Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with Target = 'Transmembrane protease serine 2'
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606675(CHEMBL3219079)
Affinity DataKi:  0.900nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639179(CHEMBL5560415)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TMPRSS2 (unknown origin) using Boc-Gln-Ala-Arg-AMC as peptide substrate pre-incubated with compound for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606676(CHEMBL3219087)
Affinity DataKi:  1nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639184(CHEMBL5557551)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639175(CHEMBL5558547)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50649147(CHEMBL5620212)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human TMPRSS2 using fluorogenic substrate preincubated with enzyme in dark for 45 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM525152(US10988505, Example 2 | N-0385 | Ms-QFR-kbt)
Affinity DataIC50: 1.90nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639173(CHEMBL5555448)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606671(CHEMBL3219102)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606673(CHEMBL3219100)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606672(CHEMBL3219101)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606674(CHEMBL3219103)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50032698(CHEMBL3354676 | N-0130)
Affinity DataIC50: 3.10nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639180(CHEMBL5559738)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50424712(Camostat Mesilate | Foipan | CAMOSTAT)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM525153(US10988505, Example 3 | N-0386 | Ac-QFR-kbt)
Affinity DataIC50: 3.90nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50649148(CHEMBL5619680)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human TMPRSS2 using fluorogenic substrate preincubated with enzyme in dark for 45 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639182(CHEMBL5559988)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataIC50: 5.20nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639176(CHEMBL5560759)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM736194((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  10nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639183(CHEMBL5568169)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639174(CHEMBL5562350)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639185(CHEMBL5558228)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639181(CHEMBL5556134)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639177(CHEMBL5564865)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639178(CHEMBL5557087)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM736193((4S,4'S)-6-chloro-4'-[(isopropylamino)methyl]-1'-(...)
Affinity DataEC50:  17nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50: 18nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  19nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50639172(CHEMBL5561725)
Affinity DataIC50: 22nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM736195((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  32nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM736197((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  52nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50349344(CHEMBL1809250)
Affinity DataKi:  53nMAssay Description:Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50349345(CHEMBL1809251)
Affinity DataKi:  68nMAssay Description:Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50635841(CHEMBL1185793)
Affinity DataIC50: 70nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM513874(bioRxiv20220126.477782, Screening Hit 2 | bioRxiv2...)
Affinity DataEC50:  370nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details

TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50114539(Otamixaban | (2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-...)
Affinity DataIC50: 620nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50239965(CHEBI:77032 | Bromhexine)
Affinity DataIC50: 750nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM420291(0591-5329 | 4-(Methoxycarbonyl)phenyl thiophene-2-...)
Affinity DataIC50: 930nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50424712(Camostat Mesilate | Foipan | CAMOSTAT)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of human TMPRSS2-mediated SARS-CoV-2 entry into human Caco-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM45440(4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarbox...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of TMPRSS2 (247 to 492 residues) (unknown origin) peptidase domain expressed in Escherichia coli BL21 (DE3) incubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50084952(4'-Carbamimidoyl-2'-methyl-biphenyl-4-carboxylic a...)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) using Boc-Gln-Ala-Arg-AMC as peptide substrate pre-incubated with compound for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50022172(CHEMBL275000 | cid_5395514 | (7-Hydroxy-2-oxo-2H-c...)
Affinity DataIC50: 1.37E+3nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM50442879(Tannic Acid)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of human recombinant TMPRSS2 using Boc-Gln-Ala-Arg-AMC as peptide substrate pre-incubated with compound for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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