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Report error Found 322 Enz. Inhib. hit(s) with Target = 'Transcriptional enhancer factor TEF-4'
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50580860(CHEMBL5090029)
Affinity DataKd:  3.50E+4nMAssay Description:Binding affinity to eGFP-fused human TEAD2 (217 to 447 residues) expressed in CHO-K1 cells by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50580858(CHEMBL5082195)
Affinity DataKd:  5.10E+3nMAssay Description:Binding affinity to eGFP-fused human TEAD2 (217 to 447 residues) expressed in CHO-K1 cells by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50580859(CHEMBL5089646)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to eGFP-fused human TEAD2 (217 to 447 residues) expressed in CHO-K1 cells by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM626316(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataEC50:  100nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataEC50:  70nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626318(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataEC50:  30nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626319(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataEC50:  50nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626320(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626321(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataEC50:  2.80E+3nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626322(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataEC50:  180nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626323(methyl 2-[[[4-cyano-7-(4- isopropylphenyl)-2,3- ...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626324(US11787775, Compound 29 | 2-[[[4-cyano-7-(4-isopro...)
Affinity DataEC50:  50nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626325(1-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataEC50:  2.10E+3nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataEC50:  130nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626327(2-[[[4-(hydroxymethyl)-7-(4- isopropylphenyl)-2,3...)
Affinity DataEC50:  300nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626328(2-[[[4-(hydroxymethyl)-7-(4- isopropylphenyl)-2,3...)
Affinity DataEC50:  40nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626329(2-[[[4-(hydroxymethyl)-7-(4- isopropylphenyl)-2,3...)
Affinity DataEC50:  70nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626330(2-[[[4-cyano-7-[4- (trifluoromethyl)phenyl]-2,3- ...)
Affinity DataEC50:  380nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626331(US11787775, Compound 16-C)
Affinity DataEC50:  20nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626332(US11787775, Compound 16-D)
Affinity DataEC50:  70nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626333(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataEC50:  90nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataEC50:  190nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataEC50:  40nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626336(2-[[[4-fluoro-7-(4-isopropylphenyl)- 2,3-dihydrob...)
Affinity DataEC50: <10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626337(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrofu...)
Affinity DataEC50:  60nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626338(2-[[[7-cyano-4-[4-(1,1- difluoroethyl)phenyl]-1,3...)
Affinity DataEC50:  260nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626342(2-[[[4-cyano-7-(2-fluoro-4- isopropyl-phenyl)-2,3...)
Affinity DataEC50:  40nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataEC50:  580nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626344(2-[[[7-cyano-4-[4- (trifluoromethoxy)phenyl]-1,3-...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626345(2-[[[4-cyano-7-(5-isopropyl-2- pyridyl)-2,3-dihyd...)
Affinity DataEC50:  1.90E+3nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626346(2-[[[7-(4-isopropylphenyl)-4- methylsulfonyl-2,3-...)
Affinity DataEC50:  80nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50600845(CHEMBL5173440)
Affinity DataKd:  4.30E+4nMAssay Description:Binding affinity to human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 Star (DE3) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50600846(CHEMBL5170406)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 Star (DE3) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50580860(CHEMBL5090029)
Affinity DataKd:  3.50E+4nMAssay Description:Binding affinity to TEAD2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50626279(CHEMBL5440009)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to SA sensor chip immobilized N-terminal avi-tagged biotinylated TEAD2 YAP binding domain (unknown origin) assessed as binding const...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50626280(CHEMBL5417138)
Affinity DataKd:  229nMAssay Description:Binding affinity to SA sensor chip immobilized N-terminal avi-tagged biotinylated TEAD2 YAP binding domain (unknown origin) assessed as binding const...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 2.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50630292(US12110276, Compound 49 | CHEMBL5408536)
Affinity DataIC50: 2.70nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50630292(US12110276, Compound 49 | CHEMBL5408536)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50629170(CHEMBL5419829)
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50629172(CHEMBL5401444)
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 3.20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM699467((S,E)-1-(3-(1-(Prop-1-en-1- ylsulfonyl)azetidin-3-...)
Affinity DataIC50: 3.40nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM699408((E)-3-chloro-1-[3-[4-(hydroxymethyl)- 1-[4- (trifl...)
Affinity DataIC50: 3.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM699395(cyclobuten-1-yl-[3-[4- (hydroxymethyl)-1-[4- (trif...)
Affinity DataIC50: 3.60nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Lille Neuroscience and Cognition Research Center

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 3.80nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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