Compile Data Set for Download or QSAR
Report error Found 514 Enz. Inhib. hit(s) with Target = 'Tryptase'
TargetTryptase gamma(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093142(APC-1390 | 1N-(3,3-diphenylpropyl)-4-[4-amino(imin...)
Affinity DataKd:  0.0700nMAssay Description:Dissociation constant of compound was evaluated from its IC50 against tryptase at different concentrationsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase gamma(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093142(APC-1390 | 1N-(3,3-diphenylpropyl)-4-[4-amino(imin...)
Affinity DataKd:  0.0700nMAssay Description:Dissociation constant of compound was evaluated from its IC50 against tryptase at different concentrationsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase gamma(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093153(Derivative of APC-2059 | CHEMBL306620)
Affinity DataKd:  0.100nMAssay Description:Dissociation constant of compound was evaluated from its IC50 against tryptase at different concentrationsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217812(CHEMBL322526)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217626(CHEMBL322538)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217627(CHEMBL110061)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144535((R)-4-Oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-1-ca...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144582((R)-1-[4-(6-Naphthalen-2-yl-hexanoyl)-piperazine-1...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144535((R)-4-Oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-1-ca...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144577((R)-1-[4-(6-Naphthalen-1-yl-hexanoyl)-piperazine-1...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144586((R)-1-[4-(7-Naphthalen-1-yl-heptanoyl)-piperazine-...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144555((R)-1-{4-[2-(4-Benzyloxy-phenyl)-acetyl]-piperazin...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217599(CHEMBL109888)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217622(CHEMBL443539)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217801(CHEMBL111250)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120387(BMS-363131 | (2S,3R)-3-((R)-1-Carbamimidoyl-piperi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217824(BMS-363130 | CHEMBL70738)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50221046(CHEMBL72282)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120387(BMS-363131 | (2S,3R)-3-((R)-1-Carbamimidoyl-piperi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120387(BMS-363131 | (2S,3R)-3-((R)-1-Carbamimidoyl-piperi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217817(CHEMBL326209)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217818(CHEMBL440515)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217822(CHEMBL111173)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217823(CHEMBL111630)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217824(BMS-363130 | CHEMBL70738)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144532((2S,3R)-4-Oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217819(CHEMBL109504)
Affinity DataIC50: 1.90nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity of compound was determined against human Tryptase betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217628(CHEMBL107493)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50220841(BMS-262084 | CHEMBL71037)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217813(CHEMBL302058)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144558((R)-1-[4-(4-Benzyloxy-benzoyl)-piperazine-1-carbon...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120368((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120368((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217624(CHEMBL321622)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217813(CHEMBL302058)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120368((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217820(CHEMBL447534)
Affinity DataIC50: 4.60nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144588((R)-4-Oxo-1-[4-(7-phenyl-heptanoyl)-piperazine-1-c...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144561((R)-4-Oxo-1-{4-[3-(3-oxo-4-p-tolyl-3H-pyrrol-2-yl)...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144557((R)-4-Oxo-1-[4-(8-phenyl-octanoyl)-piperazine-1-ca...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144580((R)-1-(4-{4-[3-(4-Chloro-phenyl)-[1,2,4]oxadiazol-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144569((R)-1-[4-(2-Biphenyl-4-yl-acetyl)-piperazine-1-car...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144575((R)-4-Oxo-1-{4-[2-(4-phenoxy-phenyl)-acetyl]-piper...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217623(CHEMBL109947)
Affinity DataIC50: 5nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50220841(BMS-262084 | CHEMBL71037)
Affinity DataIC50: 5nMAssay Description:Inhibition of human lung tryptase using Z-glypro-arg-AMC incubated for 3 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50220841(BMS-262084 | CHEMBL71037)
Affinity DataIC50: 5nMAssay Description:Inhibition of human tryptaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTryptase delta(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217805(CHEMBL111548)
Affinity DataIC50: 5.20nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144564((R)-4-Oxo-1-{4-[4-(3-phenyl-propyl)-benzoyl]-piper...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144579((R)-1-[4-(4-Benzyloxycarbonylamino-butyryl)-pipera...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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