Compile Data Set for Download or QSAR
Report error Found 2216 Enz. Inhib. hit(s) with Target = 'Sodium- and chloride-dependent glycine transporter 1'
LigandPNGBDBM50126023((Methyl-{3-[4-(4-methyl-benzoyl)-phenoxy]-3-phenyl...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity towards rat hippocampus GlyT1 transporter expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50126022({[3-(Biphenyl-4-yloxy)-3-(4-fluoro-phenyl)-propyl]...)
Affinity DataKd:  1nMAssay Description:Binding affinity towards rat hippocampus GlyT1 transporter expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50011135(CHEMBL3259928)
Affinity DataEC50:  10nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011136(CHEMBL3259926)
Affinity DataEC50:  24nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011137(CHEMBL3259935)
Affinity DataEC50:  25nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011138(CHEMBL3259930)
Affinity DataEC50:  26nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011139(CHEMBL3259931)
Affinity DataEC50:  28nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011140(CHEMBL3259934)
Affinity DataEC50:  48nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011141(CHEMBL3259937)
Affinity DataEC50:  54nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011142(CHEMBL3259938)
Affinity DataEC50:  60nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011143(CHEMBL3259925)
Affinity DataEC50:  67nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011144(CHEMBL3259936)
Affinity DataEC50:  110nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011145(CHEMBL3259933)
Affinity DataEC50:  170nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011146(CHEMBL3259927)
Affinity DataEC50:  180nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011147(CHEMBL3259939)
Affinity DataEC50:  180nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011149(CHEMBL3259909)
Affinity DataEC50:  230nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011150(CHEMBL3259910)
Affinity DataEC50:  230nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011151(CHEMBL3259932)
Affinity DataEC50:  230nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011152(CHEMBL3259911)
Affinity DataEC50:  270nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011153(CHEMBL3259924)
Affinity DataEC50:  300nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011154(CHEMBL3259923)
Affinity DataEC50:  320nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011155(CHEMBL3259912)
Affinity DataEC50:  380nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011156(CHEMBL3259919)
Affinity DataEC50:  540nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011157(CHEMBL3259908)
Affinity DataEC50:  660nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011158(CHEMBL3259929)
Affinity DataEC50:  670nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011159(CHEMBL3259917)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011160(CHEMBL3259940)
Affinity DataEC50:  1.67E+3nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011161(CHEMBL3259942)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011162(CHEMBL3259918)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Mouse)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50011135(CHEMBL3259928)
Affinity DataEC50:  5nMAssay Description:Inhibition of mouse GlyT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011164(CHEMBL3259913)
Affinity DataEC50:  6.70E+3nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011165(CHEMBL3259922)
Affinity DataEC50:  9.90E+3nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011167(CHEMBL3259914)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011168(CHEMBL3259915)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011169(CHEMBL3259916)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011171(CHEMBL3259920)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011172(CHEMBL3259921)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50011173(CHEMBL3259941)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175925(8-((1S,2S)-2-phenyl-cyclohexyl)-1-(4-trifluorometh...)
Affinity DataEC50:  65nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175911(1-hexyl-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8-tria...)
Affinity DataEC50:  49nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175923(1-(4-methoxy-phenyl)-8-((1S,2S)-2-phenyl-cyclohexy...)
Affinity DataEC50:  66nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175929(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175901(8-((1S,2S)-2-phenyl-cyclohexyl)-1-propyl-1,3,8-tri...)
Affinity DataEC50:  450nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175915(1-cyclohexyl-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8...)
Affinity DataEC50:  750nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175927(1-phenyl-8-((1S,2S)-2-p-tolyl-cyclohexyl)-1,3,8-tr...)
Affinity DataEC50:  85nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175926(1-cyclohexylmethyl-8-((1S,2S)-2-phenyl-cyclohexyl)...)
Affinity DataEC50:  65nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175916(8-[(1S,2S)-2-(4-methoxy-phenyl)-cyclohexyl]-1-phen...)
Affinity DataEC50:  610nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175928(8-((1S,2S)-2-phenyl-cyclohexyl)-1-(2-piperidin-1-y...)
Affinity DataEC50:  7.40E+3nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175910(1-(4-fluoro-phenyl)-8-((1S,2S)-2-phenyl-cyclohexyl...)
Affinity DataEC50:  24nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175907(1-pentyl-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8-tri...)
Affinity DataEC50:  34nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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