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Report error Found 102 Enz. Inhib. hit(s) with Target = 'Thyrotropin receptor'
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50189778(cid_9887381 | N-tert-butyl-5-amino-4-(3-methoxyphe...)
Affinity DataEC50:  6.50E+3nMAssay Description:Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614104(CHEMBL5283477)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614117(CHEMBL5275472)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614128(CHEMBL5281228)
Affinity DataIC50: 11nMAssay Description:Allosteric antagonist activity at human TSHR expressed in CHO cells assessed as inhibition of bTSH-induced cAMP production incubated for 2 hrs by lum...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM60862(BDBM189328 | US9174940, 32)
Affinity DataIC50: 12nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614109(CHEMBL5285685)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614110(CHEMBL5270266)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614106(CHEMBL5275619)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614107(CHEMBL5288869)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614108(CHEMBL5290721)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as inhibition of M22-induced cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614117(CHEMBL5275472)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614125(CHEMBL5270771)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614111(CHEMBL5279687)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614127(CHEMBL5267043)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614105(CHEMBL5287707)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614120(CHEMBL5267166)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614116(CHEMBL5285143)
Affinity DataIC50: 39nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614120(CHEMBL5267166)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614107(CHEMBL5288869)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614110(CHEMBL5270266)
Affinity DataIC50: 46nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM189329(US9174940, Compound C | (+)-(1-Acetyl-4-methyl-4-p...)
Affinity DataIC50: 47nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614108(CHEMBL5290721)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614123(CHEMBL5286556)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614127(CHEMBL5267043)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614123(CHEMBL5286556)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614106(CHEMBL5275619)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614125(CHEMBL5270771)
Affinity DataIC50: 56nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614109(CHEMBL5285685)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614108(CHEMBL5290721)
Affinity DataIC50: 62nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614104(CHEMBL5283477)
Affinity DataIC50: 65nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614119(CHEMBL5271120)
Affinity DataIC50: 68nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614108(CHEMBL5290721)
Affinity DataIC50: 69nMAssay Description:Antagonist activity at human TSHR in HEK293 cells assessed as inhibition of bTSH-induced cAMP production incubated for 2 hrs by Eu-cAMP tracer based ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614119(CHEMBL5271120)
Affinity DataIC50: 71nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614111(CHEMBL5279687)
Affinity DataIC50: 72nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614118(CHEMBL5288635)
Affinity DataIC50: 74nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614121(CHEMBL5280508)
Affinity DataIC50: 76nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614115(CHEMBL5285769)
Affinity DataIC50: 82nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614116(CHEMBL5285143)
Affinity DataIC50: 82nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614112(CHEMBL5267037)
Affinity DataIC50: 83nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614105(CHEMBL5287707)
Affinity DataIC50: 84nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614126(CHEMBL5268829)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM189327(US9174940, Compound A | Hexanoic acid (Compound A))
Affinity DataIC50: 88nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614122(CHEMBL5273361)
Affinity DataIC50: 89nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50614114(CHEMBL5268512)
Affinity DataIC50: 91nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Rat)
Byondis

Curated by ChEMBL
LigandPNGBDBM50614113(CHEMBL5275140)
Affinity DataIC50: 97nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM60843(US9174940, 1)
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM60844(US9174940, 4)
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM60845(US9174940, 6)
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM60847(US9174940, 7)
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThyrotropin receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM60848(US9174940, 26 | US9174940, 11)
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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