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Report error Found 1612 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8'
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50037023(CHEBI:17447 | Geraniol)
Affinity DataEC50:  5.90E+6nMAssay Description:Agonist activity at TRPM8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50329105(19(S)-Heyneanine | voacristine | CHEMBL463317)
Affinity DataEC50:  2.70E+4nMAssay Description:Agonist activity at mouse TRPM8 expressed in T-REx HEK cells assessed as increase in intracellular Ca2+ accumulation by Fluo-4 AM dye based fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083005(CHEMBL3422799)
Affinity DataEC50:  140nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082783(CHEMBL3422798)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082781(CHEMBL3422796)
Affinity DataEC50:  130nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082780(CHEMBL1451030)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082778(CHEMBL3422794)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083006(CHEMBL3422800)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083008(CHEMBL3422802)
Affinity DataEC50:  1.54E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083012(CHEMBL3422806)
Affinity DataEC50:  890nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083013(CHEMBL3422807)
Affinity DataEC50:  620nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083014(CHEMBL3422808)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083015(CHEMBL3422809)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083016(CHEMBL3422810)
Affinity DataEC50:  600nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083017(CHEMBL3422811)
Affinity DataEC50:  300nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083018(CHEMBL3422812)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at rat recombinant TRPM8 receptor expressed in HEK293 cells assessed as increase in intracellular calcium concentration by fluorimet...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  7.50E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50159506(CHEMBL3787319)
Affinity DataEC50:  4.00E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50441018(CHEMBL67100)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as induction of intracellular calcium influx by Fluo-4-AM dye-based ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50329104(Indole alkaloid derivative | voacangine | CHEMBL18...)
Affinity DataKd:  7.94E+3nMAssay Description:Competitive antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  300nMAssay Description:Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50442649(CHEMBL2441929)
Affinity DataEC50:  40nMAssay Description:Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420658(CHEMBL2087053)
Affinity DataEC50:  4.58E+4nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420659(CHEMBL2087075)
Affinity DataEC50:  4.34E+4nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50240432(5-methyl-2-(propan-2-yl)phenol | thymol | 1-hydrox...)
Affinity DataEC50:  5.22E+4nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420662(CHEMBL1385022)
Affinity DataEC50:  5.10E+3nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420691(CHEMBL2087061)
Affinity DataEC50:  4.80E+3nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420677(CHEMBL2087057)
Affinity DataEC50:  270nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420678(CHEMBL2087056)
Affinity DataEC50:  1.70E+3nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420679(CHEMBL2087055)
Affinity DataEC50:  850nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420681(CHEMBL2087052)
Affinity DataEC50:  600nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420675(CHEMBL2087059)
Affinity DataEC50:  440nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataKd:  1.44E+4nMAssay Description:Binding affinity to human TRPM8 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  2.90E+4nMAssay Description:Activity at human TRPM8 expressed in HEK293 cells assessed as compound concentration causing leftward shift of voltage for half maximal activationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  60nMAssay Description:Activation of TRPM8 channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268715(CHEMBL4090221)
Affinity DataEC50:  889nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268716(CHEMBL4069157)
Affinity DataEC50:  1.10E+4nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268717(CHEMBL4091126)
Affinity DataEC50:  93nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268718(CHEMBL4071883)
Affinity DataEC50:  5.20E+4nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268719(CHEMBL4093598)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268720(CHEMBL4067021)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268722(CHEMBL4086590)
Affinity DataEC50:  489nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268723(CHEMBL4093292)
Affinity DataEC50:  2.18E+4nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268724(CHEMBL4091381)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268728(CHEMBL4087469)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268729(CHEMBL4060261)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50268730(CHEMBL4091183)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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