(+)-ethyl 5-amino2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate from calf brain tubulin colchi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50633531(CHEMBL5418923)
Affinity DataKd:  960nMAssay Description:Displacement of fluorescent probe (R)-(+)-ethyl 5-amino2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate from calf brain tubulin colchi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50474621(CHEMBL8953)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration required against MAP-rich tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50156464(CHEMBL3793652)
Affinity DataIC50: 150nMAssay Description:Inhibition of bovine tubulin polymerization after 1 hr by fluorescence spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50145077(CHEMBL3764535)
Affinity DataIC50: 250nMAssay Description:Inhibition of bovine tubulin assembly after 15 mins by turbidimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50510963(D-24851 | Indibulin | ZIO-301)
Affinity DataIC50: 250nMAssay Description:Inhibition of bovine brain tubulin polymerization incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50474611(CHEMBL99988)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration required against MAP-rich tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50147362(ST-3100 | CHEMBL330407)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration required against MAP-rich tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528631(CHEMBL4526719)
Affinity DataIC50: 300nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50037450(2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin...)
Affinity DataIC50: 320nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528630(CHEMBL4440494)
Affinity DataIC50: 340nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528642(CHEMBL4447541)
Affinity DataIC50: 350nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50037463(2-(3-Methoxy-phenyl)-6-morpholin-4-yl-1H-quinolin-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528635(CHEMBL4473254)
Affinity DataIC50: 360nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50472344(CHEMBL132896)
Affinity DataIC50: 370nMAssay Description:Concentration inhibiting tubulin polymerization (ITP)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50037454(6-(3-Chloro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin...)
Affinity DataIC50: 370nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50513145(CHEMBL4559526)
Affinity DataIC50: 370nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition and measured for 20 mins by turbidimetry-based sp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528629(CHEMBL4524533)
Affinity DataIC50: 370nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528638(CHEMBL4442113)
Affinity DataIC50: 370nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50037448(6-Dimethylamino-2-(3-methoxy-phenyl)-1H-quinolin-4...)
Affinity DataIC50: 380nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50508919(CHEMBL4459174)
Affinity DataIC50: 380nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition and measured for 20 mins by turbidimetry-based sp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50513135(CHEMBL4474504)
Affinity DataIC50: 390nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition and measured for 20 mins by turbidimetry-based sp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528636(CHEMBL4464909)
Affinity DataIC50: 390nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50212990(CHEMBL59709)
Affinity DataIC50: 400nMAssay Description:In vitro inhibitory activity against bovine brain tubulin assembly at a concentration of 3-3.5 mg/mlMore data for this Ligand-Target Pair
In DepthDetails

TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50212990(CHEMBL59709)
Affinity DataIC50: 400nMAssay Description:In vitro inhibitory activity against bovine brain tubulin assembly at a concentration of 3-3.5 mg/mlMore data for this Ligand-Target Pair
In DepthDetails

TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50156812(PHENSTATIN)
Affinity DataIC50: 400nMAssay Description:Inhibitory concentration required against MAP-rich tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50474616(CHEMBL9011)
Affinity DataIC50: 400nMAssay Description:Inhibitory concentration required against MAP-rich tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50078205(CHEMBL3414643)
Affinity DataIC50: 410nMAssay Description:Inhibition of bovine brain tubulin polymerization incubated for 60 mins by microplate reader based turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50473762(CHEMBL90904)
Affinity DataIC50: 410nMAssay Description:Inhibition of tubulin (10 uM) polymerization, after a 20 min incubation at 30 degrees CentigradeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528641(CHEMBL4436465)
Affinity DataIC50: 410nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528633(CHEMBL4522990)
Affinity DataIC50: 420nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50005480(combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...)
Affinity DataIC50: 440nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50037450(2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin...)
Affinity DataIC50: 440nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50528634(CHEMBL4554434)
Affinity DataIC50: 440nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50470020(CHEMBL325260)
Affinity DataIC50: 450nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50035218(podophyllotoxin | CHEMBL61 | Podophyllinic acid la...)
Affinity DataIC50: 460nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50035218(podophyllotoxin | CHEMBL61 | Podophyllinic acid la...)
Affinity DataIC50: 460nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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