Compile Data Set for Download or QSAR
Report error Found 883 Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 1'
TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019142(CHEMBL3288777)
Affinity DataKd:  6.82E+3nMAssay Description:Binding affinity to TPH-1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243022((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243655((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3...)
Affinity DataEC50:  63nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243619((S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2...)
Affinity DataEC50:  70nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243618((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...)
Affinity DataEC50:  48nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243617((S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'...)
Affinity DataEC50:  56nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243024((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(n...)
Affinity DataEC50:  510nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243023((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50630639(CHEMBL5404510)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to THP1 (unknown origin) assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341451(US9765092, Example 1.23.1 | 2-((2-chloro-6-morphol...)
Affinity DataIC50: 2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341466(US9765092, Example 1.24.1 | 5-(6-(2-((2-chloro-6-m...)
Affinity DataIC50: 2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341518(US9765092, Example 1.32.1 | 2-((2-chloro-6-morphol...)
Affinity DataIC50: 2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341523(US9765092, Example 1.33.1 | 1-(5-(5-chloro-3-fluor...)
Affinity DataIC50: 2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341652(US9765092, Example 6.9.1 | 5-(6-(2-(2-chloro-4-(me...)
Affinity DataIC50: 2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341713(US9765092, Example 1.4.17 | 1-(6-Chloro-5-(2-(5-(4...)
Affinity DataIC50: 2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341725(US9765092, Example 1.4.33 | 2-((6-(2-Oxa-5-azabicy...)
Affinity DataIC50: 2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341346(US9765092, Example 1.4.38 | 1-(5-(4-chloro-2-fluor...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341391(US9765092, Example 1.6.17 | 2-((2-chloro-6-morphol...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341396(US9765092, Example 1.6.22 | 2-((2-chloro-6-(dimeth...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341430(US9765092, Example 1.14.8 | 6-chloro-5-(2-(5-(5-cy...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341638(US9765092, Example 6.4.8 | N-(6-chloro-5-(2-(5-(4-...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341710(US9765092, Example 1.4.14 | 1-(5-(4-Chloro-2-fluor...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341714(US9765092, Example 1.4.18 | 1-(5-(4-Chloro-2-fluor...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341715(US9765092, Example 1.4.20 | 1-(5-(4-Chloro-2-fluor...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341724(US9765092, Example 1.4.32 | 1-(5-(4-Chloro-2-fluor...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341728(US9765092, Example 1.4.37 | 1-(5-(4-Chloro-2-fluor...)
Affinity DataIC50: 3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341327(US9765092, Example 1.3.1 | 2-(2-chloro-4-(morpholi...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341333(US9765092, Example 1.4.3 | 1-(5-(4-chloro-2-fluoro...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341348(US9765092, Example 1.4.40 | 2-((4-chloro-2-(dimeth...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341387(US9765092, Example 1.6.13 | 1-(5-(4-cyclopropyl-2-...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341399(US9765092, Example 1.6.25 | 6-chloro-5-(2-(5-(4-cy...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341419(US9765092, Example 1.11.3 | 2-((2-chloro-6-morphol...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341423(US9765092, Example 1.14.1 | 2-((2-chloro-6-morphol...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341431(US9765092, Example 1.14.9 | 2-((2-chloro-5-fluoro-...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341432(US9765092, Example 1.14.10 | 2-((2-chloro-6-(methy...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341476(US9765092, Example 1.24.11 | (R)-6-chloro-5-(2-(5-...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341524(US9765092, Example 1.33.2 | 1-(5-(5-chloro-3-fluor...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341617(US9765092, Example 6.1.1 | 1-(5-(3,4-dimethoxyphen...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341629(US9765092, Example 6.3.3 | 1-(5-(2-fluoro-4-methox...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341632(US9765092, Example 6.4.2 | 1-((5R)-5-(4-chloro-2-f...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341636(US9765092, Example 6.4.6 | 1-(5-(4-chloro-2-fluoro...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341644(US9765092, Example 6.6.1 | 2-((2-chloro-6-morpholi...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341726(US9765092, Example 1.4.34 | 1-(5-(4-Chloro-2-fluor...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341334(US9765092, Example 1.4.4 | 1-(5-(4-chloro-2-fluoro...)
Affinity DataIC50: 5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341341(US9765092, Example 1.4.19 | 6-chloro-5-(2-(5-(4-ch...)
Affinity DataIC50: 5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341342(US9765092, Example 1.4.21 | 6-chloro-5-(2-(5-(4-ch...)
Affinity DataIC50: 5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341347(US9765092, Example 1.4.39 | N-(6-chloro-5-(2-(5-(4...)
Affinity DataIC50: 5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341439(US9765092, Example 1.16.1 | 1-(5-(6-chloro-2-fluor...)
Affinity DataIC50: 5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341445(US9765092, Example 1.16.7 | 1-(5-(6-chloro-2-fluor...)
Affinity DataIC50: 5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM341450(US9765092, Example 1.21.1 | Methyl 5-(6-(2-((2-chl...)
Affinity DataIC50: 5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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