Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with Target = 'Stimulator of interferon genes protein [139-379,H232R]'
TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501193(US11021511, Compound 1)
Affinity DataEC50:  1.81E+3nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataEC50:  19nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501361(US11021511, Compound 5)
Affinity DataEC50:  210nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501361(US11021511, Compound 5)
Affinity DataKd: <10nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataEC50:  53nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataKd:  6nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501363(US11021511, Compound 6b)
Affinity DataEC50:  107nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501363(US11021511, Compound 6b)
Affinity DataKd:  1.70nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501364(US11021511, Compound 6c)
Affinity DataEC50:  60nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501364(US11021511, Compound 6c)
Affinity DataKd:  1.70nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataIC50: 10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501361(US11021511, Compound 5)
Affinity DataIC50: 10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataIC50: 10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501363(US11021511, Compound 6b)
Affinity DataIC50: 10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501364(US11021511, Compound 6c)
Affinity DataIC50: 10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501193(US11021511, Compound 1)
Affinity DataIC50: 5.45E+4nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In DepthDetails
US Patent