Compile Data Set for Download or QSAR
Report error Found 826 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 5'
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22222(CHEMBL208924 | 3-(3-methyl-4-{5-[4-(propan-2-yloxy...)
Affinity DataEC50:  40nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22223(3-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1,2,4-o...)
Affinity DataEC50:  6.5nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22224(2-methyl-3-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(t...)
Affinity DataEC50:  9.90nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22225(3-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(trifluorom...)
Affinity DataEC50:  3.90nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22226(3-(5-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1,2,4-o...)
Affinity DataEC50:  28.6nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22227((1S,2S)-2-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(tr...)
Affinity DataEC50:  5.10nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22228((1S,2S)-2-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]...)
Affinity DataEC50:  13.6nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22229((1S,2R)-2-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]...)
Affinity DataEC50:  37.7nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM47493(cid_4780551 | 3-[2-[2,4-bis(chloranyl)phenoxy]etho...)
Affinity DataEC50: >5.00E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM75601(SR-02000000303-1 | CYM50174 | cid_44620882 | SR-02...)
Affinity DataEC50: >5.00E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM75602(3-[2-[2,4-bis(chloranyl)phenoxy]ethoxy]-2,6-bis(br...)
Affinity DataEC50: >5.00E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM75603(CYM50181 | cid_44620879 | (5Z)-5-[[1-[(2,6-difluor...)
Affinity DataEC50:  339nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM75604(CYM50199 | SR-02000000306-1 | cid_44620895 | SR-02...)
Affinity DataEC50: >5.00E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM75606(cid_44620894 | CYM50260 | SR-02000000308 | SR-0200...)
Affinity DataEC50: >5.00E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  44nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041982(CHEMBL3359522)
Affinity DataEC50:  47nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041983(CHEMBL3359523)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041979(CHEMBL3359520)
Affinity DataEC50:  410nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041981(CHEMBL3358955)
Affinity DataEC50:  107nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041979(CHEMBL3359520)
Affinity DataEC50:  410nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041980(CHEMBL3359519)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041980(CHEMBL3359519)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50041981(CHEMBL3358955)
Affinity DataEC50:  107nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50158336(FINGOLIMOD HYDROCHLORIDE | 2-amino-2-(4-octylphene...)
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.300nMpH: 7.4Assay Description:Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM23164(CHEMBL190006 | [(2R)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  4.90nMpH: 7.4Assay Description:Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186379(3-(4-(5-(3-cyano-4-isopropoxyphenyl)furan-2-yl)-3-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186390(3-(4-(5-(3-cyano-4-isopropoxyphenyl)thiophen-3-yl)...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186388(3-(4-(5-(3-cyano-4-isopropoxyphenyl)oxazol-2-yl)-3...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22223(3-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1,2,4-o...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186384(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4-methylthiaz...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186396(3-(4-(4-(3-cyano-4-isopropoxyphenyl)thiophen-2-yl)...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186395(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-oxadiaz...)
Affinity DataEC50:  460nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186381(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4H-1,2,4-tria...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186397(3-(4-(5-(3-cyano-4-isopropoxyphenyl)thiophen-2-yl)...)
Affinity DataEC50:  220nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186382(3-(4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186405(3-(4-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadia...)
Affinity DataEC50:  73nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186377(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-2H-tetrazol-2...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186402(3-(4-(5-(3-cyano-4-isopropoxyphenyl)thiazol-2-yl)-...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186404(3-(4-(5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-...)
Affinity DataEC50:  950nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186393(3-(4-(2-(3-cyano-4-isopropoxyphenyl)-2H-tetrazol-5...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186412(3-(4-(5-(5-chloro-6-isopropoxypyridin-3-yl)-1,3,4-...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186391(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-1-methyl-1H-p...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186380(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4-methyl-4H-1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186916(3-(4-(5-(5-butylpyridin-2-yl)-1,2,4-oxadiazol-3-yl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTP-gamma-S uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM50186917(3-(4-(5-(4-cyclohexylphenyl)-1,2,4-oxadiazol-3-yl)...)
Affinity DataEC50:  591nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTP-gamma-S uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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