Compile Data Set for Download or QSAR
Report error Found 1243 Enz. Inhib. hit(s) with Target = 'Thromboxane-A synthase'
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM10023(5-(Imidazol-1-yl)-5,6,7,8-tetrahydroquinoline | 5-...)
Affinity DataAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM10039(8-(1H-imidazol-1-yl)-5,6,7,8-tetrahydroquinoline |...)
Affinity DataAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM10040(6-(1H-imidazol-1-yl)isoquinoline | CHEMBL299066 | ...)
Affinity DataAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50071137((Z)-7-{3-[(R)-4-(4-Cyclohexyl-butylcarbamoyl)-4,5-...)
Affinity DataKd:  452nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50010960((E)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | CV...)
Affinity DataIC50: 0.890nMAssay Description:In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50026486(7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | Isbogr...)
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50026486(7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | Isbogr...)
Affinity DataIC50: 0.900nMAssay Description:Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003780(CHEMBL435590 | 4-(3-Pyridin-3-yl-propyl)-8-(toluen...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003792(CHEMBL136762 | 8-(4-Fluoro-benzenesulfonylamino)-4...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003784(CHEMBL137402 | 8-(4-Chloro-benzenesulfonylamino)-4...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50043839((E)-6-[2-(4-Fluoro-benzenesulfonylamino)-indan-5-y...)
Affinity DataIC50: 1nMAssay Description:Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50110458(5-(Phenyl-pyridin-3-yl-methyleneaminooxy)-pentanoi...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50109140(5-[1-Phenyl-1-pyridin-3-yl-meth-(Z)-ylideneaminoox...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50109134(5-[1-Pyridin-3-yl-1-{3-[(3-pyridin-3-yl-1H-pyrrolo...)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003803(CHEMBL136738 | 8-(Naphthalene-2-sulfonylamino)-4-(...)
Affinity DataIC50: 1.5nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50109124(5-[1-(3-{[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylme...)
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 2nMAssay Description:The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003801(CHEMBL139372 | 4-(3-Pyridin-3-yl-propyl)-8-(4-trif...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003781(CHEMBL341686 | [5-(4-Chloro-benzenesulfonylamino)-...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50024903(6-Chloro-3-(4-imidazol-1-yl-butyl)-1H-quinazoline-...)
Affinity DataIC50: 2nMAssay Description:Tested for inhibition of thromboxane synthetase from spontaneously hypertensive ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50043826(6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phe...)
Affinity DataIC50: 2nMAssay Description:Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of thromboxane synthetase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetThromboxane-A synthase(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50024948(6-Chloro-3-(7-imidazol-1-yl-heptyl)-1H-quinazoline...)
Affinity DataIC50: 2nMAssay Description:Tested for inhibition of thromboxane synthetase from spontaneously hypertensive ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50038591(6-(5-Chloro-1-methyl-2-pyridin-3-yl-1H-indol-3-yl)...)
Affinity DataIC50: 2nMAssay Description:Tested for 50% inhibition of thromboxane synthase (TxS) in human platelets (in vitro)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50037039(2-Amino-5,7-dimethyl-4-pyridin-3-ylmethyl-benzothi...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against the production of thromboxane B2 (TXB2) in glycogen-induced peritoneal cells of ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50020743(CHEMBL53346 | Sodium; (+)-7-(3-benzenesulfonylamin...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of thromboxane A2 synthetase from human platelets by 1 uM of the compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003797(CHEMBL63904 | 8-(4-Chloro-benzenesulfonylamino)-4-...)
Affinity DataIC50: 2.60nMAssay Description:In vitro inhibition of thromboxane synthetase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50072779((E)-7-{4-[4-(2-Phenoxy-ethylcarbamoyl)-oxazol-2-yl...)
Affinity DataIC50: 2.60nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50072778((E)-7-(4-{4-[3-(4-Methoxy-phenyl)-propylcarbamoyl]...)
Affinity DataIC50: 2.70nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50010960((E)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | CV...)
Affinity DataIC50: 2.90nMAssay Description:Activity against TXA2 synthase in bovine platelet microsomeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50008790(CHEMBL299224 | 5-[Pyridin-4-yl-(3-trifluoromethyl-...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of Thromboxane synthase using [14C]arachidonic acid as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003795(5-[Pyridin-3-yl-(3-trifluoromethyl-phenyl)-methyle...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003798(CHEMBL134580 | 8-(4-Chloro-benzenesulfonylamino)-4...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003799(CHEMBL136934 | 8-(4-Chloro-benzenesulfonylamino)-2...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003800(CHEMBL344457 | 8-(4-Methoxy-benzenesulfonylamino)-...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003796(CHEMBL136371 | 8-(4-Chloro-benzenesulfonylamino)-4...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003797(CHEMBL63904 | 8-(4-Chloro-benzenesulfonylamino)-4-...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM7962(CHEMBL537708 | 4-[2-(1H-imidazol-1-yl)ethoxy]benzo...)
Affinity DataIC50: 3nMAssay Description:Inhibition of TXA2 synthetase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM7962(CHEMBL537708 | 4-[2-(1H-imidazol-1-yl)ethoxy]benzo...)
Affinity DataIC50: 3nMAssay Description:Inhibition of thromboxane TXA2 synthetase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM7962(CHEMBL537708 | 4-[2-(1H-imidazol-1-yl)ethoxy]benzo...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against thromboxane A2 synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM7962(CHEMBL537708 | 4-[2-(1H-imidazol-1-yl)ethoxy]benzo...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of thromboxane synthase from human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50075618(6-{3-[2-cyano-1-cyclopentylamino-(E)-1-iminomethyl...)
Affinity DataIC50: 3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50075637(6-{3-[2-cyano-1-isopentylamino-(E)-1-iminomethylam...)
Affinity DataIC50: 3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50075644((E)-6-[3-({[(E)-Benzenesulfonylimino]-tert-butylam...)
Affinity DataIC50: 3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50075630(6-{3-[1-(1-adamantylamino)-2-cyano-(E)-1-iminometh...)
Affinity DataIC50: 3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50075645(6-{3-[2-cyano-1-cyclohexylamino-(E)-1-iminomethyla...)
Affinity DataIC50: 3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50025953(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid | CGS-1...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetThromboxane-A synthase(Human)
Universitat Des Saarlandes

LigandPNGBDBM50003795(5-[Pyridin-3-yl-(3-trifluoromethyl-phenyl)-methyle...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article

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